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In Europe and Canada

Moclobemide, a reversible MAOI, is available in Europe and Canada. Because it is reversible, moclobemide has little risk of diet or medication interactions. [Pg.245]

Furthermore, health policy makers in Europe and Canada can point to widely respected statistics gathered annually by the Organization for Economic Cooperation and Development, according to which the United States ranks remarkably low in the OECD on many standard health status indicators, such as the infant mortality rate, life expectancy at birth and at age 60, and potential years of life lost per 100,000 population, that is, life... [Pg.39]

Before the disaster in Europe and Canada, thalidomide had been submitted to the FDA for approval in the United States. The FDA did not consider the safety tests of Chemie Griinenthal to be adequate and withheld approval of thalidomide. The United States was therefore spared the thalidomide disaster. Withholding approval for thalidomide is considered to be one of the triumphs of the FDA in protecting public safety.1... [Pg.10]

Topical for HSV. Acyclovir is arailable in Europe and Canada as a 3% ophthalmic ointment but is not commercially manufectured as a topical formulation in the United States. The most common side effects of acyclovir 3% ointment are punctate superficial keratitis, occurring in about 10% of patients, and burning or stinging on application (4%) (Table 11-11 see also Table 11-10). [Pg.201]

Phenelzine (Nardil) and tranylcypromine (Parnate) are the two most common MAOIs. Two newer MAOIs are being studied to evaluate their clinical use both have a reduced risk of hypertensive reaction. Selegiline (Deprenyl) is an MAO-B inhibitor (inhibits type B MAO) that is used in the treatment of Parkinson s disease and may be especially useful for treating depression in patients with Parkinson s. Meclobe-mide, a reversible MAO-A inhibitor, is currently used in Europe and Canada and may soon be available in this country. [Pg.148]

II clinical trials but was withdrawn by NCI because it proved to be too toxic to use as a drug) [68], aplidine (currently under phase II clinical trials in Europe and Canada) [69], and ecteinacidine 743 (passed through phase II clinical trials for treatment of sarcoma, and is enlisted for phase... [Pg.77]

Development is occurring in Europe and Canada as well as the U.S. A recent review article by Page details development of 21 systems, mostly in Canada and West Germany.(8) Several other review articles have recently appeared (9, 10, 11) ... [Pg.8]

Metformin (Glucophage, others) and phenformin were introduced in 1957, and buformin was introduced in 1958. The latter was of limited use, but metformin and phenformin were used widely. Phenformin was withdrawn in many countries during the 1970s because of an association with lactic acidosis. Metformin has been associated only rarely with that complication, and has been used widely in Europe and Canada it became available in the United States in 1995. Metformin given alone or in combination with a sulfonylurea improves glycemic control and lipid concentrations in patients who respond poorly to diet or to a sulfonylurea alone. [Pg.419]

Van Sickle, J., Baker, J.R, Simonin, H.A., Baldigo, B.P., Kretser, W.A. and Sharpe, W.F. (1996). Episodic acidification of small streams in the northeastern United States Fish mortality in field bioassays. Ecological Applications, 6, 408-421. Wright, R.F (2003). Predicting recovery of acidified freshwaters in Europe and Canada. Hydrology Earth System Science, 7, 429—430. [Pg.58]

Maraviroc was granted regulatory approval in the United States and Europe in 2007 as the first prescribed CCR5 antagonist for the treatment of CCR5-tropic confirmed HIV-1 infection in treatment-experienced patients. Maraviroc is sold under the tradename Selzentry (Celsentri in Europe and Canada) [61]. [Pg.215]

Membranes are widely used in Europe and Canada as well as some areas in the United States to limit the ingress of chloride into concrete. They provide good protection as long as the membrane remains leak-free and the riding surface does not deteriorate exposing the membrane. The lifetime of membranes in bridge applications was also addressed by SHRP C 103 [611. [Pg.410]

The cultivation of rape in Europe and Canada became extensive during World War II. In Sweden and in occupied Europe, the loss of the supplies of food oils from tropical and sub-tropical areas led to a greater utilisation of rape for its edible seed oil. In Canada rape was grown to provide the seed oil for use as a special lubricant for the British naval fleet. The success and high yield of these cultivations in cold temperate climates led to the realisation that rape seed could be an important indigenous source of edible oil in Northern countries. Moreover, the seed cake residues, when treated, formed good quality animal food. [Pg.288]

Butyl cyanoacrylate is an intermediate-length CA (Fig. 14.1) adhesive, and was the first product broadly used for closing cutaneous wounds. This compound has been approved for use in Europe and Canada as Histoacryl Blue (trademark of Aesculap, Inc) and GluStitch (trademark of GluStitch Inc.) for nearly 40 years. It was not, however, approved by the US FDA for use in the United States for a long time. In Europe, Canada, and Japan, it has been used for middle ear procedures to close cerebrospinal leaks, to repair incisions and lacerations, and to affix skin since the... [Pg.349]


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See also in sourсe #XX -- [ Pg.503 ]




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