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Chemie Griinenthal

Thalidomide was born out of the Pharmaceutical Industry in the 1950s. At that time the Pharmaceutical Industry comprised a multitude of competing Companies, many of which were not dedicated to drug development, with few or no laws governing development and marketing. Chemie-Griinenthal, who developed thalidomide, was a subsidiary of a soap and cosmetics manufacturer (Dali Werke, Maurer, and Wirtz). Many new medicines were simple concoctions... [Pg.575]

Thalidomide (1.25) was initially released in Germany in 1956 by Chemie Griinenthal (Figure 1.11). The drug had been developed as a sedative and also showed antiemetic... [Pg.9]

Before the disaster in Europe and Canada, thalidomide had been submitted to the FDA for approval in the United States. The FDA did not consider the safety tests of Chemie Griinenthal to be adequate and withheld approval of thalidomide. The United States was therefore spared the thalidomide disaster. Withholding approval for thalidomide is considered to be one of the triumphs of the FDA in protecting public safety.1... [Pg.10]

The U.S.-based pharmaceutical company William S. Merrell, Inc., licensed thalidomide from its German manufacturer, Chemie Griinenthal, in 1958. After carrying out laboratory, animal, and initial human tests, the company submitted an application to the FDA for marketing authorization. Frances Kelsey, the medical officer assigned to review the application, found deficiencies in the animal studies and criticized the company s testing methods.20 She then requested additional toxicity tests, putting the application on hold. [Pg.26]

Chemie Griinenthal GmbH 313 5 9 Chem. Fabr. v. Heyden GmbH 465518 Chem.-Technol. Inst., Dnepropetrovsk 999750 Chen, B.-C. 554 202 Chen, C.-C. 4191671, 6031071 Chen, C.-W. 5028"3 Chen, L.J. 80838 ... [Pg.1075]

Chemical Corp. 434 Chemie Griinenthal GmbH 220 Chemische Werke Albert 424, 553, 556... [Pg.754]

The German chemical company Chemie Griinenthal produced a compoimd that they named thalidomide in the 1950s while tT5dng to find an inexpensive way to prepare an antibiotic from proteins. This compound had no antibiotic activity, but it didn t kill rodents, dogs, or cats when fed to them in large... [Pg.118]

Gestamestrol (Hermal-Chemie)-comb. F (Griinenthal)-comb. Luteran (Solymes) J l.utoral (Shionogi)... [Pg.431]

See other pages where Chemie Griinenthal is mentioned: [Pg.811]    [Pg.811]    [Pg.811]    [Pg.575]    [Pg.577]    [Pg.581]    [Pg.811]    [Pg.811]    [Pg.2006]    [Pg.3343]    [Pg.61]    [Pg.220]    [Pg.1458]    [Pg.5]    [Pg.14]    [Pg.10]    [Pg.811]    [Pg.811]    [Pg.811]    [Pg.575]    [Pg.577]    [Pg.581]    [Pg.811]    [Pg.811]    [Pg.2006]    [Pg.3343]    [Pg.61]    [Pg.220]    [Pg.1458]    [Pg.5]    [Pg.14]    [Pg.10]   
See also in sourсe #XX -- [ Pg.26 , Pg.61 , Pg.62 ]

See also in sourсe #XX -- [ Pg.3 ]



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