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Immunosensors biomarkers

In this section, use of the IO YI as an immunosensor is demonstrated, being relevant, e.g., for identification of biomarkers for early disease detection. The sensor is used to monitor the anti-human serum albumin - human serum albumin (a-HSA-HSA) immunoreaction. [Pg.283]

It is well known that affinity biosensors, usually DNA sensors or immunosensors, require a biorecognition molecule that demonstrates a high affinity and specificity for the target biomarker. [Pg.942]

M.A. Bangar, D.J. Shirale, W. Chen, N.V. Myung, and A. Mulchandani, Single conducting polymer nanowire chemiresistive label-free immunosensor for cancer biomarker. Anal. Chem., 81, 2168-2175 (2009). [Pg.465]

A single Ppy nanowire-based nano immunosensor has been reported with cancer antigen (CA 125) antibody for a CA 125 biomarker detection and quantification. The immunosensor had excellent sensitivity with a lower detection limit of 1 U/mL CA 125 and dynamic range up to 1000 U/ mL in 10 mM phosphate buffer. It has also been shown that there is no loss... [Pg.717]

Qian J, Zhou Z, Cao X, Liu S (2010) Electrochemiluminescence immunosensor for ultrasensitive detection of biomarker using Ru(bpy)3 Lencapsulated silica nanosphere labels. Anal Chim Acta 665(l) 32-38. doi 10.1016/j.aca.2010.03.013... [Pg.142]

Multiplexing has also been achieved with electrochemical immunosensors. Separation of iridium oxide electrodes by 2.5 mm in arrays to eliminate cross-talk enabled simultaneous electrochemical immunoassays using alkaline phosphatase-labeled Ab2 and detection of product hydroquinone giving DLs 1 ng mL for goat IgG, mouse IgG, and cancer biomarkers carcinoembryonic antigen (CEA) and a-fetoprotein (AFP) [35]. An 8-electrode array was developed for detection [36] of... [Pg.4]

We also reported a AuNP immunosensor for detection of IL-6 with a DL of 10 pg mL in calf serum without using labeled magnetic particles [71]. A comparison under the same assay conditions using human IL-6 cancer biomarker in calf semm revealed that the AuNP immunosensor offers a threefold better detection limit than SWCNT forest immunosensors. In another strategy we used 0.5 pm multi-labeled polymeric beads (polybeads-HRP-Ab2) to achieve a DL of 10 pg mL for MMP-3 [72] in calf serum. [Pg.12]

Mani, V., Chikkaveeraiah, B.V., Patel, V., Gutkind, J.S., Rusling, J.F. Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification. ACSNano 3, 585-594 (2009)... [Pg.23]

Rusling, J. F., Sotzing, G., Papadimitrakopoulos, F. Designing nanomaterials-enhanced electrochemical immunosensors for cancer biomarker proteins, Bioelectrochem. 76, 189-194 (2009)... [Pg.24]

Xu, S., Liu, Y., Wang, T., Li, J. Positive potential operation of a eathodie eleetrogenerated chemiluminescence immunosensor based on luminol and graphene fen- eaneer biomarker detection. Anal. Chem 83, 3817-3823 (2011)... [Pg.26]

Sardesai, N.P., Pan, S., Rusting, LF. Eleetrochemiluminescent immunosensor for detection of protein cancer biomarkers using earbon nanotube forests and Ru(bpy)3-doped silica nanoparticles. Chem. Comm. 33, 4968-4970 (2009)... [Pg.26]

Tang, C.K., Vaze, A., Rusling, J.F. Fabrication of immunosensor microwell arrays from gold compact discs for ultrasensitive detection of cancer biomarker proteins. Lab on a Chip (2011, in press). doi 10.1039/ClLC20833K... [Pg.26]

This book provides a comprehensive compilation of seven chapters, with important contributions of several authors. Chapter 1 reviews the recent research in using nanoparticle labels and multiplexed detection in protein immunosensors. This chapter summarizes recent progress in development of ultrasensitive electrochemical devices to measure cancer biomarker proteins, with emphasis on the use of nanoparticles and nanostmctured sensors aimed for use in clinical cancer diagnostics. Based on recent strategies focused on nanomaterials for electrochemical biosensors development. Chap. 2 discusses the development of new... [Pg.141]

M.-I. Mohammed, M.RY. Desmulliez, Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers a review. Lab on a Chip 11 (2011)569-595. [Pg.127]

Wan et al. (2011) describe a CNT-based, multiplexing, electrochemical immunosensor utilizing a sandwich-immunoassay type on a disposable screen-printed carbon electrode for sensitive and simultaneous determination of PSA and interleukin 8 (IL-8), another cancer biomarker. [Pg.196]

Ronkainen, N.J., Okon, S.L., 2014. Nanomaterial-based electrochemical immunosensors for clinically significant biomarkers. Materials 7, 4669 709. [Pg.200]

Wan Y, et al. Carbon nanotube-based ultrasensitive multiplexing electrochemical immunosensor for cancer biomarkers. Biosensors Bioelectronics 2011 30 93-9. http //dx.doi.org/10.1016/j. bios.2011.08.033. [Pg.247]

Yang MH, Javadi A, Li H, Gong SQ. Ultrasensitive immunosensor for the detection of cancer biomarker based on graphene sheet. Biosensors Bioelectronics 2010 26 560-5. http //dx.doi.Org/10.1016/j.bios.2010.07.040. [Pg.247]

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See also in sourсe #XX -- [ Pg.90 , Pg.91 , Pg.92 ]



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