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Matrix-assisted laser desorption/ionization-imaging mass spectrometry

Key words Imaging mass spectrometry, matrix-assisted laser desorption/ionization, MALDI, small... [Pg.173]

A modified version of 2DE and gel image analysis, with silver staining, autoradiography, and protein identification and measurement of peptide mass, uses matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) as a rapid and sensitive technique for identifying peptides. MALDI-TOF-MS applies well to protein detection in biological fluids.56 A second advantage of this technique is... [Pg.87]

Stoeckli, M. Farmer, T. B. Caprioli, R. M. 1999. Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument. J. Am. Soc. Mass Spectrom., 10, 67-71. [Pg.227]

Fig. 33 (a) Mass spectrometry image (m/z = 340) by MALDI and (b) optical image of a letter printed with an ink printer. The size of the images are 1500 x 1500 (rm. (Reprinted by permission of Elsevier Science from Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument , by Stoeckli et al., Journal of the American Society for Mass Spectrometry, Vol. 10, pg 69, 1999, by the American Society for Mass Spectrometry)... [Pg.114]

Sugiura Y, Shimma S, Setou M. Two-step matrix application technique to improve ionization efficiency for matrix-assisted laser desorption/ionization in imaging mass spectrometry. Anal. Chem. 2006 78 8227-8235. [Pg.388]

In a separate study, a protocol for Matrix-assisted laser desorption-ionization (MALDI) imaging mass spectrometry (IMS) has been proposed.18 This IMS technique provides a new approach to visualize spatial distribution of thousands of molecular species, including peptides, proteins, and their metabolites in two- or three-dimensional levels. This approach may also provide a straightforward method of determining the tissue distribution of multiple peptides or proteins in a quantitative manner.18 Chu et al.19 reported a nondestructive molecular extraction method to obtain proteins from a single FFPE or frozen tissue section, without destroying the tissue morphology, such... [Pg.394]

Cheng, Z., Winant, R. C., and Gambhir, S. S. (2005). A new strategy to screen molecular imaging probe uptake in cell culture without radiolabeling using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Nucl. Med. 46 878-886. [Pg.379]

Crossman, L., McHugh, N. A., Hsieh, Y., Korfmacher, W. A., and Chen, J. (2006). Investigation of the profiling depth in matrix-assisted laser desorption/ionization imaging mass spectrometry. Rapid. Commun. Mass. Spectrom. 20 284-290. [Pg.379]

Hsieh, Y., Casale, R., Fukuda, E., Chen, J., Knemeyer, I., Wingate, J., Morrison, R., and Korfmacher, W. (2006a). Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue. Rapid Commun. Mass Spectrom. 20 965-972. [Pg.380]

Todd, P. J., Schaaff, T. G., Chaurand, P., and Caprioli, R. M. (2001). Organic ion imaging of biological tissue with secondary ion mass spectrometry and matrix-assisted laser desorption/ionization. J. Mass Spectrom. 36 355-369. [Pg.382]

Use of Matrix Assisted Laser Desorption/ Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs... [Pg.399]

Matrix assisted laser desorption/ionization imaging mass spectrometry... [Pg.400]

Use of Matrix Assisted Laser Desorption/Ionization Imaging Mass Spectrometry... [Pg.401]

Burrell M, Earnshaw C, Clench M (2007) Imaging matrix assisted laser desorption ionization mass spectrometry a technique to map plant metabolites within tissue at high spatial resolution. J Exp Bot 58(4) 757-763. doi 10.1093/jxb/erll39... [Pg.418]

Trim P, Henson C, Avery J, McEwen A, Snel M, Claude E, Marshall P, West A, Princivalle A, Clench M (2008) Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Anal Chem 80 8628-8634. doi 10.1021/ac8015467... [Pg.420]

Drexler D, Garrett T, Cantone J, Diters R, Mitroka J, Conaway M, Adams S, Yost R, Sanders M (2007) Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissue. J Pharmacol Toxicol Methods 55 279-288. doi 10.1016/j. vascn.2006.11.004... [Pg.420]

Bouslimani A, Bee N, Glueckmann M, Hirtz C, Larroque C (2010) Matrix-assisted laser desorption/ionization imaging mass spectrometry of oxaliplatin derivatives in heated intraoperative chemotherapy (HIPEC)-like treated rat kidney. Rapid Commun Mass Spectrom 24 415-421. doi 10.1002/rcm.4408... [Pg.422]


See other pages where Matrix-assisted laser desorption/ionization-imaging mass spectrometry is mentioned: [Pg.329]    [Pg.336]    [Pg.370]    [Pg.99]    [Pg.362]    [Pg.334]    [Pg.356]    [Pg.360]    [Pg.117]    [Pg.171]    [Pg.202]    [Pg.399]    [Pg.408]    [Pg.418]   


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Assisted Laser Desorption

Desorption ionization

Desorption mass spectrometry

Imaging mass spectrometry

Laser assisted

Laser desorption

Laser desorption ionization mass

Laser desorption ionization mass spectrometry

Laser desorption mass

Laser imaging

Laser ionization

Laser ionization mass spectrometry

Laser ionizing

Laser mass spectrometry

Laser spectrometry

Laser-desorption mass spectrometry

Mass laser ionization

Mass matrix

Mass spectrometry ionization

Mass spectrometry ionized

Mass spectrometry matrix-assisted laser desorption

Mass spectrometry matrix-assisted laser desorption ionization

Matrix assisted

Matrix assisted desorption+ionization

Matrix assisted laser desorption/ionization spectrometry

Matrix assisted laser ionization

Matrix assisted mass spectrometry

Matrix ionization

Matrix spectrometry

Matrix-assisted laser

Matrix-assisted laser desorption imaging mass spectrometry

Matrix-assisted laser desorption ionization

Matrix-assisted laser desorption ionization mass

Matrix-assisted laser desorption mass

Matrix-assisted laser desorption spectrometry

Matrix-assisted laser desorption/ionization-imaging mass

Matrix-assisted laser imaging

Matrix-assisted laser spectrometry

Matrix-assisted laser-desorption

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