Hypolipidaemics

Male Fischer 344 rats (body weight, 100-150 g) were fed 0.5-4% di(2-ethyl-hexyl) phthalate in the diet for one or four weeks and male Swiss Webster mice (20-30 g) were fed 2 or 4% di(2-ethylhexyl) phthalate in the diet for one or four weeks (Reddy etal., 1976). Di(2-ethylhexyl) phthalate increased relative liver weights and markedly induced hepatic carnitine acetyltransferase activity in both species (up to 25-fold in rats and 10-fold in mice). Some increase in hepatic catalase activity (approximately two-fold) was observed and subjective (non-morphometric) ultra-structural examination revealed marked peroxisome proliferation. This study also demonstrated that di(2-ethylhexyl) phthalate was a hypolipidaemic agent, as serum triglyceride levels were reduced to one seventh of control values in rats and one third of control values in mice. 

Ficus carica L. Wu Hua Go (Fig) (leaf, fruit) Bergaptin, cerotinic acid, ficusin, glutamine, papain, pepsin, psoralen, guaiaxulene, amyrin, lupeol, retin, octacosane, guaiacol, quercitin, rhamnose, sitosterol, tyrosine, urease.50 55,502 For stomachache, externally for swollen piles, corns, warts. Fruit is laxative, digestive, anthelmintic, hypolipidaemic, and hypotriglyceridaemic acitivities... 

Bruckert E, Giral P, Heshmati HM, Turpin G. Men treated with hypolipidaemic drugs complain more frequently of erectile dysfunction. J Clin Pharm Ther 1996 21(2) 89-94. 

Issemann I, Prince RA, Tugwood JD, et al. 1993. The peroxisome proliferator-activated receptor retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. J Mol Endocrinol 1137-47. 

Price SC, Chescoe D, Grasso P, et al. 1988a. Alterations in the thyroids of rats treated for long periods with di-(2-cthylhexyl) phthalate or with hypolipidaemic agents. Toxicol Lett 40 37-46. 

Mathur, R., Sharma, A., Dixit, V.P., and Varma, M. 1996. Hypolipidaemic effect of fruit juice of Emblica officinalis in cholesterol-fed rabbits. J. Ethnopharmacol. 50, 61-68. 

Sharma, R.D. 1996. Hypolipidaemic effect of fenugreek seeds a chronic study in non-insulin dependent diabetic patients. Phytother. Res. 10, 332-334. 

Sharma, S.B. and Dwivedi, S. 1997. Medicinal plants with hypolipidaemic activities. Indian Drugs 34(5), 242-251. 

Dietary curcumin can alleviate dangerous secondary complications induced by diabetes. The beneficial effects of dietary curcumin on diabetic nephropathy are probably mediated through the hypolipidaemic effects of curcumin (Babu and Srinivasan, 1997). 

Curcumin has been proved to be an effective hypolipidaemic agent (Babu and Srinivasan, 1997). One study validated the role of dietary curcumin in maintaining healthy serum cholesterol levels in diabetic rats. Employing a high-cholesterol diet for the diabetic rats, curcumin exhibited a lowering of cholesterol and phospholipid in treated animals as compared with curcumin-free controls. Liver cholesterol, triglycerides and phospholipid elevated under diabetic conditions were lowered by dietary curcumin. Curcumin induces a... 

The leaves are a stimulant and are used in rheumatism and diarrhoea. Its bark is useful for the treatment of gonorrhoea (Kirtikar and Basu, 1984). The essential oil from C. tamala exhibits antifungal, antidermato-phytic, hypoglycaemic and hypolipidaemic effects. 

Sharma, S.R., Dwivedi, S.K. and Swarup, D. (1996) Hypoglycaemic and hypolipidaemic effects of Cinnamomum tamala Nees leaves. Indian Journal of Experimental Biology 34, 372-374. 

The ethanolic extract of nutmeg kernels showed hypolipidaemic effect in albino rabbits. Administration of 500mg/kg of the extract daily for a period of 60 days in the hyperlipidaemic rabbits resulted in significantly lower levels of lipoprotein lipids (total cholesterol 574 61 versus 210 27mg/dl low-density lipoprotein (LDL) cholesterol 493 57 versus 131 25mg/dl and triglycerides 108 14 versus 67 in control versus experimental) (Ram et al., 1996). 

Ram, A., Fauria, P., Gupta, R. and Sharma, V.N. (1 996) Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits. Journal of Ethnopharmacology 55(1), 49-53. 

Apart from its use in cooking and cosmetics, it has a number of documented medicinal uses it has effects on the gastrointestinal system, reproductive system, nervous system and immune system and hypoglycaemic, hypolipidaemic, antimicrobial, antioxidant and chemoprotective activity. 

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