Hydroxypropyl P-cyclodextrin

To circumvent these difficulties, a preparation of water-soluble coelenterazine has been developed (Teranishi and Shimomura, 1997a). The preparation contains coelenterazine and 50-times (by weight) of hydroxypropyl-P-cyclodextrin. To prepare this material, 0.1 ml of 3.0 mM coelenterazine in methanol and 0.2 ml of 45 mM solution of the cyclodextrin are mixed and dried under reduced pressure. The dried residue is extracted with 1.0 ml of lOmM phosphate buffer, pH 7.0, containing 2 mM EDTA (if needed), and the extract (after centrifugation) is again dried under reduced pressure. With this preparation, an aqueous solution containing up to 3 mM coelenterazine can be made. 

Teranishi, K., and Shimomura, O. (1997a). Solubilizing coelenterazine in water with hydroxypropyl-p-cyclodextrin. Biosci. Biotech. Biochem. 61 1219-1220. 

Menges, R.A., Armstrong, D.W. (1991) Use of a three-phase model with hydroxypropyl-p-cyclodextrin for the direct determination of large octanol-water and cyclodextrin-water partition coefficients. Anal. Chim. Acta 255, 157-162. 

Abbreviations. BZC, benzalkonium chloride PS, potassium sorbate CDs, cyclodextrins HP-fS-CD, 2-hydroxypropyl-p-cyclodextrin HPMCAS, hydroxypropyl methylcellulose acetate succinate PEG, polyethylene glycol P-407, poloxamer 407 PVAP, poly vinylacetate phthalate. 

Jambhekar, S., Casella, R., and Maher, T. 2004. The physicochemical characteristics and bioavailability of indomethacin fromp-cyclodextrin, hydroxyethyl-fs-cyclodextrin, and hydroxypropyl-p-cyclodextrin complexeslnt. J. Pharm.270 149-166. 

Ko, S.-O., Schlautman, M.A., and Carraway, E.R. (1999). Partitioning of hydrophobic organic compounds to hydroxypropyl--P-cyclodextrin Experimental studies and model predictions for surfactant-enhanced remediation applications. Environ. Sci. Technol., 33, 2765-2770. 

Adsorption chromatography on cellulose was examined for azo dyes that form complexes with CDs using aqueous solutions of a-CD as eluents. The cyclodextrin substantially increases the RF values [61], Commercial a-, [>-. and y-CD polymers were used for the same purpose, however changes of RF were observed only for some azo dyes [62], 2-Hydroxypropyl-P-cyclodextrin used in 10-20% concentration causes complete elution of many compounds [63],... 

McCormack, B., and Gregoriadis, G. (1996), Comparative studies of the fate of free and liposome-entrapped hydroxypropyl-P-cyclodextrin-drug complexes after intravenous injection into rats Implications in drug delivery, Biochim. Biophys. Acta, 1291, 237-244. 

Nijhawan, R., and Agarwal, S. P. (2003), Development of an ophthalmic formulation containing ciprofloxacin-hydroxypropyl-P-cyclodextrin complex, Boll. Chim. Farm,., 142(5), 214-219. 

Muller, B. W., and Brauns, U. (1986), Hydroxypropyl-P-cyclodextrin derivatives Influence of average degree of substitution on complexing ability and surface activity, J. Pharm. Set, 75, 571-572. 

Muller, B. W. (2000), Hydroxypropyl P-cyclodextrin in drug formulation, paper presented at the CRS Workshop What s New in Cyclodextrin Delivery Paris, July 7-8, Article 3. 

An aqueous solution of 17.68 ml of water and hydroxypropylated p-cyclodextrin (1.6 mmol) was treated with 1,1-diphenylethylene (1.6 mmol). This solution was then treated with 150 g of water and 2-hydroxyethyl methacrylate (538 mmol), heated to 85°C, and further treated with the dropwise addition of ammonium peroxodisulfate (4.8 mmol) dissolved in 10 g of water. The solution temperature was next raised to 90°C, and the mixture was reacted for 5 hours. A clear orange solid was obtained having a of 5200 dal tons with a polydispersity of 1.21. 

A study related to the buccal bioavailability of testosterone indicated the absorption enhancing effect of hydroxypropyl-p-cyclodextrine with a relative bioavailability of 165% versus the administration without absorption enhancers. This effect was probably due to an increased solubility of testosterone, although cyclodextrins might also extract lipids from the intercellular matrix.f In the same study, sodium tauro-24,25-dihydrofusidate and sodium deoxycholate did not show any enhancing properties. 

Nagarsenker, M.S. Tantry, IS. Shenai, H. Influence of hydroxypropyl-P-cyclodextrin on the dissolution of keto-profen and irritation to gastric mucosa after oral administration in rats. Pharm. Sci. 1997, 3 (9), 443-445. 

Doenicke, A. Roizen, M.F. Nebauer, A.E. Kugler, A. Hoernecke, R. Beger-Hintzen, H. A comparison of two formulations for etomidate, 2-hydroxypropyl-P-cyclodextrin (HPCyclodextrin) and propylene glycol. Anesth. Analg. (NY) 1994, 79 (5), 933-939. 

Mielcarek, J. Photochemical stability of the inclusion complexes of nicardipine with a-, y-cyclodextrin, methyl-P-cyclodextrin, and hydroxypropyl-P-cyclodextrin in the solid state and in solution. Pharmazie 1996, 51 (7), 477-479. 

Szathmary, S.C. Seiler, K.U. Luhmann, I. Huss, H.J. Pharmacokinetic behavior and absolute bioavailabihty of hydroxypropyl P-cyclodextrin after increasing doses in volunteers. Minutes of the 5th International Symposium Cyclodextrin Duchene, D., Ed. Editions de Sante Paris, 1990, 535-540. 

Gerloczy, A. Antal, S. Szatmari, I. Muller-Horvath, R. Szejtli, J. Absorption, distribution and excretion of carbon-14 labeled hydroxypropyl P-cyclodextrin in rats following oral administration. Minutes 5th International Symposium on Cyelodextrins. Duchene, D., Ed. Editions de Sante Paris, 1990 507-513. 

Mesens, J.L. Putteman, P. Verheyen, P. Pharmaceutical appheations of 2-hydroxypropyl P-cyclodextrin. In New Trends in Cyelodextrins and Derivatives Duchene, D., Ed Editions de Sante Paris, 1991 369 07. 

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