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Cyclodextrins delivery

Muller, B. W. (2000), Hydroxypropyl P-cyclodextrin in drug formulation, paper presented at the CRS Workshop What s New in Cyclodextrin Delivery Paris, July 7-8, Article 3. [Pg.1243]

Spin trapping methods were also used to show that when carotenoid-P-cyclodextrin 1 1 inclusion complex is formed (Polyakov et al. 2004), cyclodextrin does not prevent the reaction of carotenoids with Fe3+ ions but does reduce their scavenging rate toward OOH radicals. This implies that different sites of the carotenoid interact with free radicals and the Fe3+ ions. Presumably, the OOH radical attacks only the cyclohexene ring of the carotenoid. This indicates that the torus-shaped cyclodextrins, Scheme 9.6, protects the incorporated carotenoids from reactive oxygen species. Since cyclodextrins are widely used as carriers and stabilizers of dietary carotenoids, this demonstrates a mechanism for their safe delivery to the cell membrane before reaction with oxygen species occurs. [Pg.167]

Bellocq NC, Pun SH, Jensen GS, Davis ME (2003) Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery. Bioconjug Chem 14 1122-1132... [Pg.23]

Pun SH, Tack F, Bellocq NC, Cheng J, Grubbs BH, Jensen GS, Davis ME, Brewster M, Janicot M, Janssens B, Floren W, Bakker A (2004) Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles. Cancer Biol Ther 3 641-650... [Pg.24]

Davis ME (2009) The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle from concept to clinic. Mol Pharmaceutics 6 659-668... [Pg.30]

Encapsulation within an enteric coat (resistant to low pH values) protects the product during stomach transit. Microcapsules/spheres utilized have been made from various polymeric substances, including cellulose, polyvinyl alcohol, polymethylacrylates and polystyrene. Delivery systems based upon the use of liposomes and cyclodextrin-protective coats have also been developed. Included in some such systems also are protease inhibitors, such as aprotinin and ovomucoids. Permeation enhancers employed are usually detergent-based substances, which can enhance absorption through the gastrointestinal lining. [Pg.71]

K. Abe, T. Irie, and K. Uekama. Enhanced nasal delivery of luteinizing hormone releasing hormone agonist buserelin by oleic acid solubilized and stabilized in hydroxypropyl-/S-cyclodextrin. Chem Pharm Bull 43 2232-2237 (1995). [Pg.231]

Minami, K., Hirayama, F., and Uekama, K., Colon-specific drug delivery based on a cyclodextrin prodrug release behavior of biphenylylacetic acid from its cyclodextrin conjugates in rat intestinal tracts after oral administration, J. Pharm. Sci., 87 715-720 (1998). [Pg.58]

Hwang, S., Bellocq, N., Davis, M.E. (2001). Effects of structure of -cyclodextrin-containing polymers on gene delivery. Bioconjugate Chem., 12, 280-290. [Pg.370]

Challa, R., A. Ahuja, J. Ali, and R. Khar (2005). Cyclodextrins in drug delivery an updated reAi RS Pharm. Sci. Tech., 6 E329-E357. [Pg.130]

Loftsson, T., Leeves, N., Sigurjonsdottir, J. F., Sigurosson, H. H., and Masson, M. 2001. Sustained drug delivery system based on a cationic polymer and an anionic drug/cyclodextrin corfiftemazie. [Pg.157]

Loftsson, T. and Masson, M. 2004. The effects of water-soluble polymers on cyclodextrins and cyclodextrin solubilization of drugsJ. Drug Delivery Sci. Technol. 14 35-43. [Pg.157]

Marttin, E., Verhoef, J. C., and Merkus, F. W. H. M. 1998. Ef cacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein dtdgsug Target. 6 17-36. [Pg.157]

Zou, M. J., G. Cheng, H. Okamoto, X. H. Hao, F. An, F. D. Cui, and K. Danjo. 2005. Colon- spateug delivery systems based on cyclodextrin prodriigsritro evaluation of 5-aminosalicylic acid from its cyclodextrin conjugateSAforld J. Gastroenterol. 11 7457-7460. [Pg.466]

Matsuda, H., and Arima, H. 1999. Cyclodextrins in transdermal and rectal delivery. Adv Drug Deliv Rev 36 81. [Pg.146]

Inhibitory Effects of Cyclodextrins of Drug Irritancy in Rectal Delivery.157... [Pg.147]

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See also in sourсe #XX -- [ Pg.157 ]



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