Cyclodextrins drug complexes

McCormack, B., and Gregoriadis, G. (1996), Comparative studies of the fate of free and liposome-entrapped hydroxypropyl-P-cyclodextrin-drug complexes after intravenous injection into rats Implications in drug delivery, Biochim. Biophys. Acta, 1291, 237-244. 

Even though cyclodextrins drug complexes seem to decrease ocular toxicity of irritant drugs, cyclodextrins themselves may exhibit ocular toxicity and should therefore be screened by performing corneal sensitivity studies. Among all cyclodextrin derivates investigated, hydroxy-propyl-P-cyclodextrin showed the most favorable properties in terms of toxicity [1],... 

Several studies have shown that combinations of cyclodextrins drug complexes and viscosity enhancers can significantly improved ocular absorption [141,236-237] and should therefore be further investigated. 

Faucci, M. T. and P. Mura (2001). Effect of water-soluble polymers on naproxen complexation with natural and chemically modi e0-cyclodextrins.Drug Dev. Ind. Pharm., 27 909-917. 

W. R. Anderson, J. W. Simpkins, M. E. Brewster, and N. Bodor, Brain-enhanced delivery of testosterone using a chemical delivery system complexed with 2-hydroxy-propyl-P-cyclodextrin, Drug Des. Del. 2 287 (1988). 

Mielcarek J. Analytical study of photodegradation of inclusion complexes of nimodip-ine with a, g-cyclodextrin, methyl-b-cyclodextrin and hydroxypropyl-b-cyclodextrin. Drug Dev Ind Pharm 1998 24(2) 197-200. 

Pedersen, M. Effect of hydrotropic substances on the complexation of clotrimazole with P-cyclodextrin. Drug Dev. Ind. Pharm. 1993,19 (4), 439 8. 

Alprostadil (Edex , Schwartz) is a lyophilized product of Prostaglandin Ei in a-cyclodextrin inclusion complex. The complex has better stability and aqueous solubility than the drug itself... 

Lin, S. Kao, Y. Solid particulates of drug-Jl-cyclodextrin inclusion complexes directly prepared by a spray-drying technique. Int. J. Pharm. 1989, 56, 249-259. 

Keywords Biomaterials, Cyclodextrin, Drug delivery, Hydrogel, Inclusion complex, Polyrotaxane, Supramolecule... 

Development of parenteral formulations of all-fram-retinoic acid is possible by using 2-hydroxypropyl-P-cyclodextrin, and inclusion into the carrier also leads to an improved photostability of the drug (Lin et al 2000). Aqueous cyclodextrin solutions are shown to extract plastic additives when stored in containers of polypropylene (Peiris et al., 1999 see Section 14.3). The result may be photosensitized decomposition of the drug. Photochemical stability of drug-cyclodextrin inclusion complexes are further discussed in Chapter 16. 

Eto, S. Noda, H. Noda, A. Simultaneous determination of antiepileptic drugs and their metabolites, including chiral compounds, via 3-cyclodextrin inclusion complexes by a column-switching chromatographic technique. J.Chromatogr.B, 1994, 658, 385-390... 

Menard FA, Dedhiya MG, Rhodes CT, Physico-chemical aspects of the complexation of some drugs with cyclodextrins. Drug Develop. Indust. Pharm. 1990 16 91-113. 

Microcapsules of synthetic polymer and cyclodextrin Three examples in the literature mention an association between synthetic polymer microcapsules and CyDs [12-14] as a means of encapsulating drugs complexed with CyDs. 

Armstrong, D.W. Ward, T.J. Armstrong, R.D. Beesley, T.E. Separation of drug stereoisomers by the formation of beta-cyclodextrin inclusion complexes. Science 1986, 232, 1132. 

D.W. Armstrong, T.J. Ward, R.D. Armstrong and T.E Beesley, Separation of Drug Stereoisomers by the Formation of P-Cyclodextrin Inclusion Complexes, Science, 232(1986)1132. 

This field is very broad because a vast number of drugs can be complexed. Nevertheless also this field has its definite limits, over which only a negligible rate of succes on account of technical, or economical reasons can be expected. The knowledge accumulated so far on this field allows us to delineate the sensible limits of cyclodextrin applications in drug complexation. Taking these... 

As table III.shows the application of cyclodextrin inclusion complexes instead of free drugs results in a remarkably enhanced absorption of lipophylic drugs even from fatty suppository bases /e.g. Adeps solidus, Butyrimi caco/ ... 

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