1- Hydroxy-7-methoxy-2-nitro

Cassimjee et al. reported [22] that a variant engineered aminotransferase at TrpOOCys from Chromohacterium violaceum showed a 29-fold increase on spedfidty for synthesis of (S)-phenylethylamine and about fivefold on spedfidty for 4 -substituted acetophenones, where the groups at 4 position were bromo, chloro, hydroxy, methoxy, nitro, methyl, and cyano. The amine donor was isopropylamine. The reaction schemes are shown in Figure 7.5. 

A series of 11 nitrobenzaldehydes was examined by TGA, DSC and ARC techniques. Only 5-hydroxy-2-nitrobenzaldehyde decomposed exothermally in an unsealed container, but all did so in sealed capsules, under dynamic, isothermal or adiabatic conditions, with evolution of much gas. Initial decomposition temperatures in °C (compound, ARC value, and DSC value at lOVmin, respectively, followed by ARC energy of decomposition in kJ/g) were - 2-nitro-, 176, 220, 1.44 3-nitro-, 166, 218, 1.94 4-nitro-, 226, 260, 1.27 2-chloro-5-nitro-, 156, 226, 697 2-chloro-6-nitro-, 146, 220,. 832 4-chloro-3-nitro-, 116, 165, 1.42 5-chloro-2-nitro-, 240, 3-hydroxy-4-nitro-, 200, 4-hydroxy-3-nitro-, 200, 5-hydroxy-2-nitro-, 175, 3-methoxy-4-nitrobenzaldehyde, 245°C, -. 4-Nitrobenzaldehyde showed by... 

Diese Methode eignet sich auch fiir die Mononitrierung von 4-Methyl- bzw. 4-Chlor-phenol. Aus 4-Methoxy-phenol erhalt man ausschlieBlich 2,6-Dinitro-phenol. Die Nitrierung von 2-Hydroxy-naphthalin liefert 2-Hydroxy- 1-nitro-naphthalin bzw. 2,6-Dinitro-2-hydroxy-naphthalin in 68 bzw. 32%iger Ausbeute. Die Nitrierung von Hetarenen wie Pyrrol oder Indol fuhrt dagegen selbst bei — 78° zu teerartigen Produkten. 

Hydroxy-1,5-naphthyridin-2( I //i-one 5-oxide 4-Hydroxy-3-nitro-l,5-naphthyridin-2(17/)-one 2-Iodo-1,5-naphthyridine 4-Iodo-1,5-naphthyridine 4-Isopropylamino- 1,5-naphthyridine 1-oxide 2-Isopropyl-6-methoxy-1,5-naphthyridine-... 

Hydroxy-2-nitro- -ethylester E19d, 618 [Nitronat + OC(OR)2] 3-Methoxy-2-nitro- -methylester X/l, 173... 

The second-order rate constants for the reaction of OH radical with meta- and para-isomers of hydroxy-, methoxy-, chloro- and nitro-benzaldehydes are in the range (2.8 to 12) x 10 dm mol s . The higher rate in methoxybenzaldehyde is attributed to the activation of the ring by the electron-donating -OCH3 group. 

Bei der Umlagerung von Formylimino-benzofuroxanen werden 2-Hydroxy-7-nitro-2H-in-dazole erhalten (vgl. S. 804), die substituenten- und losungsmittelabhangige UV-Spektren zei-gen in Wasser erfolgt demnach beim 6-Methoxy-Derivat eine tautomere Verschiebung von der 2-Hydroxy-Form zum 2-Oxid, dem 6-Methoxy-7-nitro-lH-indazol-2-oxid139. Beim 6-C-hlor-Derivat ist dieser Effekt nicht sichtbar. 

Based on the U.S. International Trade Commission Import (39) data, nearly 3.7 million worth of Naphthol AS and derivatives (5511) were imported in 1983. Commercially important coupling components include Azoic Coupling Component 2 (3-hydroxy-2-naphthanilide [92-77-3]) (85) Azoic Coupling Component 17, Naphthol AS-BS, (3-hydroxy-3-nitro-2-naphtha.nilide) (86) Azoic Coupling Component 18, Naphthol AS-D, (3-hydroxy-2-methyl-2-naphthanilide) (87) and Azoic Coupling Component 20, Naphthol AS-OL, (3-hydro xy-2 -methoxy-2-naphthanilide) (88) (Table 9). 

Hydroxide ion replaces the methoxide of 7-methoxy-4-nitrobenzofuroxan to form the 7-hydroxy-4-nitro compound, which rearranges to the 5-hydroxy-4-nitro derivative, under certain conditions.418 Buncel et al.501 have also described the demethylation of 7-methoxy-4,6-dinitrobenzofuroxan by methoxide ion. 

The methyl, hydroxy, methoxy, chloro, cyano, and nitro derivatives of A -methyl-A -nitrosoaniline were separated on a Cjg column (A = 290 nm) using a 30/70 acetonitrile/water (lOmM phosphate buffer at pH 5.6) mobile phase [948]. The methyl and chloro derivative peaks were noticably fronted. Elution was complete in 30 min. The same separation was achieved in <15 min with excellent peak shapes, when the mobile phase was changed to acetonitrile/methanol/water/80% H3PO4 (at pH 3.2). A mobile phase pH low enough to keep the amine analytes fully protonated seems to be necessary to prevoit unfavorable analyte interaction with the silica support. Plots of log k versus percent acetonitrile (from 20% to 50%) were nonlinear. The detection limits were reported as 3 x 10 M. Linear ranges were found to cover the range 5 x 10" to 2 x lO"" M. 

When large groups, such as phenyl, bromo, ethoxycarbonyl or nitro are attached at position 3, the principal products are l-alkylcinnolin-4(l/f)-ones. Cyanoethylation and acetylation of cinnolin-4(l/f)-one takes place exclusively at N-1. Phthalazin-l(2/f)-ones give 2-substituted derivatives on alkylation and acylation. Alkylation of 4-hydroxyphthala2in-l(2/f)-one with an equimolar amount of primary halide in the presence of a base leads to 2-alkyl-4-hydroxyphthalazin-l(2/f)-one and further alkylation results in the formation of 4-alkoxy-2-alkylphthalazinone. Methylation of 4-hydroxy-2-methyl-phthalazinone with dimethyl sulfate in aqueous alkali gives a mixture of 4-methoxy-2-methylphthalazin-l(2/f)-one and 2,3-dimethylphthalazine-l,4(2//,3//)-dione, whereas methylation of 4-methoxyphthalazin-l(2/f)-one under similar conditions affords only 4-methoxy-2-methylphthalazinone. 

Imidazole, 1 -hydroxy-2,4,5-triphenyl-3-oxides reactions, S, 455 Imidazole, iodo-nitrodehalogenation, 5, 396-397 Imidazole, 1-iodo-reactions, S, 454 stability, S, 110 Imidazole, 2-iodo-synthesis, S, 401 Imidazole, N-iodo-, S, 393 reactions, 5, 454 Imidazole, 4-iodo-5-methyl-iodination, 5, 400 Imidazole, 2-isopropyl-4-nitro-N-nitration, 5, 351 Imidazole, 2-lithio-reactions, S, 106, 448 Imidazole, 2-mercapto-l-methyl-as antithyroid drug, 1, 171 mass spectra, 5, 358 Imidazole, 1-methoxymethyl-acylation, S, 402 Imidazole, 5-methoxy-l-methyl-reactions... 

R = Ar) and cyclized tricyclic compound 240 (R = Ar) was obtained when 2-bromoacetophenones were reacted with 8-hydroxyquinolin-2(l//)-one under the above conditions. Presence of a 4-methoxy substituent shifted the equilibrium to the ring-opened product 241 (R = 4-MeOPh), while that of 4-nitro group gave only cyclized product 240 (R = N02). Similarly, mixtures of ring-opened and 2,3,6,7-tetrahydro-5//-pyrido[l,2,3- /e]-l,4-benzoxazin-5-one derivatives were formed in the reaction of 8-hydroxy-l,2,3,4-tetrahydroquinolin-2-one and halomethyl ketones (00HCA349). 

Nitro-2-hydroxy-5-methyl- 693 2 -Nitro-4-methoxy- 693 2 -Nitro-4-methyl- 693... 

Methyl-phenyIthio)-(4-nitro-phenyl)- 700 (2-Nitro-phcnyl)-(2-hydroxy-5-methyl-phenyl)- 693 (2-Nitro-phenyl)-(4-methoxy-phenyl)- 693 (2-Nitro-phenyl)-(4-methyl-phenyl)- 693 Phenyl-(4-amino-phenyl)- 568 Ph en yl-(4-formyl-phenyl) -... 

AthyI-(4-amino-phcnyl)- 684 Athyl-benzyl- 500 Bis-[4-brom-phenyI]- 572 Bis-[4-chlor-phenyl]- 488 Bis-[4-hydroxy-phenyl]- 572 Bis-14-methoxy-phenyl]- 572 Bis-[4-methyl-phenyl]- 572 Bis-[4-nitro-phenyl]- 572 a-Brom- 534f. 

Acetyl-phenyl- 635 4-Amino-3,5-dimethyl-phenyl- 102 2-Amino-4-hydroxy-phenyl- 692 4-Amino-phenyl- 685 4-Benzylamino-phenyl- 102 2,4-Dinitro-phenyl- 692 4-(2-Hydroxy-benzylamino)-phenyl- 102 2-(2-Methyl-butanoyl)-phenyl- 635 4-Methoxy-2,6-dimethyl-phenyl-102 (Nitro-phenyl)- 635 2-Nitro-phenyl- 680, 692 4-Nitro-phenyl- 685... 

Bis-[4-hydroxy-benzoyl]- 658 2,2 -Bis-[4-methoxy-benzoyl]- 658, 678 2,2 -Bis-[4-methyl-benzoyl]- 678 2,2 -Bis-[3-nitro-benzoylJ- 678 Brom- 678 4-Brom- 406... 

Dimethylamino-methyl)-2-hydroxymethyl-aus 2 -Carboxy-2-(dimethylaminocarbonyl)-biphenyl und Lithiumalanat 165 2,2 -Dinitro- 474, 476, 695 6,6 -Dinitro-2,2 -bis-[chlorcarbonyl]- 188 2,2 -Dinitro-4,4 -bis-[diathylamino]- 695 4,4 -Dinitro-2,2 -bis-rhydroxymethyl]- 213 6,6 -Dinitro-2,2 -bis-[hydroxymethyl]- 188 2,2 -Dinitro-4,4 -diamino- 695 6,6 -Dinitro-2,2 -diformyl- 694 4,4 -Dinitro-2,2 -dimethoxycarbonyl- 213 2,2 -Dinitro-4,4 -dimethyl- 695 6,6 -Dinitro-2 -formyl-2-carboxy- 694 2,2 -Dinitroso- 476 -4-hydroxamsaure-chlorid 537 4-(a-Hydroxy-benzyl)- 542 Methoxy- 678 2-Methyl- 556 Nitro- 672, 678 4-Nitro- 687... 

Chorionic gonadotropin. Follicle stimulating hormone Urea, Uric add. Bilirubin, Cortisol, n-Maimitol. n-Glucose, Sodium pyruvate, 4-hydroxy-3-methoxy mandelic add, 4-Nitro-phenol, 17 Amino adds in HQ, Angiotensin-I, Tripahnitin, Bone meal (8 elements), Bone ash (8 elements), lithium carbonate Luteinizing hormone. Thyroid stimulating hormone... 

In the preparation of iodides, but not bromides, PMHS may be substituted for the TMDO. Chlorides can be obtained if thionyl chloride and zinc iodide are added to suppress the formation of symmetrical ethers.314 An example of this type of reductive chlorination is shown by the TMDO-mediated conversion of p-tolualdehyde into p-methylbenzyl chloride (Eq. 201).313 To obtain chlorides from aldehydes having electron-withdrawing groups such as nitro or carbomethoxy, the initial reaction is first carried out at —70° and the mixture is then heated to reflux in order to reduce the formation of symmetrical ether by-products. Zinc chloride is substituted for zinc iodide for the synthesis of chlorides of substrates with electron-donating groups such as methoxy and hydroxy.314... 

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