2-Dimethylamino-6-methyl

Formations of 6-dimethylamino-2,4-hexadiene (163) from 1,6-dimethyl-3-piperideine,87 5-dimethylamino-4-methyl-1,3-pen tadiene (164) from l,3-dimethyl-3-piperideine,82 5-dimethylamino-3-methyl-1,3-pentadiene (165) from l,4-dimethyl-3-piperideine,83 and 6-di-methylamino-2,4-heptadiene (166) from l,2,6-trimethyl-3-piperi-deine94 may serve as further examples of the Hofmann exhaustive methylation in the 3-piperideine series. 

Isoquinoline, l-(dimethylamino)-methylation, 2, 179 Isoquinoline, halo-lithium derivatives, 2, 363 Isoquinoline, 3-halo-nucleophilic substitution, 2, 59 Isoquinoline, l-halo-3-hydroxy-synthesis... 

Reaction of 2-amino-4/f-pyrido[l,2-n]pyrimidin-4-ones 143 with HNMei -HCl and paraformaldehyde in Dowtherm A afforded a mixture of 3-(A,A-dimethylamino)methyl derivatives 144 and bis-compounds 145 (93FES1225). Mannich reaction of 9-hydroxy-2-methyl-4//-pyri-dor],2-nlpyrimidin-4-one (146) yielded 8-aminomethyl derivatives 147 (94KFZ(10)23). 

Chemical Name N-[2-[ [ [5-(Dimethylamino)methyl-2-furanyl] methyl] thiol ethyl] -N -methyl-2-nitro-l, 1 -ethenedlamlne... 

Dimethylamino)methyl-2-furanyl] methyl] thio] ethanamine Manufacturing Process... 

The solution was then heated at reflux for A hour, cooled to 70°C and 4-methylpentan-2-one (2 liters) added. The water was removed by azeotropic distillation under reduced pressure (260 torrs) and the resultant solution treated with charcoal (10 g) at 50°C. The solution was filtered and cooled to 10°C. N-[2-[ [ [5-dimethylamino)methyl-2-furanyl] methyl] thio] ethyl] -N -methyl-2-nitro-1,1 -ethenediamine (380 g) was filtered off and dried, melting point 69°C to 70°C. 

Benzyloxy-2-dimethylamino methyl indole Mepindolol 2-Benzyloxyethanol Flupentixol... 

Chloro-7-(2-fluorophenyl)-5/f-dibenz[c,e]azepine (54) has been prepared in a similar manner from 2-[2-(bromomethyl)phenyl)-5-chloro-2 -fluorodiphenyl ketone (53, X = Br),93 but can be obtained in a superior yield (85%) as the methanesulfonate salt by cleavage of the [(dimethylamino)methyl] derivative 53 (X = NMe2) with cyanogen bromide followed by treatment with ethanolic ammonia.94... 

As is the case for 2 + 2 strategies for porphyrin syntheses, the 3 + 1 approach can also be carried out at a lower oxidation level using 2,5-bis[(dimethylamino)methyl]pyrroles 4 instead of pyrroledicarbaldehydes.50... 

Dihydroxy-1,4-bis- [dim ethyl-amino-meihyl]-benzol6 3-Hydroxy-2-dimethylamino-methyl-naphlhalin6... 

Dimcthyl-5-(dimethylamino-methyl)- 303 5-Diphenylmethylen- 63 5-(a-Hydroxy-benzyliden)-l-benzoyl- 63... 

Amino-l-(dimethylamino-methyl)- 475 2-Amino-l-diphenylamino- 685 2-Amino-l-methoxy- 536 4-Amino-l-methoxy- 477... 

Dimethylamino-methyl)-2-hydroxymethyl-aus 2 -Carboxy-2-(dimethylaminocarbonyl)-biphenyl und Lithiumalanat 165 2,2 -Dinitro- 474, 476, 695 6,6 -Dinitro-2,2 -bis-[chlorcarbonyl]- 188 2,2 -Dinitro-4,4 -bis-[diathylamino]- 695 4,4 -Dinitro-2,2 -bis-rhydroxymethyl]- 213 6,6 -Dinitro-2,2 -bis-[hydroxymethyl]- 188 2,2 -Dinitro-4,4 -diamino- 695 6,6 -Dinitro-2,2 -diformyl- 694 4,4 -Dinitro-2,2 -dimethoxycarbonyl- 213 2,2 -Dinitro-4,4 -dimethyl- 695 6,6 -Dinitro-2 -formyl-2-carboxy- 694 2,2 -Dinitroso- 476 -4-hydroxamsaure-chlorid 537 4-(a-Hydroxy-benzyl)- 542 Methoxy- 678 2-Methyl- 556 Nitro- 672, 678 4-Nitro- 687... 

CJH14N2 56139-76-5) see Tolmetin a-[(dimethylamino)methyl]-4-nitrobenzeneacetic acid (C11H14N2O4 71593-63-0) see Alminoprofen... 

Antitumor properties of some 2-[(dimethylamino)methyl]phenyl-gold(lll) complexes./oumoi of Medicinal Chemistry, 39, 5208. 

Vicente, J., Bermudez, M.D., Chicote, M.T. and Sanchez-Santano, M.J. (1989) Attempts to prepare mixed diarylgold(III) complexes containing a pentafluorophenyl group. Synthesis of [2- (dimethylamino) methyl phenyl-C 1N)-(pentafluorophenyl)gold(III) complexes. Journal of Organometallic Chemistry, 371 (1), 129-135. 

The steroids aldosterone, cortisone, cortisol, 11-P-hydroxyandrostenedione, corticosterone, and rostenedione, 11-desoxycorticosterone, 17-hydroxy-progesterone, and progesterone have been performed on Ultrasphere ODS using methanokwater.19 Ranitidine N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]-methyl]thio]ethyl]-N1-methyl-2-nitro-l,l-ethenediamine has been separated using a p-Bondapak C18 column operated with acetoni-trile methanol water buffered with triethylamine phosphate.117 Pyridoxal-5 -phosphate and other B6 vitamers, including pyridoxamine phosphate, pyri-doxal, pyridoxine, and 4-pyridoxic acid, were separated as bisulfite adducts... 

The structure of [Ir(cod)(dppf)]PF6 shows approximately square-planar geometry at Ir, and the cp rings of the dppf ligand are close to parallel and staggered.592 The systems [Ir(cod)(LL)]C104, where LL = dppf, l-diphenylphosphino-2-(7V,7V-dimethylamino)methyl ferrocene and 1,6-diferrocene-2,5-diazahexane, catalytically trimerize PC=CH to 1,3,5-triphenylbenzene.593 The electrochemistry of [Ir(dppf)2]BPh4 shows two one-electron reductions at —1.560 V and -1.755 V vs. ferrocenium/ ferrocene.753... 

Organometallic compounds containing the bidentate ligand 2-[(dimethylamino) methyl]phenyl(HArN) have been extensively studied. Many subclasses of these... 

As in the case of silanone 9, the reaction of the silylene bis[2-(dimethylamino-methyl) phenyl]silanediyl (8) with phenyl isothiocyanate was examined.29 In this reaction the expected silanethione 36 was obtained as a single product even in the presence of (Me2SiO)3, no insertion product of 36 into a Si-O bond of (Me2SiO)3 was observed (Scheme 10). 

Convert indole to indolyl-3-methyl-ketone (I) by treating indolyl-Mg-Br (preparation already described) with acetyl-Cl, by treating indole in POCl3 with dimethylacetamide (Vilsmeier reaction), or by reacting indole with diketene (ACS 22,1064(1968)). 15.9 g (1) in 50 ml methanol cool, stir and add dropwise 16 g Br2. Reflux 1 Vi hours on water bath cool, filter, wash with ether and recrystallize-methanol to get 18 g indolyl-3-Br-methyl-ketone (II). Dissolve 11.9 g (II) in 60 ml warm isopropanol and add 11 g 3 8% aqueous DMA (or equimoiar amount other amine) reflux one hour on water bath. Filter (recrystallize-ethanol) to get 8.5 g indolyl-3-dimethylamino-methyl ketone (III). Add 4.6 g (0.02 M) (III) in 30 ml tetrahydrofuran to 2.3 g lithium aluminum hydride in 50 ml tetrahydrofuran, stir one-half hour at room temperature and reflux two hours. Add a little water dropwise and extract the precipitate with acetone. Dry, evaporate in vacuum the combined organic phases to get an oil which will precipitate with ether-petroleum ether to give DMT. (Ill) should be tested for psychedelic activity. Dialkyltryptamines BCSJ 11,221 (1936), BSC 2291 (1966)... 

Trisulfuric acid, 23 765 Tris[(dimethylamino)methyl]phenol, 1 536 Tri-t-butoxyalumino hydrides, 13 624 Triterpenoids, 24 555-557 Trithia[9]crown-3, 24 41 Trititanium pentoxide, 25 14... 

Diethyl 7V,./V-dimethylaminomethylenemalonate was obtained in the reaction of di-fm-butyl[bis(dimethylamino)methyl]phosphine and diethyl malonate at 80-100°C for 1 hr in 45% yield (88ZOB1445 89ZOB2206). 

FIGURE 9. MM2-85 calculated torsional potential surface for the two-angle driver of the side chain of (S)-4-hydroxy-2-[(dimethylamino)methyl]indan 70. Reproduced with permission from Reference 108... 

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