5- Methoxy-2- phenol

Diese Methode eignet sich auch fiir die Mononitrierung von 4-Methyl- bzw. 4-Chlor-phenol. Aus 4-Methoxy-phenol erhalt man ausschlieBlich 2,6-Dinitro-phenol. Die Nitrierung von 2-Hydroxy-naphthalin liefert 2-Hydroxy- 1-nitro-naphthalin bzw. 2,6-Dinitro-2-hydroxy-naphthalin in 68 bzw. 32%iger Ausbeute. Die Nitrierung von Hetarenen wie Pyrrol oder Indol fuhrt dagegen selbst bei — 78° zu teerartigen Produkten. 

Auf diese Weise Iassen sich die folgenden Aminomethyl-phenole herstellen (2-Acetyl-, 2-Alkoxycarbonyl- und 4-Methoxy-phenole gehen die Reaktion nicht ein) ... 

A special type of polymeric antioxidant is anoxomer, which consists of 1,4-benzenediol, 2-(l,l-dimethylethyl)-polymer with diethylbenzene, 4-(l,l-dimethyl-ethyl)phenol, 4-methoxy-phenol, 4,4 -(l-methylethylidene)bis(phenol), and 4-methylphenol prepared by condensation polymerization of divinylbenzene (m- and p-) with tert-butylhydroquinone, tert-butylphenol, hy-droxyanisole, p-cresol, and 4,4 -isopropylidenediphenol. Total monomers, dimers, and trimers below 500 are not more than 1%. Anoxomer is permitted in the United States as an antioxidant in food at a level of not more than 5 ppm of fat and oil content of the food. 

It contains a variable proportion of 3-/m-butyl-4-methoxy-phenol. 

Metal-carbon bonds in some Zn and A1 porphyrins, e.g., N-methyltetra-phenylporphinatozinc ethyl and tetraphenylporphinatoaluminium ethyl, can be activated photochemically and undergo substitution reactions with hindered phenols such as 2,6-di-t-butyl-4-methylphenol and 2,6-di-t-butyl-4-methoxy-phenol. The products are metalloporphyrins having a phenoxy-group bound to Zn or Al. Photoexcitation is thought to increase the electron density of the ethyl group bound to the central metal atom and this brings about an enhanced nucleophilicity of the metal-carbon bond. " ... 

Specific compounds detected included propyl-3,4,5 trihydroxy benzoate, 2-tert-butyl-4-methoxy phenol, 2-tert-butylphenol, 2-(ert-butyl-4-methylphenol, and octyl-3,4,5-trihydroxybenzoate. 

In animal organisms, too, chloroneb is degraded into 2,5-dichloro-4-methoxy-phenol and is excreted in the urine in free form or as glucuronide or sulfate... 

Dimethylethyl)-4-methoxyphenol Anisole, butylated hydroxy- Antioxyne B Antrancine 12 BHA BOA (antioxidant) Butyl hydroxyanisole Butylated hydroxyanisole Butylhydroxyanisole 2-terc.Butyl-4-methoxyifenol 2(3)-t-Butyl-4-hydroxyanisole 3-t-Butyl-4-hydroxyanisole t-Butyl hydroxyanisole tert-Butyl-4-hydroxyanisole Butylohydroksyanizol CCRIS 102 EEC No, E320 EINECS 246-563-8 Embanox FEMA No. 2183 HSDB 3913 Nepantiox 1-F Nipantiox 1-F Phenol, 1,1-dimethylethyl)-4-methoxy- Phenol, tert-butyl-4-methoxy- Protex Sustane 1-F Tenox BHA. Mixture of isomers of t-butyl-substituted 4-methoxyphenols antioxidant and preservative for foods mp = 48-55 bp 33 = 264-270 insoluble in H2O, soluble in organic solvents LDm (rat orl) = 2200 mg/kg. Eastman Cham. Co. Mpa Penta Mfg. UOP. 

Styrene (99%, Nacalai Tesque, Japan), MMA (99%, Nacalai), and azobis(isobutyronitrile) (AIBN) (99%, Nacalai) were purified by distillation or recrystallization. 1-Phenylethyl iodide (PE-1) and 2-cyanopropyl iodide (CP-1) were prepared according to Matyjaszewski (9) and Balczewski (10), respectively. 2,2 -Azobis(2,4,4-trimethylpentane) (VRllO) (99.9%, Wako Pure Chemical, Japan), f-butyl peibenzoate (BPB) (98%, Aldrich), di(4-f-butylcyclohexyl) peroxydicarbonate (PERKADOX16) (95%, Akzo), thymol iodide (TI) (95%, Wako), 2,4,6-trimethyl phenol (2,4,6-Me) (97%, Wako), 2,6-di-f-butyl-4-methyl phenol (3,5-di-f-butyl-4-hydroxy toluene (BUT)) (98%, Wako), 2,6-di-i-butyl-4-methoxy phenol (3,5-di-i-butyl-4-hydroxy anisole (BHA)) (97%, Aldrich), phenol (99%, Wako), vitamin E (VE) (99.5%, Wako), vitamin C (VC) (99%, Tokyo Kasei, Japan), and 2,2,6,6-tetramethylpiperidinyl-l-oxy (TEMPO) (99%, Aldrich) were used as received. 

Phenol, 3-(1,1-dimethyethyl)-4-methoxy-Phenol, 3-(1-propenyl)-Phenol, 3-propyl-Phenol, 4-(1,1-dimethylethyl)-... 

Other phenols and phenol ethers were examined to assess the breadth of activity of this catalyst. Anisole was selected as an electron rich aromatic system though less so than phenol. A cleaner reaction at lower conversion was expected. Under similar conditions employed for phenol hydroxylation, a 20% conversion of anisole was measured with selectivity to 4-methoxy phenol of 15% and to guiacol of 42%. 1-naphthol was also assessed. No conversion was seen, presumably due to the bulky nature of the molecule. These findings are consistent with a mechanism involving an electrophilic oxidant species. 

Toxicology Exposure is by inhalation. 4-Methoxy phenol is a cytotoxic and a narcotic at high exposures. It is a carcinogen for animals, but no data is available for humans [47]. 

Butyl-4-hydroxybtrnzMle n-Butyl methaccylate 4-tert-ButyM -merhoxydibenzoyl methane 2-terr-Buty -4-methoxy phenol 4-terr-Butyl phenol... 

Han, J.K., Miltz, J., Harte, B.R., Giacin, J.R. and Gray, J.T. (1987) Loss of 2-tertiary-butyl-4-methoxy phenol (BHA) from high-density polyethylene film. Polym. Eng. Scl 27, 934-938. 

Catalytic activities of biocomposite materials derived from a-ZrP are collected in Table 9 these are comparable to the corresponding activities of the native proteins in aqueous solutions. In some cases they are enhanced for example, the peroxidase activity of bound Mb is greater when 4-methoxy phenol, and other para-substituted phenols were used as substrates (256). This is one of the rare examples where the bound protein had a higher activity. The catalytic data provided later clearly establish the versatility of a-ZrP in providing a benign medium for the incorporation of delicate proteins/enzymes for biocatalytic applications. 

Also obtained by reaction of methoxyacetonitrile with 3,5-diethoxy-4-methoxy-phenol (Hoesch reaction) [4917], (7%) [4918],... 

Hwang, S.-M. Lee, M.-J. Lin, H.-M. Isothermal vapor-hquid equilibria for mixtures of 4-methoxy-phenol, eatechol, and p-cresol. Fluid Phase EquiUb. 2000, 172, 183-196. 

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