5-Amino-5-phcnyl

Amino-phenyl)-2-methylthio- 79 2-(2-Amino-phenyl)-4-phenyl- 199 2-(5-Amino-4-phenyl-pyrazolo)-4-phenyl- 62 2-Amino-4-phcnyl-5-(N-su1fo-hydroxamino)- 247 2-Amino-4-phcnyl-5-thioeyanat- 109... 

AthyI-(4-amino-phcnyl)- 684 Athyl-benzyl- 500 Bis-[4-brom-phenyI]- 572 Bis-[4-chlor-phenyl]- 488 Bis-[4-hydroxy-phenyl]- 572 Bis-14-methoxy-phenyl]- 572 Bis-[4-methyl-phenyl]- 572 Bis-[4-nitro-phenyl]- 572 a-Brom- 534f. 

Amino-phcnyl)-2-hydroxy-l,3,4-oxadiazol (R1 =2-NH2 R2 = H)179 1,11 g (0,005mol) Kohlensiiure-[2-(2-amino-benzoyl)-hydrazid]-dimethylamid wind in 11 ml DMF gclost und 2 h unter RiickfluB erhitzt, ge-kiihlt, 50 m/Wasserzur Reaktionslosunggegebenund 1 him Eisbad belasscn. Manfiltricrt und kristallisiert die erhaltene Substanz aus Ethanol um Ausbeute 0,62 g (70%) Schmp. 174-175° (Ethanol/Wasser). 

Dimethyl-2-hydroxy-2-(4-methyl-amino-phcnyl)-l-(2-phenyl-ethylamino)- 106... 

Die analoge Reaktion in der Chinazolin-Reihe fiihrt fiber isolierbare 1,3-Thiazolo-chinazoli-nium-Salze und weiter fiber 2-(2-Formylamino-phenyl)-l,3-thiazole zu 2-(2-Amino-phcnyl)-l,3-thiazolen974-992 ... 

Bis-f2-hydroxy-athyl]-(4-amino-phcnyl)- 532 Bis-[ 2-hydroxy-athyl]-(4-nitro-phenyl)- 532 Bis-findanyl-(2)]- 252 Bis-f2-(bzw. 4)-methyl-cyclohexyl]- 442 Bis-f2-methyl-cyclohexyl]- 542 Bis-fnaphthyl-(2)-methyl]- 2.30 Bis-[2-nitro-3-methoxy-phenylJ- 5/7 Bis-[3-pentyloxy-propylj- 126 Bis-f 4-phenoxy-butylf- 126 Bis-f7-phenoxy-heptylj- 126 Bis-f6-phenoxy-hexyl]- 126 Bis-[3-(2-phenyl-athoxy)-propyl]- 126 Bis-[5,6,7,8-tetrahydro-chinolyl-(3)-methyl]- 127 Bis-[6,7,8.9-tetrahydro-5H-(cyclohepta-[b]-pyridin)-3-ylmethyl]- 127 Bis-fl-thienyl-(2)-athyl]- 430 (2-Brom-phenyl)-(4-nitro-benzyliden)- 607 Butyl- 27, 118, 413, 418... 

In asymmetric Strecker synthesis ( + )-(45,55 )-5-amino-2,2-dimethyl-4-phenyl-l,3-dioxane has been introduced as an alternative chiral auxiliary47. The compound is readily accessible from (lS,25)-2-amino-l-phcnyl-l,3-propancdioI, an intermediate in the industrial production of chloramphenicol, by acctalization with acetone. This chiral amine reacts smoothly with methyl ketones of the arylalkyl47 or alkyl series48 and sodium cyanide, after addition of acetic acid, to afford a-methyl-a-amino nitriles in high yield and in diastereomerically pure form. 

Methyl-phenyIthio)-(4-nitro-phenyl)- 700 (2-Nitro-phcnyl)-(2-hydroxy-5-methyl-phenyl)- 693 (2-Nitro-phenyl)-(4-methoxy-phenyl)- 693 (2-Nitro-phenyl)-(4-methyl-phenyl)- 693 Phenyl-(4-amino-phenyl)- 568 Ph en yl-(4-formyl-phenyl) -... 

CN 2-[[[4-[[[[(hydroxymethyl)amino]carbonyl]amino]sulfonyl]phcnyl]amino]carbonyl.Ibenzoic acitl... 

Fig. 10 Structures of dyes (a) 3,3 -di(3-sulfopropyl)-9-amino-thiacarbocyanine (dye 8), (b) 3,3 -di(3-sulfopropyl)-4,5,4, 5 -dibenzo-9-phcnyl-thiacarbocyanine (PTC), (c) meso-tetrakis(p-sulfo-natophenyl) porphine (TSPP, at pH lower than 4.8)...

A stirred solution of 13.0 g (100 mmol) of 5-oxohexanoic acid and 17.5 g of (1, S. 2.S )-2-amino-1-phcnyl-1,3-propanediol is heated under reflux in benzene for 16 h with azeotropic removal of water. The solution is concentrated and the residue is dissolved in 600 mL of diethyl ether. The solution is washed with sat. aq NH4C1, water, sat. aq Na2C03 and brine before drying over MgS04 and concentration in vacuo to give a colorless oil yield 24 g (96%) 84 14 2 mixture of isomers (the major isomers are diastereomers while the minor isomer is a regioisomer). Rccrystallization from ethyl acetate/hexane furnishes colorless needles yield 15.7g(60%) mp98-99°C [ ]D +13.3 (c = 1.1, ethanol). 

---