Hydrocortisone phosphate

J. Korpi, D. P. Wittmer, B. J. Sandman, and W. C. Haney, Simultaneous analysis of hydrocortisone and hydrocortisone phosphate by high-pressure liquid chromatography Reversed-phase, ion-pair approach, J. Pharm. Sci., 65 1087 (1976). 

In a double-bhnd study it was found that a single intravenous injection of hydrocortisone phosphate resulted in anorectal pruritus, which was not seen following hydrocortisone succinate or placebo (106 ). The pharmacological basis is unknown. 

The eluate was titrated to pH 7 with 0572N NaOH (63 ml). Removal of solvent left a gum, which was boiled with methanol (400 ml) for 20 minutes. The solid insoluble inorganic phosphate was filtered off and washed with methanol (200 ml). The slightly cloudy filtrate was filtered again, and evaporated to dryness in vacuo. The residual gum dissolved readily in water (40 ml) and on addition of acetone (600 ml) to the solution a mixture of sodium salts of hydrocortisone 21 -phosphate separated as a white solid. This was collected after 2 days, washed with acetone and dried at 100°C/0.1 mm/2 hrto constant weight. Yield4.45g. 

C2 H3()05 50-23-7) see Bcndacort Cloprednol Desonide Hydrocortisone acetate Hydrocortisone 17-butyrate Hydrocortisone sodium phosphate Methylprednisolone Prednisolone... 

Administer hydrocortisone sodium phosphate or hydrocortisone sodium succinate, 100 mg intravenously every 6 to 8 hours for 24 hours. 

Hydrocortisone is used in the form of a free alcohol (speaking of the hydroxyl group at Cji), as well as in the form of an acetate, succinate, or phosphate [8]. 

Admixture incompatibilities - Magnesium sulfate in solution may result in a precipitate formation when mixed with solutions containing Alcohol (in high concentrations) alkali carbonates and bicarbonates alkali hydroxides arsenates barium calcium clindamycin phosphate heavy metals hydrocortisone sodium succinate phosphates polymyxin B sulfate procaine hydrochloride salicylates strontium tartrates. 

Hydrocortisone sodium phosphate - Administer by IV, IM, or subcutaneous injection. Initial dose is 15 to 240 mg/day. Usually, 33% to 50% of the oral dose every 12 hours. For acute diseases, doses greater than 240 mg may be required. 

Physically compatible up to 48 hours - Ascorbic acid benztropine cytarabine dexamethasone sodium phosphate diphenhydramine doxorubicin heparin sodium hydrocortisone sodium phosphate lidocaine magnesium sulfate multivitamin infusion (must be refrigerated) vitamin B complex with ascorbic acid. 

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