Hydrochloride Inhalation Solution

Xopenex (levalbuterol HC1) inhalation solution is supplied in unit-dose vials and requires no dilution before administration by nebulization. Each 3-mL unit-dose vial contains either 0.63 mg of levalbuterol (as 0.73 mg of leval- 

Each 118-mL container of Camitor (levocarnitine) oral solution contains 1 g of levocamitine/10 mL. It also contains artificial cherry flavor, D,L-malic acid, purified water, 

Zyvox for oral suspension is supplied as an orange-flavored granule/powder for constitution into a suspension for oral administration. Following constitution, each 5 mL contains 100 mg of linezolid. Inactive ingredients are 

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LEVALBUTEROL HYDROCHLORIDE (Xopenex solution of inhalation 0.31 mg levalbuterol per 3 mL, solution for inhalation 0.63 mg levalbuterol per 3 mL)... 

As an illegal drug, cocaine occurs in different forms. The hydrochloride is soluble in water and can be injected, sniffed, or chewed. Freebase is cocaine base, which is gained by extraction of cocaine from alkaline solutions with ether. It evaporates at high temperatures and can be inhaled by smoking. Another smok-able form of the cocaine base is crack , which is obtained by precipitating cocaine hydrochloride from solution with baking soda. 

Drug solutions and implantation of osmotic mini-pumps Physostigmine hemisulphate and procyclidine hydrochlorid were obtained from Sigma (St.Louis, U.S.A.), scopolamine hydrobromid from Merck (Darmstadt, Germany), atropine sulphate was obtained from ACF (Amsterdam, The Netherlands), and diazepam from Roche (The Netherlands). HI-6 was made available by the Defence Research Establishment, Suffield, Canada. Soman (O-pinacolyl methylphosphonofluoridate) was synthesised at TNO. Alzet Osmotic Mini-pumps with a constant delivery rate of 0.55 pl/hr (Model 2002, Alza Corp., Palo Alto, USA) were used to deliver PYR, PHY and SCO. The vehicle consisted of 20% propylene glycol, 10% ethanol and 70% water. The pumps were implanted subcutaneously under isoflurane/02 inhalation anesthesia. 

Solution for inhalation 1 100 (10 mg/mL as hydrochloride) (Rx) Adrenalin Chloride Solution (Monarch)... 

Cocaine hydrochloride is a water-soluble salt that can be injected or absorbed by any mucosal membrane (eg, nasal snorting). When heated in an alkaline solution, it is transformed into the free base, "crack cocaine," which can then be smoked. Inhaled crack cocaine is rapidly absorbed in the lungs and penetrates swiftly into the brain, producing an almost instantaneous "rush."... 

Oxymetazoline hydrochloride is toxic. There is a risk of serious intoxication if inhaled or swallowed. This product is a colorless, odorless membrane-filtered solution. Thus, make sure that the receiving tank for the filtered solution is cleaned and free of any contamination. 

Selegiline hydrochloride Semduramycin sodium Serenda repcus, serenovarepens Sertraline hydrochloride Sevoflurene inhalation Sibutramine hydrochloride Sildenafil citrate Silymarin Simvastatin Sodium enoxaparin Sodium picosulfate Solution/nasal spray/injection... 

Epinephrine. Epinephrine (Adrenalin) finds use in a number of situations because of its potent stimulatory effects on both a- and /3-adrcncrgic receptors. Like the other catecholamines, epinephrine is light sensitive and easily oxidized on exposure to air because of the catechol ring system. The development of a pink to brown color indicates oxidative breakdown. To minimize oxidation, solutions of the drug are. stabilized by the addition of reducing agents such as sodium bisulfite. As the free amine, it is used in aqueous solution for inhalation. Like other amines, it forms salts with acids, for example, those now used include the hydrochloride and the bitartratc. Epinephrine is destroyed readily in alkaline solutions and by metals (c.g.. Cu, Fe, Zn), weak... 

Table 6.16 shows solubility data for an inhalation candidate drug (secondary amine hydrochloride), which was to be delivered by a pMDI and as a nebulizer solution. 

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