Hyaluronidase hyaluronate

Hyaluronidase Hyaluronic acid and chrondroitin sulfate (Chap. 2) Liver... 

Seifter, J., and Baeder, D. H., Lipemia clearing by hyaluronidase, hyaluronate, and desoxycorticosterone, and its inhibition by cortisone, stress, and nephrosis. Proc. Soc. Exptl. Biol. Med. 86, 709-713 (1954). 

Effect of Streptomyces hyaluronidase. The effects of some depolymerizing enzymes on the viscoelastic properties of proteoglycan were examined. The first example was that of Streptomyces hyaluronidase (hyaluronate lyase, EC 4.2.2.1.), which is shown as strictly specific to hyaluronic acid (j6). Thus this enzyme can degrade only the hyaluronic acid backbone of aggregate and should not attack the proteoglycan monomer. To 0.1% solution of aggregate 0.05TRU of Streptomyces hyaluronidase was added. As... 

A recent paper (Reppert et al., 1951) has drawn attention to the remarkable speed with which ascorbic acid corrects the increased capillary fragility in scurvy. It is argued that this could hardly allow time for the repair of intercellular cement substance and suggests rather a direct chemical or enzymic response. Some experiments, reported in the barest outline, claim to show that ascorbic acid in large doses inhibits the hyaluronidase-hyaluronic reaction in rabbits and, to a small extent, in vitro. It is suggested that this inhibition of the spreading factor may account for the rapid improvement in capillary fragility. Obviously more experimental evidence is needed before this supposition can be seriously considered. 

Puhvel SM and Reisner RM (1972) The production of hyaluronidase (hyaluronate lyase) by Corynebacterium acnes. J Invest Dermatol 58 66-70 Pulverer G and Ko HL (1973) Fermentative and serological studies on Propionibacterium acnes. Appl Microbiol 25 222-229... 

Hyaluronidase Hyaluronic acid, hyaluronic acid saccharides... 

The literature on chemical and biolo cal aspects of the hyaluronidase-hyaluronic acid system has been admirably reviewed by Meyer (119) and by Meyer and Rapport (132). Many other important general reviews as well as discussions of special topics have been published (31,35,44,114,178,... 

The second type of material includes spores, which may or may not produce disease symptoms but which can germinate in the insect gut and give rise to vegetative bacterial cells which in turn may produce, and exoenzymes such as phospholipases (lecithinases) or hyaluronidase. The phospholipases may produce direct toxic symptoms owing to their action on nervous or other phospholipid-containing tissue. Hyaluronidase breaks down hyaluronic acid and produces effects on animal tissue which are morphologically similar to the breakdown of insect gut wall in the presence of microbial insecticide preparations. 

Hyaluronidase and streptokinase are produced by the haemolytic streptococci and enable the organism to spread rapidly through the tissue. Hyaluronidase dissolves hyaluronic acid (intercellular cement), whereas streptokinase (Chapter 25) dissolves blood clots. 

The PL-catechin conjugate showed greatly amplified concentration-dependent inhibition activity against bacterial collagenase (ChC) on the basis of the catechin unit, which is considered to be due to effective multivalent interaction between ChC and the catechin unit in the conjugate. The kinetic study suggests that this conjugate is a mixed-type inhibitor for ChC. Hyaluronidase is an enzyme which catalyzes hydrolysis of hyaluronic acid and is often involved in a number... 

Hyaluronidase is the antidote of choice for vinca alkaloid and high-concentration epipodophyllotoxin extravasations. Hyaluronidase breaks down hyaluronic acid, which functions as tissue cement. This promotes absorption of the extravasated drug away from the local site. Hyaluronidase also may be used for paclitaxel extravasations, but there are conflicting reports regarding its efficacy.39 Hyaluronidase should not be used with anthracycline extravasations because enhancement of local spread may occur. 

The action of spreading factors, e. g., hyaluronidases on hyaluronic acid both in vivo and in vitro is often quite dramatic, and the effect in vitro appears to go in three stages (a) a separation of the protein residue ... 

Hyaluronic Add Sulfate.—Meyer and Chaffee108 showed that this mucopolysaccharide of the cornea was a true derivative of hyaluronic acid, since it could be hydrolyzed enzymically by what is now known as hyaluronidase. ... 

Even less is known about the effects of ozone on carbohydrates. Buell et al. observed a decrease in the depolymerization of hyaluronic acid after treatment of the lungs of ozone-exposed rabbits (1 ppm for 1 h) with hyaluronidase. B. Goldstein et al. reported a loss in membrane neuraminic acid of red cells exposed in vitro to high concentrations of ozone. It would be important to study the effects of ozone on respiratory tract mucus, which is rich in carbohydrates, including neuraminic acid. This could indude determination of foe extent to which ozone is able to penetrate mucus that is unaltered, whether foe reaction of ozone with mucus results in the formation of cytotoxic intermediates, and evaluation of the interaction in mucus of ozone with other air pollutants, particularly sulfur dioxide. Of possible pertinence is a study by Falk et who observed that ozone produced a loss in foe viral hemagglutinating ability of snail mucus. 

This enzyme [EC 4.2.2.1], also known as hyaluronidase, catalyzes the conversion of hyaluronate to n 3-(4-deoxy-... 

HUGHES-INGOLD THEORY EOR SOLVENT EEEECTS ON REACTIVITY HUMMEL-DREYER TECHNIQUE HYALURONATE LYASE HYALURONIDASES HYBRIDIZATION HYDRATION ATMOSPHERE HYDRATION NUMBER Hydrazone reduction,... 

M sodium chloride oligosaccharides from hyaluronidase degradation of hyaluronic acid 89... 

By constricting the vascular bed, such coadministered vasoactive excipients as epinephrine can reduce the rate of uptake from the SC sites (4a). By contrast, the excipient hyaluronidase breaks down the interstitial barrier by lysing hyaluronic acid, a polysaccharide that helps form the intercellular ground substance of connective tissue (4b). This in effect spreads the injected drug solution over a larger area of connective tissue, increasing the absorption surface, and thereby increasing both the volume that can normally be injected SC (Table 1) and the rate of uptake (6). 

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