Corynebacterium acnes

During the next eight years, Fleming learnt much about the techniques of vaccine preparation and of bacteriology, and even produced his own vaccine against the bacterium Corynebacterium acnes, which is usually involved in facial acne. His promising therapeutic results were described in a paper for the Lancet (1909), and his involvement with the clinical trials of Salvarsan... 

Douglas HC and Gunter SE (1946) The taxonomic position of Corynebacterium acnes. J Bacteiiol 52 15-23... 

Moss CW, Dowell VR, Farshthi D, Raines LJ and Cherry WB (1967) Cultural characteristics and fatty acid composition of Corynebacterium acnes. J Bacteriol 94 1300-1305 Moss CW, Dowell VR, Lewis VJ and Schekter MA (1969) Cultural characteristics and fatty acid composition of propionibacteria. J Bacteriol 97 561-570 Murakami K, Hashimoto Y and Murooka Y (1993) Cloning and characterization of the gene encoding glutamate 1-semialdehyde 2,1-aminomutase, which is involved in 6-aminolevulinic acid synthesis in Propionibacterium freudenreichii. Appl Environ Microbiol 59 347-350... 

Plastourgos S and Vaughn RH (1957) Species of Propionibacterium associated Avith Zapateria spoilage of olives. Appl Microbiol 5 262-271 Pochi PE and Stauss JS (1961) Antibiotic sensitivity of Corynebacterium acnes Propionibacterium acnes). J Invest Dermatol 36 423-429 Polulach OV (1987) Biosynthesis of tetrapyrrole compounds (porphyrins and vitamin 612) by some representatives of genus Propionibacterium. PhD thesis, Moscow State University, Moscow... 

Puhvel SM and Reisner RM (1972) The production of hyaluronidase (hyaluronate lyase) by Corynebacterium acnes. J Invest Dermatol 58 66-70 Pulverer G and Ko HL (1973) Fermentative and serological studies on Propionibacterium acnes. Appl Microbiol 25 222-229... 

Definite evidence has recently been found that oleic acid plays a part in the growth requirements of several micro-organisms. Fleming in 1909 (94) observed that the acne bacillus (Corynebacterium acnes), which is difficult to cultivate, grew best in ordinary nutrient agar to which 1-5% oleic acid was added. 

Etiology. Microbiologic studies of lid flora in control and blepharitis patients determined that the most common bacteria isolated from both groups were staphylococcal epidermidis (5, epidermidis ), Propionibacterium acnes, and Corynebacterium sp. S. aureus was cultured more often in the infectious and mixed varieties of... 

Identification of AcnR, a TetR-type repressor of the aconitase gene acn in Corynebacterium glutamicum. 

On the other hand, the boundaries of the genus were extended by including four species of anaerobic corynebacteria that inhabit human skin. Using the methods of traditional, numerical and molecular taxonomy, anaerobic corynebacteria were shown to be different from the other members of the genus Corynebacterium by a number of essential characteristics and to have genomic similarities with propionic acid bacteria. The anaerobic corynebacteria have been reclassified as P. acnes, P. avidum, P. granulosum and P. lymphophilum and are called cutaneous propionibacteria now. 

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