Human leukocyte interferon

Nagata S, Taira H, Hall A, Johnsrud L, Streuli M, Ecsodi J, Boll W, CanteU K, Weissmann C (1980) Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature 284 316-320... 

Goeddel D.V., Yelverton E., Ullrich A, Heyneker H.L., Miozzari G., Holmes W., Seeburg P.J., Dull T., May L, Stebbing N., Crea R., Maeda S., McCandliss R, Sloma A, Tabor J.M., Gross M., Eamilletti P.C. Pestka S. (1980) Human leukocyte interferon produced by E. coli is biologically active. Nature, 287,411-416. 

Karau, C., Pongpaibul, Y, and Schmidt, PC., Quantitative evaluation of human leukocyte interferon-entrapped in liposomes, Drug Delivery, 3, 59-62, 1996. 

Tamura, M., and S. Sasakawa, Induction of human leukocyte interferon by heat-treated poly I poly C. Biochem Biophys Res Commun, 1983.110(3) 851-8. 

Cantell, K., S. Hirvonen, K.E. Mogensen, and L. Pyhala, Human leukocyte interferon production, purification, stability, and animal experiments. In vitro Monogr, 1974. 3 35-8. 

Rubinstein, M., S. Rubinstein, PC. Familletti, R.S. Miller, A.A. Waldman, and S. Pestka, Human leukocyte interferon production, purification to homogeneity, and initial characterization. Proc Natl Acad Sci USA, 1979.76(2) 640-4. 

Rubinstein, M., WP. Levy, J.A. Moschera, C.Y. Lai, R.D. Hershberg, R.T. Bartlett, and S. Pestka, Human leukocyte interferon isolation and characterization of several molecular forms. Arch Biochem Biophys, 1981. 210(1) 307-18. 

Pish, E.N., K. Banerjee, and N. Stebbing, Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells. Biochem Biophys Res Commun, 1983.112(2) 537 6. 

Salmon, S.E., B.G. Durie, L. Young, R.M. Liu, P.W. Trown, and N. Stebbing, Effects of cloned human leukocyte interferons in the human tumor stem cell assay. I Clin Oncol, 1983.1(3) 217-25. 

Greenberg, H.B., R.B. Pollard, L.I. Lutwick, PB. Gregory, W.S. Robinson, and T.C. Merigan, Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. New Engl J Med, 1976. 295 517-22. 

Goeddel, D.V., E. Yelverton, A. Ullrich, et al.. Human leukocyte interferon produced by E. coli is biologically active. Natnre, 1980. 287 411-67. 

The globular protein human leukocyte interferon (containing 156 residues) is being treated by the build-up procedure.146 Thus far, approximately two thirds of the molecule has been built up. 

Adams F, Quesada JR, Gutterman JU. Neuropsychiatric manifestations of human leukocyte interferon therapy in patients with cancer. JAMA 1984 252(7) 938 fl. 

Colivicchi F, Magnanimi S, Sebastiani F, Silvestri R, Magnanimi R. Incidence of electrocardiographic abnormalities during treatment with human leukocyte interferon-alfa in patients with chronic hepatitis C but without preexisting cardiovascular disease. Curr Ther Res Clin Exp 1998 59 692-6. 

Kauppila A, Cantell K, Janne O, Kokko E, Vihko R. Serum sex steroid and peptide hormone concentrations, and endometrial estrogen and progestin receptor levels during administration of human leukocyte interferon. Int J Cancer 1982 29(3) 291. ... 

Ingimarsson S, Cantell K, Strander H. Side effects of longterm treatment with human leukocyte interferon. J Infect Dis 1979 140(4) 560-3. 

Cheeseman SH, Rubin RH, Stewart JA, Tolkoff-Rubin NE, Cosimi AB, Cantell K, Gilbert J, Winkle S, Herrin JT, Black PH, Russell PS, Hirsch MS. Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation. Effects on cytomegalovirus and herpes simplex virus infections. N Engl J Med 1979 300(24) 1345-9. 

Kahn, F. R. Ballon, P. Koplove, M. Rai, V. R. "Large-Scale Purification of Recombinant Human Leukocyte Interferon (rIFN-a-2a) Using Monoclonal Antibodies" Paper presented at the ACS meeting. New Orleans, Aug. 30 - Sept. 4, 1987. 

Rosenblum, M.G., Unger, B.W., Gutterman, J.U., Hersh, E.M., David, G.S., and Frincke, J.M. (1985) Modification of human leukocyte interferon pharmacology with a mono clonal antibody. Cancer Research, 45, 2421 2424. 

USA interferon alfa-n3 interferon Alferon N Alferon LDO, Altemol, Cellferon Natural human leukocyte interferon alpha-n3 variant with approximately 166 amino acids with molecular weights in the range 16—27 kDa Antiviral... 

Rosenberg N, Reichman M, Gera A, et al. Antiviral activity of natural and recombinant human leukocyte interferons in tobacco protoplasts. Virology, 1985 140(1) 173-178. 

B47. Blalock, J. E., and Smith, E. M. Human leukocyte interferon (HuIFN-alpha) Potent endorphinlike opioid activity. Biochem. Biophys. Res. Commun. 101, 472—478 (1981). 

Rosenblum MG, Unger BW, Gntterman JU, Hersh EM, David GS, Frincke JM. Modification of human leukocyte interferon pharmacology with a monoclonal antibody. 

HTLC HTLV III HTN HTP HTR HTVD HUIFM HUR HUS HV H V HW hwb Hx Hz HZ HZO human T-cell leukemia virus human T-cell lymphotrophic virus type III hypertension House-Tree-Person test acute hemolytic transfusion reaction hypertensive vascular disease human leukocyte interferon meloy hemolytic uremic syndrome hemolytic uremic syndrome hallux valgus has voided hemigastrectomy and vagotomy heparin well housewife hot water bottle history hospitalization Hertz herpes zoster herpes zoster ophthalmicus... 

Nakagawa, S. Honda, S. Sugino, H. Kusumoto, S. Sasaoki, K. Nishi, K. Kakinuma, A. Characterization of three species of Escherichia coli-derived human leukocyte interferon A separated by reverse-phase high-performance liquid chromatography. J.Interferon.Res., 1987, 7, 285-299... 

Cantell K, Pyhala L (1976). Pharmacokinetics of human leukocyte interferon. /. Infect. Dis. 133(suppl A) A6-A12. 

Perkinsdon A, Lasker J, Kramer M J, et al. (1982). Effects of three recombinant human leukocyte interferons on drug metabolism in mice. Drug. Metab. Dispos. 10 579-585. 

In this method the sample is applied to the column in a less polar solvent and eluted with a gradient of increasing polarity. Different species of human leukocyte interferon were separated on a Lichrosorb diol column with a gradient of decreasing n-propanol concentration (Rubinstein et a/., 1979). The Lichrosorb NH2 column has been used in the normal-phase mode for resolving amino acid mixtures (Schuster, 1980). 

Human fibroblast and leukocyte interferons show a strong affinity for the copper chelate of bis-carboxymethylaminoagarose. Human leukocyte interferon adsorbs non-specifically to immobilized hyperimmune serum immunoglobulin The interferon can be recovered by washing the adsorbent with 1,2-dihydroxyethane. An improved procedure for the isolation of interferons produced by mouse Ehrlich ascites tumour cells infected with Newcastle disease virus provides interferons of three size classes (mol. wts. 3.3 X lO", 2.6x10, ... 

Leptin, human Leptin, mouse Calcitonin, salmon Interferon alpha, human leukocyte Interferon omega, human Interferon alpha 2a, human Interferon alpha 2c, human Interferon alpha 2b, human Interferon alpha consensus, human Interferon alpha... 

It was found that human fibroblast interferon binds strongly to Zn +-IDA, unlike human leukocyte interferon, which was not retained on such a column [78]. Syrian hamster interferon did not bind to Zn -IDA but was retained on Cu -IDA [77]. The latter column also strongly bound human fibroblast and human leukocyte interferons [85], Figure 10 illustrates the separation of mouse L-cell interferons on a Cu -IDA agarose column [48]. 

We will now briefly illustrate an abstracted stepwise scheme that may be followed for recovery and purification of an intracellular product (Figure 11.1.2). Typical examples of intracellular products are human insulin (a hormone, MW 5734), bovine growth hormone, human growth hormone (HGH), human leukocyte interferon, glucose iso-merase from Streptomyces species, hemoglobin from red blood cells. 

Interferon - Human interferon was shown to have a limited but measurable activity against a number of strains of adenovirus. The absence of interferon in serial serum specimens collected prior to and during the incubation and acute phase of transfusion associated hepatitis may in part be related to the chronicity of the disease. Human leukocytal interferon has been utilized in at least two controlled clinical trials. In the first trial it was administered to patients with confirmed Influenza and found to rapidly and dramatically reduce the systemic symptoms (headache, dizziness, malaise) and to a lesser degree the respiratory tract symptoms. 

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