Human eczema

After 14 hours besides an extensive spongiosis, as described by Miescher (1962) (Fig. 12), and sometimes a spongiosis in clusters as in human eczema, we note... 

In human eczema, positive reactions with alkaline phosphatase have similarly been observed in the cells of the infiltrate (Fisher and Click, 1947 Pirila and Eranko, 1950 Kopf, 1957) and in the capillaries of the papillary layer (Nishivama, 1963). 

This description of human eczema by Lever (1961) corresponds to the description of the bullae and vesicles observed in the eczema of the guinea pig s nipple. 

An infiltrate composed of histiocytes has also been frequently noticed in human eczema (Cans and Steigleder, 1955). 

Experiments on guinea pig eczema are very important, not only as basic research but also from a practical point of view, for guinea pig eczema has many analogies with human eczema. If Dr. Hunziker s monograph can stimulate new experiments in this domain or facilitate other work in this field, then her efforts may be considered as worthwhile. 

The symptoms of many chronic diseases, such as rheumatoid arthritis, multiple sclerosis, asthma and chronic obstructive pulmonary disease (COPD) are caused in large part by an excessive and chronic inflammatory response and are therefore potential human diseases for drugs which inhibit the SSAO/VAP-1 activity. Notably, it has been recently shown that patients suffering from either atopic eczema or psoriasis, both chronic inflammatory skin disorders, demonstrate an increase in SSAO/VAP-1 positive vessels in their skin compared to skin from healthy controls [47,48]. 

Although ciclosporin and tacrolimus applied systemically improve psoriatic lesions, they are clearly less active when applied topically. Therefore, liposomal preparations have been developed. Indeed, ciclosporin penetrates deeper strata of rodent and human cadaver skin more efficiently when incorporated into liposomes [51], Moreover, tacrolimus concentrations in murine skin have increased ninefold, and skin graft survival prolonged, if the drug is liposome encapsulated [52]. This indicates that topical psoriasis therapy with tacrolimus may become possible. At present, topical tacrolimus is confined to the less recalcitrant forms of mild eczema. 

No serious poisonings with decalin in humans have been reported. Inhalation of 100 ppm produces upper respiratory irritation. Contact with the liquid produced vesicular eczema, accompanied by intense itching, in a worker exposed to decalin and some detergents. ... 

Scabies. A contagious dermatitis of humans and various animals, caused by the itch mite, Sarcoptes scabiei, and characterized by a popular eruption over tiny, raised sinuous burrows produced by digging into the upper layer of the epidermis by the egg-laying female mite, which is accompanied by intense pruritus and sometimes associated with eczema and secondary bacterial infection. 

In humans, produces eczema-like allergic reactions.3 Carcinogen in mice, rats, hamsters, and dogs. Ingestion in these animals produces liver, bladder, and lung tumors. Reasonably anticipated to be a human carcinogen.4... 

Forster, S., Ilderton, E., and Norris J.F.B., Characterisation and activity of phospholipase A2 in normal human epidermis and in lesion free epidermis of patients with psoriasis or eczema, Br. J. Dermatol., 112, 135, 1985. 

Acute inhalation exposure may result in sensitization and asthma in humans. Dermal contact with MDI resulted in dermatitis and eczema in plant workers. Animal studies revealed skin and eye irritation in rabbits, extreme toxicity by inhalation and moderate toxicity by oral ingestion in rodents. 

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