Human Chorionic Gonadotrophin hCG

If fertilisation does not occur, the corpus luteum regresses and the levels of oestrogen and progesterone fall. However, if fertilisation does occur, the corpus luteum is maintained. Regression of the corpus luteum is prevented by the implanting blastocyst which secretes a hormone, human chorionic gonadotrophin (hCG). This occurs about a week after fertilisation. The structure of this hormone is similar to that of LH and it takes on the role of LH in maintenance of the corpus luteum. To do this, it binds to the LH receptor... [Pg.444]

Follicle stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic gonadotrophin (hCG)... [Pg.331]

It is to be expected that these extremely widely used oral methods of contraception will eventually be replaced by luteinizing hormone analogs as antiovulatory agents, or possibly by immunological methods directed against human chorionic gonadotrophin (hCG), which has both LH and FSH activity. Prostaglandins also show promise, and reliable male contraception is also a future possibility. [Pg.328]

Human chorionic gonadotrophin (hCG) Competitive immunoassay on Nafion-coated SPCEs in microwells DPV oxidation of accumulated cationic product of substrate hydrolysis by ALP enzyme Scan from Oto +0.7V 200-10,000 mlUmP1 100 mlU (lmg= 9825 IU) Bagel et al. [75]... [Pg.510]

Chorionic gonadotrophin (human chorionic gonadotrophin HCG) is secreted by the placenta and is obtained from the urine of pregnant women. Its predominant action is that of luteinising hormone (LH) (interstitial cell stimulating hormone) which induces progesterone production by the corpus luteum and, in the male, gonadal testosterone... [Pg.711]

Gynecomastia is frequent in men with testicular tumors that produce large amounts of human chorionic gonadotrophin (HCG), and its appearance after completion of chemotherapy may indicate residual or recurrent disease. However, not uncommonly, gynecomastia is a harmless, although troubling, late adverse effect of chemotherapy. In 16 patients who developed gynecomastia... [Pg.1039]

Anterior pituitary hormones are classihed into three families the somatomammotropin family (GH and PRL), the glycoprotein hormones (LH, FSH, and TSH), and the opiomelanocortin family (ACTH, /i-endorphin, and related peptides). These three families appear to have evolved from three separate ancestral polypeptides homologous members of each family occur in other parts of the body. For example, human placental lactogen (hPL) is somatomammotropic, human chorionic gonadotrophin (hCG) is a glycoprotein hormone, and the brain and gut produce substances related to endorphins (enkephalins and dynorphin). [Pg.737]

Similar sensors have been developed for the determination of human chorionic gonadotrophin (HCG) (Robinson et al., 1985, 1986b) and a-... [Pg.277]

Another mechanism that surfaced was Dr. Livingston s discovery that P. cryptocides could produce a hormone nearly identical to the human hormone named human chorionic gonadotrophin (HCG), called the hormone of life and death. It... [Pg.70]

Tumour markers fall into one of several groups they may be homiones. e.g. human chorionic gonadotrophin (HCG) secreted by choriocarcinoma or enzymes, e.g. prostatic acid phosphatase in prostate carcinoma or tumour antigens. e.g. carcinoembryonic antigen (CEA) in colorectal carcinoma. [Pg.46]

One of the earliest such POC tests developed was the home pregnancy test. It is based on a qualitative immunological antibody assay. It relies on the determination of human chorionic gonadotrophin (hCG) levels in urine, which gives rise to a coloured band if positive. The device is very small and completely disposable. A quality control check is built in where the rest of the urine sample continues along the dipstick and interacts with a pH-sensitive indicator to show that the test has been performed correctly. [Pg.208]

Expression of human trophinin by uterine epithehal cells was narrowly limited to the implantation site (36,38,39). Human chorionic gonadotrophin (hCG) secreted from the blastocyst induced trophinin expression by the maternal epithelia (39) for adhesion (Fig. 2). The beta chain of hCG, or CGp, is unique to primates and is not highly homologous between primates and humans (47,48), providing a molecular basis for mechanisms unique to human embryo implantation (39). [Pg.296]

Studies on the sub-units of human glycoprotein hormones in relation to reproduction have been reviewed. " One volume of a treatise on hormonal proteins and peptides has been devoted to thyroid hormones. The ectopic production of human chorionic gonadotrophin (hCG) and its a- and /J-sub-units has been discussed. ... [Pg.385]

Human chorionic gonadotrophin (hCG) Either Chorulon (Intervet Laboratories Ltd., Cambridge, UK) or hCG (Sigma-Aldrich, St Louis, MO C8554) can be used. Working solution 50IU/mL made np with sterile water or 0.9% (w/v) NaCl. Store frozen at 4°C in 1-mL aliqnots. [Pg.81]

Xenopus females are induced to lay eggs by the injection of500-1000lU human chorionic gonadotrophin (HCG) into their dorsal lymph sacs. This technique is... [Pg.398]

Human Chorionic Gonadotrophin (hCG) Hormone produced by the placenta it helps preserve the uterine lining and its presence is used to confirm pregnancy. [Pg.1610]

Human chorionic gonadotrophin (HCG) is structurally similar to LH and has many of its actions. It is secreted by the placenta and by trophoblastic tumours. [Pg.165]

A test of testicular function based on the fact that human chorionic gonadotrophin (HCG) resembles LH in its actions and stimulates the Leydig cells of the testis to secrete testosterone. It consists of injecting HCG and then measuring plasma testosterone in samples collected over several days. Patients with primary testicular failure fail to respond. [Pg.175]

A simple radioactive assay has been developed to evaluate the combination of subunits from human chorionic gonadotrophin (hCG), thyrotrophin, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). The method is claimed to detect the formation of less than one picomole of the resulting hormone. An homology in the amino-acid sequences has been detected in the B-chain of cholera toxin and the /S-subunits of thyrotrophin, LH, hCG, and FSH, and is thought to represent the site on these proteins that binds to the receptors on membranes. Hybridization studies using the a- and -subunits of thyrotrophin, lutrophin, and CG from different species e.g. sheep, cattle, and humans) demonstrated increases in the a-helix and -sheet contents of the proteins, comparable to those observed in the thyrotrophin subunit assembly. ... [Pg.314]

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