Human cell lines, antiproliferative effect

The cytotoxic effect and antitumor activity of triethyltin lupinyl sulfide hydrochloride have been investigated133. Different patterns of antiproliferative effects have been observed in a panel of human cell lines in vitro. Acute toxicity at doses of 21 and 17.5 mg kg-1 in mice was reported and disappeared progressively at lower concentrations. On this base, the doses of 3.5, 7 and 14 mgkg-1 were selected to assess the antitumor activity in vivo against the P388 leukemic cells xenografted in mice. This compound was able to induce a dose-dependent significant reduction of tumor volume, up to 46%. 

Figure 26.4 Antiproliferative effect of I2 in human cell lines. After the indicated times, aliquots were removed and the cell number was determined by direct counting using trypan blue exclusion. Data are expressed as mean SD (n = 5) p < 0.05 vs. control cells. MCF-7, mammary cancer LNCaP, prostate cancer NIH-3T3, normal fibroblast.

Seeram NP, Adams LS, Hardy ML and Heber D. 2004. Total cranberry extract versus its phytochemical constituents antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem 52(9) 2512-2517. 

Seeram, N. R Adams, L. S. Hardy, M. L. Heber, D. Total Cranberry Extract versus Its Phytochemical Constituents Antiproliferative and Synergistic Effects against Human Tumor Cell Lines.]. Agric. Food Chem. 2004, 52, 2512-2517. 

Rebougas S de O, Grivicich I, dos Santos MS, Rodriguez P, Gomes MD, de Oliveira SQ, da Silva J, Ferraz ABF. Antiproliferative Effect of a Traditional Remedy, Himatan-thus articulatus Bark, on Human Cancer Cell Lines. Journal of Ethnopharmacology 2011 137(1) 926-929. 

Hoosein, N.M., Brattain, D.E., McKnight, M.K., Childress. K.E., Chakrabarty, S. Brattain, M.G. (1988b) Comparison of the antiproliferative effects of transforming growth factor-p, V,V-dimethylformamide and retinoic acid on a human colon carcinoma cell line. Cancer Lett., 40, 219-232... 

Several reports have described the anticancer activity of curcumin in a variety of cancer cell lines. In vitro studies have established the activity for curcumin against breast, gastric, hepatic, pancreatic, colorectal, urinary bladder, kidney, prostate, cervical, ovarian, uterine, lung, oral, thymic, and skin cancers. Besides these cancer types, curcumin has shown in vitro therapeutic efficacy against hematological cancers including leukemia, lymphoma, and multiple myeloma. One of our early studies established that the antiproliferative effect of curcumin in human breast cancer cell lines, including hormone-dependent, hormone-independent,... 

Rhenium tricarbonyl complexes containing substituted cyclopentadi-enyl and bis diphenylphosphine ligands also were investigated as anticancer agents. The antiproliferative effects on breast cancer of complex A shown in Fig. 23 were examined relative to the known active metabolite, 4-hydroxy tamoxifen, and found to have a similar effect [107]. The cytotoxicity of five rhenium tricarbonyl bis-diphenylphosphine complexes B shown in Fig. 23 was examined for 18 different human cancer cell lines. The tests showed that all the complexes were active against specific tumor cell lines, especially a line of breast and uterine cancer [108]. 

The antiproliferative activity of 1,2,3-dithiazoles 168-176 has been tested in vitro on human myeloid leukemia K562 and L1210 murine leukemia cell lines and compared to the antiproliferative effects of the natural product distamycin A. All the imines 168-176 are active at concentration ranging from 3 to 10 pM and they retain antiproliferative activities comparable to those exhibited by distamycin A. 

H9. Hedlund, T. E., Moffatt, K. A., and Miller, G. J., Stable expression of the nuclear vitamin D receptor in the human prostatic carcinoma cell line JCA-1 Evidence that the antiproliferative effects of la, 25-dihydroxy vitamin D3 are mediated through the genomic signalling pathway. Endocrinology 137, 1554-1561 (1996). 

Z5. Zhuang, S. H., and Burnstein, K. L., Antiproliferative effect of la,25-dihidroxyvitamin D3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation. Endocrinology 139, 1197-1207 (1998). 

Z6. Zhuang, S. H., Schwartz, G. G., Cameron, D., and Blumenstein, K. L., Vitamin D receptor content and transcriptional activity do not fully predict antiproliferative effects of vitamin D in human prostate cancer cell lines. Mol. Cell. Endocrinol. 126, 83-90 (1997). 

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