Histopathologic grading

Ostergaard K, Andersen CB, Petersen J et al. (1999) Validity of histopathological grading of articular cartilage from osteoarthritic knee joints. Ann Rheum Dis 58 208-213... 

The histopathologic grading is based upon the Broder s Classification System (I-IV) (Lucia and Miller 1992) grade I - cells well differentiated with keratinization, prominent intercellular bridges, and keratin pearls grade II to III - greater nuclear atypia, increased mitotic activity, and decreased keratin pearls grade IV - marked nuclear pleomorphism, nuclear mitoses, necrosis, lymphatic and perineural invasion, no keratin pearls, and deeply invasive. 

Jonas S, Bechstein WO, Steinmuller T, et al (2001) Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 33 1080-1086 Khan KN, Yatsuhashi H, Yamasaki K, et al (2000) Prospective analysis of risk factors for early intrahepatic recurrence of hepatocellular carcinoma following ethanol injection. J Hepatol 32 269-278 Koda M, Murawaki Y, Mitsuda A, et al (2000) Predictive factors for intrahepatic recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma. Cancer 88 529-537... 

Numerous studies have been conducted in which animals were exposed to 2-hexanone via inhalation. However, the purpose of many of these studies was to assess the potential effects of combined exposure to 2-hexanone and another substance (usually chloroform or methyl ethyl ketone [MEK]). Study design has consequently involved exposure to only one concentration of 2-hexanone as a control exposure. A single high dose of 2-hexanone was used in several other studies in order to elicit and study histopathological changes in the affected nervous tissue. In addition, the grade or purity of the 2-hexanone administered was not stated in many studies, or in some cases, hexanone with purity as low as 70% was used. As a result of these various complications, the usefulness of the available data is limited. 

Patton, K.T., Chen, H.M., Joseph, L., and X.J. Yang, 2005, Decreased annexin I expression in prostatic adenocarcinoma and in high-grade prostatic intraepithelial neoplasia. Histopathology. 47(6) 597-601. 

R5. Raphael, M., Gentilhomme, O., Tulliez, M., Byron, R A., and Diebold, J., Histopathologic features of high-grade non-Hodgkin s lymphomas in acquired immunodeficiency syndrome. The French Study Group of Pathology for Human Immunodeficiency Virus-Associated Tumors. Arch. Pathol. Lab. Med. 115, 15-20 (1991). 

W11. Wotherspoon, A. C., Doglioni, C., and Isaacson, P. G., Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) A multifocal disease. Histopathology 20, 29-34 (1992). 

TABLE 38.17 frequently used grading schemes (severity scores) for histopathology findings... 

Pawade J, Wilkins BS, Wright DH. Low-grade B-cell lymphomas of the splenic marginal zone a clinicopathological and immunohistochemical study of 14 cases. Histopathology. 1995 27(2) 129-137. 

Nzze H, Cogliatti SB, von Schilling C, et al. Monocytoid B-cell lymphoma morphological variants and relationship to low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue. Histopathology. 1991 18(5) 403-414. 

Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 1998 82(7) 1217-1224. 

Perez-Ordonez B, Linkov I, Huvos AG. Polymorphous low-grade adenocarcinoma of minor salivary glands a study of 17 cases with emphasis on cell differentiation. Histopathology. 1998 32(6) 521-529. 

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