Intercellular bridges

Vidulescu C, Clejan S, O Connor KC (2004) Vesicle traffic through intercellular bridges in DU 145 human prostate cancer cells. J. Cell. Mol. Med. 8 388-396. 

Xue F, Cooley L. kelch encodes a component of intercellular bridges in Drosophila egg chambers. Cell 1993 72(5) 681-693. 

The histopathologic grading is based upon the Broder s Classification System (I-IV) (Lucia and Miller 1992) grade I - cells well differentiated with keratinization, prominent intercellular bridges, and keratin pearls grade II to III - greater nuclear atypia, increased mitotic activity, and decreased keratin pearls grade IV - marked nuclear pleomorphism, nuclear mitoses, necrosis, lymphatic and perineural invasion, no keratin pearls, and deeply invasive. 

Robinson D.N. and Cooley L. 1996. Stable intercellular bridges in development The cytoskeleton Uning the tunnel. Trends Cell Biol. 6 474- 79. 

Figure 6.15 Schematic diagram of a portion of the epithelium covering above a lymphatic nodule in a Peyer s patch (mouse). Attenuated M cells (M) extend as membranelike cytoplasmic bridges between the absorptive columnar epithelial cells present on either side (C). Beneath the M cell lies a small nest of intraepithelial lymphocytes (L) together with a central macrophage (Mac). The M cell provides a thin membrane-like barrier between the lumen above and the lymphocytes in the intercellular space below. This M cell has taken up the macromolecules and particulate matter that reach it and macrophages (Mac) may ingest them. Modified from D.H. Cormack. Lymphatic tissue and the immune system. D.H.Cormack (ed.) (1987) Ham s Histology, J.B. Lippincott Company, Philadelphia, pp. 234-263...

Figure 7.9 Intercellular and subcellular trafficking in alkaloid biosynthesis. A. Tropane alkaloid biosynthesis in Hyoscyamus muticus. B. Terpenoid indole alkaloid biosynthesis in Catharanthus roseus. C. Trafficking of the berberine bridge enzyme in Papaver somniferum cell cultures.

The intercellular lipids present the only single continuous region in the stratum corneum. The stratum corneum can be described as a brick (corneocytes) and mortar (intercellular lipids) structure [1,2]. The epidermal cells are held together primarily by highly convoluted interlocking bridges of desmosomes, tonofibrils (intercellular anchors) and interstitial lipids, which are responsible for the unique integrity of the skin. 

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