High-field asymmetric waveform ion mobility mass

McCooeye, M., and Mester, Z. (2006). Comparison of flow injection analysis electrospray mass spectrometry and tandem mass spectrometry and electrospray high-field asymmetric waveform ion mobility mass spectrometry and tandem mass spectrometry for the determination of underivatized amino acids. Rapid Commun. Mass Spectrom. 20 1801-1808. 

R. Guevremont and R. W. Purves, High field asymmetric waveform ion mobility-mass spectrometry an investigation of leucine enkephalin ions by electrospray ionization, 7. Am. Soc. Mass Spectrom. 10, 492-501 (1999). 

Today, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are considered the standard ionization techniques for LC-MS/MS due to their predominant advantages in quantitative analysis of drug molecules in various sample matrices with high sensitivity, selectivity, reliability, robustness, and ease of operation. Other techniques, for example, atmospheric pressure photoionization (APPI), electron capture atmospheric pressure chemical ionization (EC-APCI), and high-field asymmetric waveform ion mobility mass spectrometry (FAIMS) serve as complements to the established ESI and/or APCI technical platforms whenever necessary for an enhanced sensitivity and/or selectivity of a bioanalytical assay [4,5]. 

Xgg were achieved with an analysis time of 30 min [9]. More recently, Kolakowski et al. 128] demonstrated the use of atmospheric pressure ionization-high field asymmetric waveform ion mobility mass spectrometry for the analysis of nerve agent degradation products in food samples. 

R. Guevremont. High-Field Asymmetric Waveform Ion Mobility Spectrometry A New Tool for Mass Spectrometry. J. Chromatogr., A1058(2004) 3-19. 

Li J, Purves RW, Richards JC. 2004a. Coupling capillary electrophoresis and high-field asymmetric waveform ion mobility spectrometry mass spectrometry for the analysis of complex lipopolysaccharides. Anal Chem 76 4676. 

Guevremont, R. High-field asymmetric waveform ion mobility spectrometry a new tool for mass spectrometry. J Chromatogr A 2004, 1058, 3-19. 

Hatsis, P., Brockman, A. H., and Wu, J. T. (2007). Evaluation of high-field asymmetric waveform ion mobility spectrometry coupled to nanoelectrospray ionization for bioanalysis in dmg discovery. Rapid Commun. Mass Spectrom. 21 2295-2300. 

McCooeye, M., Ding, L., Gardner, G. J., Fraser, C. A., Lam, J., Sturgeon, R. E., and Mester, Z. (2003). Separation and quantitation of the stereoisomers of ephedra alkaloids in natural health products using flow injection-electrospray ionization-high field asymmetric waveform ion mobility spectrometry-mass spectrometry. Anal. Chem. 75 2538-2542. 

McCooeye, M. A., Ells, B., Barnett, D. A., Purves, R. W., and Guevremont, R. (2001). Quantitation of morphine and codeine in human urine using high-field asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection. J. Anal. Toxicol. 25 81-87. 

Purves, R. W., and Guevremont, R. (1999). Electrospray ionization high-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Anal. Chem. 71 2346-2357. 

S. McSheehy, Z. Mester, Arsenic speciation in marine certified reference materials. Part 1. Identification of water-soluble arsenic species using multidimensional liquid chromatography combined with inductively coupled plasma, electrospray and electrospray high-field asymmetric waveform ion mobility spectrometry with mass spectro-metric detection, J. Anal. Atom. Spectrom., 19 (2004), 373-380. 

Figure 8.4 Comparison of mass spectra of haloacetic acids in a 500-fold diluted EPA 552.1 standard in electrospray MS acquired (a) without, and (b) with the use of high-field asymmetric waveform ion mobility spectrometry (FAIMS) (Reproduced from [67] with permission, 1999, American Chemical Society).

While the majority of separahons are carried out with chromatographic processes, recent advances in the design of ion-mobility instruments provide a crude means to frachonate samples that enter the mass spectrometer based on molecular size and three-dimensional (3D) shape, rather than mass to charge or polarity. The use of high-field asymmetric-waveform ion-mobility... 

Purves, R.W. Guevremont, R. Electrospray Ionization High-Field Asymmetric Waveform Ion Mobility Spectrometry-Mass Spectrometry, Anal. Chem. 71, 2346-2357 (1999). 

McCooeye, M.A. Mester, Z. Ells, B. Barnett, D.A. Purves, R.W. Guevremont, R. Quantitation of Amphetamine, Methamphetamine, and Their Methylene-dioxy Derivatives in Urine by Solid-Phase Microextraction Coupled with Electrospray lonization-High-Field Asymmetric Waveform Ion Mobility Spectrometry-Mass Spectrometry, Anal. Chem. 74, 3071-3075 (2002). 

Kapron, J.T. et al., Removal of metabolite interference during liquid chromatography/ tandem mass spectrometry using high-field asymmetric waveform ion mobility spectrometry, Rapid Commun. Mass Spectrom., 19(14), 1979, 2005. 

Wu, S.T., Xia, Y.Q., and Jemal, M., High-field asymmetric waveform ion mobility spectrometry coupled with liquid chromatography/electro spray ionization tandem mass spectrometry (LC/ESI-FAIMS-MS/MS) multi-component bioanalytical method development, performance evaluation and demonstration of the constancy of the compensation voltage with change of mobile phase composition or flow rate, Rapid Commun. Mass Spectrom., 21(22), 3667, 2007. 

Brown, L.J. Toutoungi, D.E. Devenport, N.A. Reynolds, J.C. Kaur-Atwal, G. Boyle, R, Creaser CS., Miniaturized ultra high field asymmetric waveform ion mobility spectrometry combined with mass spectrometry for peptide analysis. Anal. Chem. 2010, 82(23), 9827-9834. 

Purves, R.W. Guevremont, R., Electrospray ionization high-field asymmetric waveform ion mobility spectrometry-mass spectrometry, A a/. Chem. 1999, 71, 2346-2357. Viehland, L.A. Mason, E.A., Transport properties of gaseous ion over a wide energy range. At. Data Nucl. Data Tables 1995, 60, 37-95. 

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