Natural health products

Fitzpatrick, K.C., Regulatory issues related to functional foods and natural health products in Canada Possible implications for manufacturers of conjugated linoleic acid, Am J Clin Nutr, 79, 1217S, 2004. 

Foster, B.C., Amason, J.T., and Briggs, C J., Natural health products and drug disposition, Annu Rev Pharmacol Toxicol, 45, 203, 2005. 

NHPD Natural Health Products Directorate (Canada)... 

Herb-drug interactions are of growing concern due to the increased use and awareness of natural health products. They generally arise when natural health products inhibit CYP enzymes, altering the rate of metabolism for other drugs in the system. It is important to note, however, that interactions may also arise when... 

Health Canada - Natural Health Products Directorate. Online. Available HTTP (accessed 9 April 2003). 

Natural Health Products Directorate works to ensure that all Canadians have ready access to natural health products that are safe, effective, and of high quality, while respecting freedom of choice and philosophical and cultural diversity . 

Foster BC, Vandenhoek S, Hanna J, et al. Effects of natural health products on cytochrome P-450 drug metabolism. Phytomedicine 2003 10 334-342. 

McCooeye, M., Ding, L., Gardner, G. J., Fraser, C. A., Lam, J., Sturgeon, R. E., and Mester, Z. (2003). Separation and quantitation of the stereoisomers of ephedra alkaloids in natural health products using flow injection-electrospray ionization-high field asymmetric waveform ion mobility spectrometry-mass spectrometry. Anal. Chem. 75 2538-2542. 

The HPFB evaluates and monitors the safety, efficacy, and quality of thousands of human and veterinary drugs, medical devices, natural health products, and other therapeutic products available to Canadians, as well as the safety and quality of food in Canada. 

Natural Health Products http //www.hc-sc.gc.ca/hpfb-dgpsa/nhpd-dpsn/... 

Echinacea is sold as a dietary supplement in the United States and as a natural health product in Canada. However, Health Canada does support the use of Echinacea in food products thus functional foods could be developed for the Canadian market. In the United States and Canada, there are no restrictions on the species/varieties used in products. In Germany and many European countries, Echinacea products are sold as drugs in pharmacies (Bauer, 2000). In addition, not all products are approved for use in all countries. For example, E. purpurea aerial parts and E. pallida roots are approved in Germany whereas E. angustifolia and E. purpurea roots are not (Blumenthal, 1998). 

Canada currently has a system of harsher regulations of natural health products, that country s classification for dietary supplements. In 2004, the government formally began regulating natural health products under the Natural Health Products Directorate (NHPD). The NHPD maintains certain safety and quality levels that manufacturers of dietary supplements must meet. Many in the United States would like the FDA to adopt a similar practice. 

Native Americans 18 Natural Health Products Directorate 112... 

The National Health Products Directorate and Health Products and Food Branch of Health Canada believe these new policies, when fully enacted, will serve the consumer well. By meeting quality and safety standards based on good manufacturing practices and only allowing health claims supported by appropriate levels of evidence to accompany natural health products, the basis for rational use has been established (Health Canada, 2004). 

Health Canada 2004. Natural Health Products Directorate (NHPD) Progress on the 53 Recommendations of the Standing Committee on Health, pp. 1-17. Health Canada, Ottawa. 

As noted in nnmerons market reports in North America and elsewhere, there is a bright future for the appropriate development, marketing, and use of medicinal plants and related products in foods, dietary supplements, natural health products (the regulatory term in Canada), over-the-coimter and prescription drugs, and cosmetics. This book provides an excellent opportunity to delve into the current and fiitine contributions that African plants can and will continue to make to this expanded worldwide market. 

Ramji, D., Sang, S., Liu, Y., Rosen, R. T., Ghai, G., Ho, C. T., Yang, C. S., and Huang, M. T. 2005. Effect of black tea theaflavins and related benzotropolone derivatives on 12-0-tetradecanoylphorbol-13-acetate-induced mouse ear inflammation and inflammatory mediators. In Phenolic compounds in foods and natural health products, ed. F. Shahidi and C. T. Ho, 242-53. Washington, DC American Chemical Society. 

F. Shahidi, C. T. Ho, Compounds in Foods and Natural Health Products,... 

Mills E, Wu P, Johnston BC, GaUieano K, Clarke M, Guyatt G. Natural health product-drug interactions a systematic review of clinical trials. Ther Drug Monit 2005 27 549-557. 

Shahidi, F. and Ho, C.-T., Phenolics in food and natural health products An overview, in Phenolic Compounds in Foods and Natural Products, Shahidi, F. and Ho, C.-T., Eds., ACS Symposium Series 909, American Chemical Society, Washington, DC, 2005, pp. 1—8. 

Griffiths J, Jordan S, Pilon S. Natural health products and adverse reactions. Can Adverse React News (2004) 14, 2-3. 

Health Canada s Natural Health Products Directorate (NHPD) has concluded that daily use by healthy adults of p-synephrine at up to 50 mg, or up to 40 mg in combination with up to 320 mg of caffeine, would generally result in a Type III risk classification. This classification is defined to mean that such use "is not likely to cause any adverse health consequences." On the other hand, NHPD determined that products that contain p-synephrine but lack certain cautionary statements, identified as "contraindicated in children, pregnancy, and breast-feeding, do not use if you are taking blood pressure medications (either hypertensives or antihypertensives), thyroid medications, sympathomimetics, or monoamine oxidase inhibitors," would be subject to a Type II risk classification (meaning "the use of, or exposure to, such a product may cause temporary adverse hedth consequences or where the probability of serious adverse health consequences is remote") (Maries 2011). 

Maries, R. 2011. Synephrine, octopamine and caffeine Health Risk Assessment (HSR) Report. Flealth Canada. Natural Health Products Directorate. 

Anon. (Ipsos-Reid). 2005. Baseline Natural Health Products Survey Among Consumers Final Report. Health Canada, Natural Health Products Directorate. 

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