Hepatitis morphology

In a two-year study (United States National Toxicology Program, 1989 Kari et al., 1992), dose-dependent hepatic morphological changes (anisokaryosis, elevated frequency of multinucleated cells) were observed in male mice. In a long-term feeding study (0.8% in the diet) (Shibata et al., 1991), hepatic centrilobular hypertrophy was observed in males and forestomach hyperplasia in both males and females, while no non-neoplastic changes in the kidney were reported. 

Exposure of male Fischer 344 rats to ptzra-xylene (0-1600 ppm [0-6940 mg/m- ], 6 h per day for one or three days) had negligible effect on hepatic morphology and serum activities of alanine or aspartate aminotransferases, lactate dehydrogenase, ornithine carbamyl transferase, alkaline phosphatase or serum bilirubin concentration (Simmons et al., 1991). Liver size was increased and its cytochrome P450 content was elevated. 

Dodd, G.D.I., Baron, R.L., Oliver, J.H.I. End-stage primary sclerosing cholangitis CT findings of hepatic morphology in 36 patients. Radiology 1999 211 357-362... 

Ito, K., Mitchell, D.G. Hepatic morphologic changes in cirrhosis MR imaging findings. Abdom. Imag. 2000 25 456-461... 

Arddi, J.M., Moore, G.W., Hutchins, G.M. Hepatic morphology in cardiac dysfunction. A clinicopathologic study of 1000 subjects at autopsy. Amer. J. Pathol. 1981 104 159-166... 

Interaction Between Water Pollutants Quantitative Electron Microscopy of Hepatic Morphological Changes Induced by 1,2-Dichloroethane (DCE) and 1,1-Dichloroethylene (VDC)... 

Hepatitis is acute or chronic inflammation of the liver, which is frequently caused by infection with hepato-tropic viruses. Several forms of viral hepatitis (A, B, C, D, E) are known, which result from infection with viruses belonging to separate virus families, differing in their genomic organization, replication strategies, morphology and modes of transmission. 

The serum from patients with clinical symptoms of hepatitis B commonly contain three distinct structures that possess HBsAg (section 3.8.5 above). The effects of different concentrations of various disinfectants on the structure of Dane particles have been studied, but it is unlikely that morphological changes can be related to virucidal activity. 

Benitz KF, Roth RN, Coulston F. 1977. Morphologic characteristics of hepatic nodules induced by mirex and dieldrin in mice. Toxicol Appl Pharmacol 41 (I) 154-155. 

The presence of protein-hydropic degeneration (Fig. 13a), punctuate infiltration and necrosis, reaction of hepatic macrophages (Fig. 13b), nuclear polimorphysm (Fig. 13c), inflammatory infiltration of portal tracts and perivenular infiltration (Fig. 13d) were considered in the assessment of morphological alterations in the liver of the mice. 

Lewis J.A., M.J. Clemens, and J.R. Tata (1976). Morphological and biochemical changes in the hepatic endoplasmic reticulum and golgi apparatus of male Xenopus laevis after induction of egg yolk protein s3mthesis by oestradiol-17 3. Molecular and Cellular Endocrinology 4 311-329. 

Many studies have examined the hepatic biochemical and morphological effects of di(2-ethylhexyl) phthalate (reviewed in Huber et al., 1996). Such effects in rodents include peroxisome proliferation, which is characterized by increases in the number of... 

Mikalsen, S., Holen, I. Sarmer, T. (1990) Morphological transformation and catalase activity of Syrian hamster embryo cells treated with hepatic peroxisome proliferators, TPA and nickel sulphate. Cell Biol. Toxicol., 6, 1-13... 

A number of studies have examined the hepatic biochemical and morphological changes in rats produced by coumarin administration for periods ranging from one week to two years (reviewed in Lake, 1999). Coumarin administration results in increased liver weight and in a variety of morphological changes in treated rats that are dependent... 

In rats burned once with 29 or 100 mg/kg/day white phosphoms, an increase in ALT levels, necrosis, ballooning degeneration of hepatocytes, and microthrombi in the portal veins have been observed (Ben-Hur and Appelbaum 1973 Ben-Hur et al. 1972). In rabbits burned by white phosphoms (dose not reported), serum calcium and phosphoms levels were normal, and no morphological damage was observed (Bowen et al. 1971). No longer-term human and animal studies examining hepatic effects were found. 

The impetus for the developmental studies came not from embryology but from clinical observations on the postnatal organism, on metabolic problems frequently seen in newborn children. They occurred in the absence of genetic or morphological abnormalities, were often transient, indicated defects in hepatic functions, and had a higher incidence in premature than in term infants. For these reasons, Dawkins(4) suggested that several important hepatic enzymes are acquired only shortly before or after term, so that the newborn is not immediately ready to take over functions which, like detoxifixations, had been carried out by the maternal liver. 

Rat 28 d (Fischer- 344) (F) Hepatic 705 (>53% increase in relative liver weights morphological and biochemical evidence of peroxisome proliferation) Hodgson 1987... 

Rat (albino) 9 mo (F) Hepatic 50 (increased liver weight, morphological changes in bile ducts, lipid filled lysosomes, glycogen depletion, induction of peroxisomal enzymes and cytochrome P-450 system) Mitchell et al. 1985b... 

Rat (Sprague- Dawley) 102 wk (F) Hepatic 140 (morphological and enzymatic evidence of moderate peroxisome proliferation) Ganning et al. 1991... 

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