Carbamyl transferase

The liver appeared to be a target organ for hexachloroethane following oral administration. When one dose of 500 mg/kg was administered in an olive oil aqueous emulsion to male sheep, the levels of glutamate dehydrogenase, sorbitol dehydrogenase, ornithine carbamyl transferase, and aspartate aminotransferase in serum increased in the 2-day period after compound administration and then normalized (Fowler 1969b). Hexachloroethane had no effect on bromsulphthalein uptake from the blood by liver cells, but the transfer of this dye to bile was reduced in sheep exposed to doses of 500-1,000 mg/kg/day. 

Exposure of male Fischer 344 rats to ptzra-xylene (0-1600 ppm [0-6940 mg/m- ], 6 h per day for one or three days) had negligible effect on hepatic morphology and serum activities of alanine or aspartate aminotransferases, lactate dehydrogenase, ornithine carbamyl transferase, alkaline phosphatase or serum bilirubin concentration (Simmons et al., 1991). Liver size was increased and its cytochrome P450 content was elevated. 

Sato et al. [4] Ornithine Prawns Ornithine carbamyl transferase and pyruvate oxidase in a reactor Oxygen electrode -... 

Shin et al. [88] Ornithine Kuruma prawn Ornithine carbamyl transferase, nucleoside phosphorylase and xanthine oxidase/in membranes prepared from cellulose triacetate, glutaraldehyde and 1,8-diamino-4-am i nomethyl octane Oxygen electrode ... 

Hyperammonemia occurs in biotin deficiency and the functional deficiency associated with lack of holocarboxylase synthetase (Section 11.2.2.1) and bio-tinidase (Section 11.2.3.1). In deficient rats, the activity of ornithine carbamyl-transferase is two - thirds of that in control animals, as a result of decreased gene expression, although the activities of other urea cycle enzymes are unaffected (Maeda etal., 1996). 

DiVincenzo GD, Krasavage WJ. 1974. Serum ornithine carbamyl transferase as a liver response test for exposure. Am Ind Hyg Assoc J 35 21-29. 

The biomolecular modes of action of ornithine have been the subject of several experimental investigations. Ornithine activates the enzymes carbamylphosphate synthetase and ornithine carbamyl transferase, which are necessary for the liver-specific process of urea synthesis (133,139) this occurs mainly in the periportal hepa-tocytes (= definitive ammonia detoxification). Glutamine synthesis (binding of ammonia to glutamate) takes place predominantly in the perivenous hepatocytes (= transitory ammonia detoxification). Large amounts of glutamate are necessary for this. Aspartate, ornithine... 

Kulhanek, V., and Vojtiskova, V., On the determination of ornithine carbamyl-transferase activity. Clin. Chitn. Acta 9, 95-96 (1964). 

This enzyme, also called ornithine carbamyl transferase, catalyzes the reaction... 

Bondy, G. S., C. L. Armstrong, I. H. Curran, M. G. Barker, and R. Mehta. 2000. Retrospective evaluation of serum ornithine carbamyl transferase as an index of hepatotoxicity in toxicological studies with rats. Toxicology Letters 114 163-171. 

Peltenburg, H. G., M. A. Janssen, P. B. Soeters, J. G. Elendrig, and W. T. Hermans. 1991. Measurement of ornithine carbamyl transferase (OCT) in plasma by means of enzymatic determination of ammonia. Clinica ChimicaActa 203 395 02. 

Lohss, E., C. Eederhen, and W. Kraft. 1988. Die ornithin-carbamyl-transferase (OCT) 5 -Nucleotidase (5 -ND) und Leucinarylamidase (LAP) als diagnostika bei leber-krankheiten des hundes. Journal of Veterinary Medicine A 35 81-91. 

Z Ornithine carbamyl transferase, iron responsive element binding protein... 

Ml Macleod, P., Mackenzie, S. and Scriver, C. R. Partial ornithine carbamyl transferase deficiency, an inborn error of the urea cycle presenting as orotic aciduria in a male infant. Can. Med. Assoc. J., 107, 405-408 (1972)... 

Ornithine carbamyl transferase catalyzes the irreversible transfer of one molecule of carbamyl phosphate on the terminal amino group of a molecule of ornithine to yield citrulline and Pi. 

Liver biopsies have revealed three different groups of patients those with low ornithine carbamyl transferase levels and hyperammonemia, those with low arginosuccinic acid synthetase and citrullinemia, and those with low argininosuccininase and argininosuc-cinicaciduria [62]. 

Assessment of synthetic function serum ALAT, ASAT, ornithine carbamyl transferase, albumin globulin, coagulation profile, prothrombin time, partial thromboplastin time, radioactive amino acids, electrophoresis techniques for serum proteins Assessment of excretion function gamma-glutyml transferase, LDH, bilirubin, alkaline phosphatase... 

A urea cycle enzyme found mainly in the liver and kidney. High serum levels are found in conditions where there is hepatocellular damage such as hepatitis. A congenital deflciency of the enzyme has also been described (ornithine carbamyl transferase deficiency). 

Serum liver enzymes are elevated, including aspartate transaminase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (AP), ornithine carbamyl transferase, and isocitric dehydrogenase. 

I. Carbamyl Phosphate-Aspartate Transcarbamylase (Aspartate Carbamyl Transferase)... 

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