Health hazard, defining

Activated carbon generally presents no particular health hazard as defined by NIOSH (62). However, it is a nuisance and mild irritant with respect to inhalation, skin contact, eye exposure, and ingestion. On the other hand, special consideration must be given to the handling of spent carbon that may contain a concentration of toxic compounds. 

Are prevention measures being defined and used to control all identified potential health hazards adequately ... 

SUBSTANCE HAZARDOUS TO HEALTH As defined in Regulation 2 of tlie Control of Substances Hazardous to Health Regulations 1999,... 

The first major objective for the inherent safety review is the development of a good understanding of the hazards involved in the process. Early understanding of these hazards provides time for the development team to implement recommendations of the inherent safety effort. Hazards associated with flammability, pressure, and temperature are relatively easy to identify. Reactive chemistry hazards are not. They are frequently difficult to identify and understand in the lab and pilot plant. Special calorimetry equipment and expertise are often necessary to fully characterize the hazards of runaway reactions and decompositions. Similarly, industrial hygiene and toxicology expertise is desirable to help define and understand health hazards associated with the chemicals employed. 

Permit space As defined by OSHA, a confined space that contains a hazardous atmosphere, a material that could engulf an occupant, a configuration that could trap an occupant, or any other recognized safety or health hazard. 

Since 1970 tlie field of healtli risk assessment Itas received widespread attention witliin both tlie scientific and regulatoiy committees. It has also attracted tlie attention of the public. Properly conducted risk assessments have received fairly broad acceptance, in part because they put into perspective the terms to. ic, Itazard, and risk. Toxicity is an inlierent property of all substances. It states tliat all chemical and physical agents can produce adverse healtli effects at some dose or under specific exposure conditions. In contrast, exposure to a chemical tliat lias tlie capacity to produce a particular type of adverse effect, represents a health hazard. Risk, however, is tlie probability or likelihood tliat an adverse outcome will occur in a person or a group tliat is exposed to a particular concentration or dose of the hazardous agent. Tlierefore, risk can be generally a function of exposure and dose. Consequently, healtli risk assessment is defined as tlie process or procedure used to estimate tlie likelihood that... 

Hazard identification is defined as tlie process of determining whetlier human exposure to an agent could cause an increase in the incidence of a health condition (cancer, birtli defect, etc.) or whetlier exposure to nonliumans, such as fish, birds, and otlier fonns of wildlife, could cause adverse effects. Hazard identification cliaracterizes tlie liazard in terms of tlie agent and dose of the agent. Since tliere are few hazardous chemicals or hazardous agents for wliich definitive exposure data in humans exists, tlie identification of health hazards is often characterized by the effects of health hazards on laboratory test animals or other test systems. ... 

Chemical Exposure Index (CEI) (Chemical Exposure Index, 1994 Mannan, 2005, pp. 8/22-8/26.) The CEI provides a method of rating the relative potential of acute health hazard to people from possible chemical release incidents. It may be used for prioritizing initial process hazard analysis and establishing the degree of further analysis needed. The CEI also may be used as part of the site review process. The system provides a method of ranking one risk relative to another. It is not intended to define a particular containment system as safe or unsafe, but provides a way of comparing toxic hazards. It deals with acute, not chronic, releases. Flammability and explosion hazards are not included in this index. To develop a CEI, information needs include... 

This information sheet from the Health and Safety Executive summaries the health hazards that can arise from exposure to styrene. It provides practical advance to FRP manufacturers on how to assess and control styrene levels in the workplace and how these control measures should be monitored and maintained in accordance with the Control of Substances Hazardous to Health Regulations 2002. The document applies mainly to contact moulding processes, and aims to define what level of control is currently recognised as being reasonably practicable. EUROPEAN COMMUNITY EUROPEAN UNION UK WESTERN EUROPE... 

RW II is an effect-related value based on current toxicological and epidemiological knowledge of a substance s effect threshold which takes uncertainty factors into account. It represents the concentration of a substance which, if reached or exceeded, requires immediate action as this concentration could pose a health hazard, especially for sensitive people who reside in these rooms over long periods of time. Depending on the mode of action, guide value II may be defined either as a short-term value (RW II K) or a long-term value (RW II L). 

The impurity profile is insufficiently defined to assess a potential health hazard... 

CMC information It should contain sufficient detail to assure identification, quality, purity, and strength of the investigational drug. It should include stability data of duration appropriate to the length of the proposed study. FDA concerns to be addressed focus on products made with unknown or impure components, products with chemical structures known to be of likely high toxicity, products known to be chemically unstable, and products with an impurity profile indicative of a health hazard or insufficiently defined to assess potential health hazard, or poorly characterized master or working cell bank. 

The Occupational Safety and Health Act (PL 91-596, OSHA) protects workers against safety and health hazards in the occupational environment, and requires that all employees be provided a safe and healthy work environment. Can students be defined as "workers" or "employees" according to OSHA ... 

Reasons for concern may include (a) a product made with unknown or impure components, (b) a product possessing chemical structures of known or highly likely toxicity, (c) a product that cannot remain chemically stable throughout the testing program proposed, (d) a product with an impurity profile indicative of a potential health hazard or an impurity profile insufficiently defined to assess a potential health hazard, or (e) a poorly characterized master or working cell bank. 

The TL and MAK values should be used as guides in the control of health hazards. They are not constants that can be used to draw fine fines between safe and dangerous concentrations. Nor is it possible to calculate the TL or MAK values of solvent mixtures from the data in Table A-13, because antagonistic action or potentiation may occur with some combinations. It should be noted that occupational exposure limits such as the TL and MAK values are not intended for use as a comparative measure of one solvent against another. The values set airborne concentration limits on chemical exposure, but do not describe the ease with which that airborne limit is achieved. In addition, the vapour pressure of the solvent must also be considered. The lower the vapour pressure, the lower the airborne concentration. In order to better compare the safety of volatile compounds such as organic solvents, the use of the vapour hazard ratio ( VHR) has been recommended as a feasible measure [175], The vapour hazard ratio is defined as the quotient of the saturation concentration of a solvent (in mg/m at a given temperature and pressure) and its occupational exposure limit (in mg/m e.g. TL or MAK values), according to ... 

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