Hansenula

Hansenula anomala Pichia miso Pichia farinosa Candida polymorpha Candida tropicalis Torulopsis versatilis... 

Kido T, K Sida, K Asada (1978b) Properties of 2-nitropropane dioxygenase of Hansenula mrakii. J Biol Chem 253 226-232. 

Traditional and well-established yeast species are Saccharomyces cerevisiae, Hansenula polymorpha, Klyveromyces lactis, Pichia pastoris and Schizosaccharomyces pombe. With every year that passes they are increasingly being used in industrial and pharmaceutical enzyme production on a large scale. Many further yeasts present interesting features (e.g. Arxula adeninivorans and Yarrowia lipolytica), but are not that widely used. 

PI. polymorpha [80] is generally referred to as safe and was widely used for pharma-protein production (cytokines, vaccines, coagulation factors) [80]. The genome sequence is known and DNA chip technologies have been established. Hansenula was developed to an expression platform which was implemented for the production of recombinant vaccines. 

Steinborn, G., Boer, E., Scholz, A. et al. (2006) Application of a wide-range yeast vector (CoMed) system to recombinant protein production in dimorphic Arxula adeninivorans, methylotrophic Hansenula polymorpha and other yeasts. Microbial Cell Factories, 5, 33. 

Gellissen, G., Kunze, G., Gaillardin, C. et al. (2005) New yeast expression platforms based on methylotrophic Hansenula polymorpha and Pichia pastoris and on dimorphic Arxula adeninivorans and Yarrowia lipolytica - a comparison. FEMS Yeast Research, 5 (11), 1079-1096. 

The second patent describes the use of a microbial mixed culture (Hansenula sydowiorum, Hansenula ciferrii, Hansenula lynferdii, and/or Cryptococcus albidus) in coal desulfurization [160], In this process, the raw mined coal is ground to a particle size smaller than 200 mesh forming a slurry with water, at a solids concentration of less than 40wt%. The bacterial cultures are then inoculated into the feedstock slurry. An incubation step is carried out at a temperature near 25°C and at a pH close to neutral. The highest removal achieved was in the range of 46% S removal. 

The yeast Hansenula polymorpha serves as the production system for a recombinant hepatitis B vaccine (Berna Biotech AG [8] and yeast is also used to produce granulocyte-macrophage colony stimulating factor (GM-CSF), marketed as Leukine by Schering AG. 

Handylab, 26 976 Hanford N reactor, 17 572-573 Hanford production reactors, 17 570 Hanksite, 5 785t Hansa yellows, 14 317 Hansch equation, 10 329 Hansenula polymorpha, 12 479 Hantaviruses, 3 137 Hantzsch pyridine synthesis, 16 550 Hantzsch-Widman nomenclature system, 17 399... 

Fig. 15.—13C-N.m.r. Spectrm of Linear a-D-Mannopyranan from Hansenula capsu-lata. (Solvent, D20 temperature, 70° chemical shifts expressed as 8C, relative to external tetramethylsilane.)...

In addition to the coupled-signal method just described, phosphorylated carbon signals can be detected by use of praseodymium chloride, which displaces a- and /8-carbon resonances of a,/8-D-mannose 6-phosphate and a-D-mannosyl phosphate downfield, with little effect on other resonances. Europium chloride has analogous properties, except that the displacements are upfield. With certain polysaccharides, such as the O-phosphonomannan of Hansenula capsulata (29), the sig-... 

Hammett s-constants, of astatophenols, 31 66 Hansenula anomala, flavocytochrome bj from, 36 260-261... 

Ihn GS, Park KH, Pek UH, Moo Jeong (1992) Microbial sensor of biochemical oxygen demand using Hansenula anomala. Bull Korean Chem Soc 13 145-148 Sohn M-J, Hong D (1993) Comprehension of the response time in a microbial BOD sensor (II). Bull Korean Chem Soc 14 666-668... 

---