Haematological malignancy

Candida albicans Haematologic malignancies with iron overload I.2a II... 

Arts, J., Angibaud, P., Marien, A., Floren, W, Janssens, B., King, P. et al. (2007) R306465 is a novel potent inhibitor of class I HDACs with broad-spectrum antitumoral activity against solid and haematological malignancies. British Journal of Cancer, 97, 1344—1353. 

Al. Adam, R, CSF cytological findings in haematological malignancies. Czech Slav. Neurol. Neurosurg. 57(6), 277-278 (1990). 

Patients with leukemia often suffer from infections of the upper respiratory tract before the diagnosis of their haematologic malignancy is made. Chemotherapy for malignancy causes toxic stomatitis and superinfection with yeasts may follow. In patients with diabetes mellitus, malignant otitis externa and fungal sinusitis (mucormycosis) can be life-threatening. 

Increased numbers, particularly of neutrophils, characterize many inflammatory states. This is a physiologically appropriate response and no treatment is necessary. Conversely, there may be elevations due to underlying haematological malignancies or seen in acute or chronic leukaemia. Once such a suspicion arises the patient should immediately be referred to a clinical haematologist. Specialist investigation and management falls outside the ambit of this chapter. 

Ribatti D, Vacca A Therapeutic renaissance of thalidomide in the treatment of haematological malignancies. Leukemia 2005 19 1525. [PMID 15973447]... 

Levene AP, Morgan GJ, Davies FE. The use of genetic microarray analysis to classify and predict prognosis in haematological malignancies. Clin Lab Haematol 2003 25 209-220. 

Takubo T, Kumura T, Nakamae H, Aoyama Y, Koh KR, Ohta K, et al. Urinary trypsin inhibitor levels in the urine of patients with haematological malignancies. Haematologia (Budap) 2001 31 267-272. 

Methotrexate is used widely as a DMARD for rheumatoid arthritis, psoriatic arthritis, and for its steroid-sparing effects in many other conditions, especially if azathioprine is not tolerated. In high dose, with folinic acid rescue, methotrexate is used to treat solid and haematological malignancies (see p. 612). Low dose methotrexate slows the progression of rheumatoid arthritis. The evidence for a true disease-modifying effect on psoriatic arthritis is less definite, but methotrexate is often preferred to other DMARDs for its beneficial effect on the skin lesions. 

Stewart A K, Schuh A C 2000 White cells impct of unerstanding the molecular basis of haematological malignant disorders on clinical practice. Lancet 355 1447-1453... 

Eiff, von, M., Essink, M., Roos, N., Hiddemann, W., Buchner, T., van de Loo, J. Hepatosplenic candidiasis, a late manifestation of Candida septicaemia in neutropenic patients with haematologic malignancies. Blut 1990 60 242-248... 

Romano S, Fdez de Gatta MM, Calvo MV, Caballero D, Dominguez-Gil A, Lanao JM. Population pharmacokinetics of amikacin in patients with haematological malignancies. J Antimicrob Chemother 1999 44(2) 235 2. 

Martino R, Subira M, Sureda A, Sierra J. Amphotericin B lipid complex at 3 mg/kg/day for treatment of invasive fungal infections in adults with haematological malignancies. J Antimicrob Chemother 1999 44(4) 569-72. 

Buckley MM, Lamb HM. Oral idarubicin. A review of its pharmacological properties and clinical efficacy in the treatment of haematological malignancies and advanced breast cancer. Drugs Aging 1997 ll(l) 61-86. 

Jensen HE, Salonen J, Ekfors TO. The use of immunohisto-chemistty to improve sensitivity and specificity in the diagnosis of systemic mycoses in patients with haematological malignancies. / Patbo/. 1997 181 100-105. 

Famotidine 40 mg was found to reduce the serum levels of a 200-mg dose of itraconazole by about 50% in 12 healthy subjects. Famotidine 20 mg twice daily was given with itraconazole 200 mg daily for 10 days to 16 patients undergoing chemotherapy for haematological malignancies. The minimum plasma levels of itraconazole were reduced by about 39%, and 8 patients did not achieve the levels considered necessary to protect neutropenic patients from fungal infections. ... 

Johnson EJ, MacGowan AP, Potter MN, Stockley RJ, White LO, Slade Ri Reeves DS. Reduced absorption of oral ciprofloxacin after chemotiierapy for haematological malignancy. J Antimicrob Chemother ( 990) 25, 837—42. 

ATLS is potentially a catastrophic complication of chemotherapy in patients with a high tumour load. It results from cytotoxic damage to large numbers of cancerous cells. The DNA and RNA released are broken down to uric acid, which precipitates in the renal tubules causing acute uric acid nephropathy. Recent evidence suggests that recombinant urate oxidase, which converts uric acid to soluble allan-toin, is successful in the treatment and prevention of ATLS in patients with haematological malignancies. 

Subramaniam A, Corallo C, Nagappan R. Dapsone-associated methaemoglobinaemia in patients with a haematologic malignancy. Anaesth Intensive Care 2010 38(6) 1070-6. 

Antiangiogenesis in haematological malignancies. British Journal of Haematology, 143, 622-631. 

---