Allogenic haematopoietic stem cell transplantation

Therapy, when replacement of the marrow by allogeneic haematopoietic stem cell transplantation is not possible, comprises 500 mg of methylpred-nisolone by 8 hour intravenous infusion repeated for five consecutive days. Concurrently 15 mg/kg of antilymphocyte or antithymocyte globulin is given... 

Donnelly, J.P. Mouton, J.W. Blijlevens, N.M.A. Smiets, A. Verweij, P.E. Depauw, B.E. Pharmacokinetics of a 14 day course of itraconazole nanocrystals given intravenously to allogenic haematopoietic stem cell transplant (HSCT) recipients. Abstr. Intersci. Conf Antimicrob. Agents Che-mother. 2001, 41, 5. 

A retrospective study reports the efficacy and safety of leflunomide for treatment of BK virus-associated hemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients (n=14). Three days of oral lOOmg/day leflunomide as loading doses followed by maintenance doses of 20mg/day resulted in complete remission in seven patients, six patients achieved partial remission and two patients had a reduction in urinary BKV-DNA load after leflunomide treatment (>l-log BKV-DNA load reduction). One patient discontinued leflunomide therapy because of GI symptoms and 2 case developed neutropenia. Al ough the role... 

Patients (n = 23) who had undergone allogeneic haematopoietic stem cell transplantation were tested for efficacy and side effects resulting from deferasirox treatment due to hyperferritinemia [25 ]. The most common side effect was nausea and vomiting (n=3). 

Serio B, RosamUio R, Giudice V, Pepe S, Zeppa P, Esposiito S, et al. Low-dose valgancyclovir as cytomegalovirus reactivation prophylaxis in allogeneic haematopoietic stem cell transplantation. Infez Med 2012 20(Suppl. 2) 26-34. 

Immunologic In a case series of 179 paediatric allogeneic haematopoietic stem cell transplants, they had a 48% incidence of grade O-I and 52% incidence of grade II-IV acute graft-versus-host disease [175 ]. Only malignant... 

The final chapter comprises two reports on clinical haematopoietic stem cell transplantation (HSCT). Viktor Khomenko shares the experience of the Kiev center for stem cell transplantation. The final article in this book by Axel Zander and colleagues summarises data with the use of Antithymocyte globuline (ATG) in (HLA-mismatched) allogeneic transplantation, an approach which was promoted in the Hamburg Clinic for HSCT. 

The safety and immunogenicity of the heat-treated zoster vaccine was assessed in a randomised, double-blind, placebo-controlled, multicenter study in a diverse population of immunocompromised adults (with solid tumour malignancy (STM), haematological malignancy (HM), HIV, or recipients of autologous haematopoietic stem-cell transplant (HCT) or allogeneic HCT). Importantly, this study showed that in all groups the heat-treated zoster vaccine... 

---