Risk assessment guidelines

TNO Institute of Environmental Sciences, Guidelines for Quantitative Risk Assessment, Amsterdam Netherlands Organization for Applied Scientific Research, 1999. 

Guidelines on Employers Liability and Public Liability Risk Assessment in the Chemical Industry (1992) Guidelines on Material Damage Risk Assessment in the Chemical Industry (3rd edn) (1992)... 

Guidelines on Product Liability Risk Assessment in the Chemical Industry (1992)... 

In recent years, several guidelines and handbooks have been produced to help e.xplain approaches for doing health risk assessments. As discussed by a special National Academy of Sciences committee convened in 1983, most... 

To assess tlie overall potential for noncarcinogenic effects posed by more dian one chemical, a liazard index (HI) approach has been developed based on EPA s Guidelines for Healdi Risk Assessment of Chemical Mixtures. This approach assumes that simultaneous subtlu eshold exposures to several chemicals could result in an adverse healtli effect. It also assumes tliat tlie magnitude of the adverse effect will be proportional to tlie sum of the ratios of the subtlireshold exposures to acceptable exposures. The non cancer hazard index is equal to tlie sum of the hazard quotients, as described below, where E and tlie RfD represent the same exposure period (e.g., subclironic, clironic, or shorter-term). 

If there are specific data germane to the assumption of dose-additivity (e g., if two compounds arc present at the same site and it is known that the combination is five times more toxic than the sum of the toxicitics for the two compounds), then tire development of the hazard index should be modified accordingly. The reader can refer to the EPA (1986b) mi.xiure guidelines for discussion of a hazjird index equation that incorporates quantitative interaction data. If data on chemical interactions are available, but arc not adequate to support a quantitative assessment, note the information in the assumptions being documented for the risk assessment. 

The cancer risk equation described below estimates tlie incremental individual lifetime cancer risk for simultaneous exposure to several carcinogens and is based on EPA s risk assessment guidelines. Tliis equation represents an approximation of the precise equation for combining risks wliich accounts for tlie joint probabilities of tlie same individual developing cancer as a consequence of exposure to two or more carcinogens. The difference between tlie precise equation and tlie approximation described is negligible for total cancer risks less tlian 0.1. Thus, tlie simple additive equation is appropriate for most risk assessments. The cancer risk equation for multiple substances is given by ... 

Note The souree for the above risk values is Table III-7, Preliminary Caneer Poteuey Values for Uie Air Toxies Hot Spots aet, found in California Air Pollution Control Offieers Assoeiation, Air Toxics Hot Spots Program, Revised 1192 Risk Assessment Guidelines," page III-28, published Oetober 1993. 

EPA. 1987e. The risk assessment guidelines of 1986. Washington, DC U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment. EPA/600/8-87/045. 

In 1996, the US Senate and House of Representatives passed the Food Quality Protection Act (FQPA). In order to make their exposure and risk assessments as accurate as possible, the US ERA Office of Pesticide Programs (OPP) has established guidelines to determine a value to assign for NDs. These guidelines can be summarized... 

As per US ERA guidelines, the value used for risk assessment purposes would now be 0.0075 mg kg- thereby permitting up to 26 uses for the product with no detectable residues. 

Ecotoxicological data based on Organization for Economic Cooperation and Development (OECD) guidelines are also required, and the endpoints for aquatic organisms, such as fish, daphnia, algae and aquatic plants, are needed for utilization as part of the risk assessment process. 

O A risk assessment should be performed at presentation of febrile neutropenia to identify low-risk patients for potential outpatient treatment (see Table 96-3). Patients who do not meet low-risk criteria should be hospitalized for parenteral administration of broad-spectrum antibacterials. The IDSA has published evidence-based guidelines for the management of febrile neutropenia5,12 (Fig. 96-1). The choice of initial antimicrobial agent(s) depends on the following factors ... 

Environmental Protection Authority. Review of the Guidelines for Risk Assessment in Western Austraha. 1990. 

This chapter provides general information for performing qualitative or quantitative risk assessments on buildings in process plants. For detailed guidance on risk assessment techniques, the user is referred to other CCPS books on this subject, including Reference 3, Guidelines for Hazard Evaluation Procedures, Second Edition, and Reference 4, Guidelines for Chemical Process Quantitative Risk Analysis. 

Finally, in the risk characterization step, the PEC/PNEC quotient that defines the risk of the substance in the environment is calculated. If the quotient (PEC/PNEC) is less than 1, the substance do not present risk to the environment. More information is available in the European Commission Technical Guidance Document on Risk Assessment [3] and in the United States Environmental Protection Agency s Guidelines for Ecological Risk Assessment [6]. 

United States Environmental Protection Agency (2005). Guidelines for Carcinogen Risk Assessment EPA/630/P-03/001F. Risk Assessment Forum, U.S. Environmental Protection... 

United States Environmental Protection Agency (1998) Guidelines for ecological risk assessment EPA/630/R-95/002F. Washington, DC... 

Human risk assessment (HRA) was done applying guidelines from the Italian Institute for Environmental Protection and Research (ISPRA) and selecting water ingestion as route of exposure for human health assessment [20]. According to the... 

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