Cancer risk assessment guidelines

The approach to hazard identification in the proposed revision of the cancer risk assessment guidelines (EPA, 1996a) differs from the... 

Indeed, in its most recent pubhcation the U.S. EPA, 10/14/98, further supports that approach and the panel members who evaluated the data felt that for the leukemogenic effects of benzene the linear model is consistent with the spirit of the proposed cancer risk assessment guidelines. 

The cancer risk equation described below estimates tlie incremental individual lifetime cancer risk for simultaneous exposure to several carcinogens and is based on EPA s risk assessment guidelines. Tliis equation represents an approximation of the precise equation for combining risks wliich accounts for tlie joint probabilities of tlie same individual developing cancer as a consequence of exposure to two or more carcinogens. The difference between tlie precise equation and tlie approximation described is negligible for total cancer risks less tlian 0.1. Thus, tlie simple additive equation is appropriate for most risk assessments. The cancer risk equation for multiple substances is given by ... 

The following overview of the US-EPA revised quantitative approach for cancer risk assessment is based on the final version of the Guidelines for Carcinogen Risk Assessment (US-EPA 2005). 

Doull J, Cattley R, Elcombe C A cancer risk assessment of di(2-ethylhexyl)phthalate application of the new U.S. EPA risk assessment guidelines. Reg Toxicol Pharmacol 29 327-357, 1999... 

California Air Resources Board/Office of Environmental Health Hazard Assessment, Benzol a] pyrene as a Toxic Air Contaminant (1994) Office of Environmental Health Hazard Assessment/California Environmental Protection Agency, Air Toxics Hot Spot Program Risk Assessment Guideline, Part II Technical Support Document for Describing Available Cancer Potency Factors (1998) Collins et al. (1998). 

Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Air Toxics Hot Spot Program Risk Assessment Guideline Part II Technical Support Document for Describing Available Cancer Potency Factors, 1998. 

Note The source for the above risk values is Table III-7, Preliininaiy Cancer Potency Values for tlie Air Toxics Hot Spots act, found in California Air Pollution Control Officers Association, "Air Toxics Hot Spots Program, Revised 1192 Risk Assessment Guidelines," page III-28, published October 1993,... 

Bostrom CE, Gerde P, Hanberg A, et al. (2002) Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environmental Health Perspectives 110(Suppl. 3) 451 88. 

Because limitations were identified in fhe 1986 carcinogen risk assessmenf guidelines, new cancer risk assessmenf guidelines were set forth that allowed scientists the flexibility to incorporate relevant biological information into the assessment process. 

USEPA (2005). Guidelines for Cancer Risk Assessment, US Environmental Protection Agency, Risk Assessment Eorum, Washington, D.C. 

---