Growth hormone in humans

Tanalta T, Shiu RP, Gout PW, Beer C% Noble RL, Friesen HG. A new sensitive and specific assay for lactogenic hormones Measurement of prolactin and growth hormones in human serum. J Clin Endocrinol Me tab 1980 51 1058-63. 

These compounds release growth hormones in humans and animals. This property has been exploited in producing efficiently the edible meat from animals. 

Ehrlich, R.M., and Randle, P.J. (1961) Immunoassay of growth hormone in human serum. Proceedings of the Royal Society of Medicine, 54, 646-647. 

Kohler, M., Puschel, K., Sakharov, D., et al. (2008) Detection of recombinant growth hormone in human plasma by a 2D-PAGE method. Electrophoresis, 29,4495-4502. 

Reports have appeared in the Hterature of the use of human growth hormone in older men. It has been proposed that a reduction in growth hormone in old age is responsible for increased adipose tissue, loss of lean body mass, and thinning of skin. Current studies conducted on older men indicate the hormone reverses these effects. In the parameters studied the patients resembled those of persons 10 —20 years younger (70). 

Slater MD, Murphy CR. Co-expression of interleukin-6 and human growth hormone in apparently normal prostate biopsies that ultimately progress to prostate cancer using low pH, high temperature antigen retrieval. /. Mol. Histol. 2006 37 37-41. 

Human serum albumin was the first full-length human protein to be expressed in the leaves of a transgenic plant (both tobacco and potato leaves were shown to express the protein). This report was published in 1990 [18]. Four years earlier, Barta and colleagues had demonstrated the expression of human growth hormone in tobacco and sunflower callus, and the protein was expressed as a fusion with the Agrohacterium tumefaciens nopaline synthase enzyme [17]. 

Colthorpe P, Farr SJ, Smith IJ, Wyatt D, Taylor G (1995) The influence of regional deposition on the pharmacokinetics of pulmonary delivered human growth hormone in rabbits. Pharm Res 12 356-359. 

M. Cholewinski, B. Ltickel, H. Horn, Degradation Pathways, Analytical Characterization and Formulation Strategies of a Peptide and a Protein. Calcitonin and Human Growth Hormone in Comparison , Pharm. Acta Helv. 1996, 71, 405-419. 

Somatotropin or growth hormone (GH) Human cadaver pituitaries Treatment of severe GH deficiency in children... 

Kaplan, S.L., L.E. Underwood, G.P August, J.J. Bell, S.L. Blethen, R.M. Blizzard, D.R. Brown, T.P Foley, R.L. Hintz, N.J. Hopwood, et al.. Clinical studies with recombinant-DNA-derived methionyl human growth hormone in growth hormone deficient children. Lancet, 1986.1(8483) 697-700. 

Yeo AL, Levy D, Martin FC, Sonksen P, Sturgess I, Wheeler MM, Young A. Frailty and the biochemical effects of recombinant human growth hormone in women after surgery for hip fracture. Growth Hormone IGF Res 2003 13 361-70. 

Knox JB, Demling RH, Wilmore DW, Sarraf P, Santos AA. Hypercalcemia associated with the use of human growth hormone in an adult surgical intensive care unit. Arch Surg 1995 130(4) 442-5. 

Swerdlow AJ, Higgins CD, Adlard P, Preece MA. Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85 a cohort study. Lancet 2002 360(9329) 273-7. 

Possible role of human growth hormone in penile erection. 

Pikal, M.J., Dellermann, K., Roy, M.L Formulation and stability of freeze-dried proteins effects of moisture and oxygen on the freeze-dried formulation of human growth hormones. In Developments in Biological Standardization,... 

Wroblewski, V.J. (1991) Mechanism of deiodination of 1251-human growth hormone in vivo. Relevance to the study of protein disposition. Biochem. 

Size exclusion HPLC (e.g., human growth hormone) In-Vitro Bioassays... 

Although tobacco is probably the most common host, a range of plant hosts have been shown to function in cell suspension cultures. For example, rice cell cultures produced human growth hormone in the medium at 57 mg/L and showed similar biological activity to human growth factor produced by E. coli (Kim et al., 2008b). Lee et al. (2007) produced biologically active human... 

In 1982 Guillemin et al. 84) and Rivier et al. 85) isolated 3 peptides 43a with GRF activity (stimulation of the secretion of growth hormone) from human pancreatic tumor cells, and synthesized them by the solid-phase method ... 

Zwickl CM, Cocke KS, Tamura RN, Holzhausen LM, Brophy GT, Bick PH, Wierda D. Comparison of the immunogenicity of recombinant and pituitary human growth hormone in rhesus monkeys. Fund Appl Toxicol 1991 16 275-87. 

Chihara K, Kashio Y, Kita T, Okimura Y, Kaji H, Abe H, Fujita T (1986) L-DOPA stimulates release of hypothalamic growth hormone-releasing hormone in humans. J Clin Endocrinol Metab (52 466-473. 

Tl. Teh, L. C., Murphy, L. J., Huq, N. L., Surus, A. S., Friesen, H. G., etal., Methionine oxidation in human growth hormone and human chorionic somatomammotropin. Effects on receptor binding and biological activities. J. Biol. Chem. 262, 6472-6477 (1987). 

---