Grip strength

Incorporate other measures to track disease progress. Use radiography to assess severity of joint destruction, determine 50-ft walking time and grip strength, and administer the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the Stanford Health Assessment Questionnaire, where appropriate, to assess activities of daily living. 

Depending on the joint affected, measurement of grip strength and 50-feet walking time can help assess hand and hip/knee OA, respectively. 

The effect of -hexane exposure on nerve conduction velocity was investigated in male Wistar rats exposed to ft-hexane at 0, 500, 1,200, or 3,000 ppm 12 hours a day for 16 weeks (Huang et al. 1989). From week 12, a marked decrease in grip strength and slowness of action were observed in the... 

In a study where both peripheral and central nervous system effects were measured in rats co-exposed to u-hexane and toluene (Pryor and Rebert 1992), toluene exposure at 1,400 ppm for 14 hours a day for 9 weeks prevented the peripheral neurotoxicity (decreased grip strength and nerve conduction velocities) caused by exposure to 4,000 ppm 77-hcxanc alone. There was no reciprocal action of 77-hexane on the motor syndrome (shortened and widened gait and widened landing foot splay) and hearing loss caused by toluene. Brainstem auditory response amplitudes were decreased by 77-hcxanc, co-exposure to toluene did not block this effect. 

Specific test for sedative, excitatory effects of compoimds Neuromuscular function Assessment of grip strength Rotarod... 

Measure of the grip strength of the forelimbs or hindlimbs may be evaluated quantitatively or by subjective estimate or impairment (rodents only). 

Muscle strength Force Grip strength Rat Horner et al.192... 

Functional observations (4th exposure week - sensory reactivity to stimuli of different types, grip strength,... 

Organ weights (spleen, thymus, all animals) Immunotoxicity tests (1) functional tests (either a splenic plaque-forming cell (PEC) assay or an Enzyme-Linked Immunosorbent Assay (ELISA) to determine the response to antigen administration) (2) enumeration of splenic or peripheral blood total B cells, total T cells, and T-cell subpopulations Detailed clinical observations Functional observations (sensory reactivity to stimuli of different types, grip strength, motor activity, more specialized tests on indication)... 

IV- Dantrolene IV may decrease the grip strength and increase weakness of leg muscles, especially walking down stairs. 

Body weight External examination Grip strength Immunophenotyping Clinical pathology Milk sampling Toxicokinetics... 

Therapeutic response, such as improved grip strength, increased joint mobility, and decreased joint pain, tenderness, stiffness, and swelling... 

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