Green tea polyphenols -Epigallocatechin

Tobi SE, Gilbert M, Paul N and McMillan TJ. 2002. The green tea polyphenol, epigallocatechin-3-gallate, protects against the oxidative cellular and genotoxic damage of UVA radiation. Int J Cancer 102(5) 439-444. 

Katiyar, S.K. and Mukhtar, H., Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress, J Leukoc Biol, 69, 719, 2001. 

Mandel S, Weinreb O, Amit T, Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (—)-epigallocatechin-3-gallate, implications for neurodegenerative diseases, JNeurochem 88 1555—1569, 2004. 

Hastak K, Agarwal MK, Mukhtar H, Agarwal ML. 2005. Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin-3-gallate. FASEB J 19 789-791. 

Katiyar SK, Afaq F, Azizuddin K, Mukhtar H. 2001. Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (—)-epigallocatechin-3-gallate. Toxicol Appl Pharmacol 176 110-117. 

Sakata R, Ueno T, Nakamura T, Sakamoto M, Torimura T, Sata M. 2004. Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90. J Hepatol 40 52-59. 

Kalfon L, Youdim MB, Mandel SA. 2007. Green tea polyphenol (-)-epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad Implications for neuroprotection. J Neurochem 100 992-1002. 

Levites Y, Weinreb O, Maor G, Youdim MB, Mandel S. 2001. Green tea polyphenol (—)-epigallocatechin-3-gallate prevents N-mcthyl-4-phcnyl-l, 2,3,6-tctrahydropyri-dine-induced dopaminergic neurodegeneration. J Neurochem 78 1073-1082. 

Spinella F, Rosano L, Di Castro V, Decandia S, Albini A, Nicotra MR, Natali PG, Bagnato A. 2006. Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma. Mol Cancer Ther 5 1483-1492. 

Levites, Y., Amit, T., Mandel, S., and Youdim, M.B., Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J, May, 17(8), 952-954, 2003. 

Ahmed, S. et al. Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes. J Pharmacol Exp Ther. 308, 767, 2004. 

Bursill, C. A., Roach, P. D. (2006). Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells. J. Agric. Food Chem., 54, 1621-1626. 

Yang, R, Oz, H. S., Barve, S., de Villiers, W. J., McClain, C. J., Varilek, G. W. (2001). The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting 1 kappa B kinase activity in the intestinal epithelial cell line IEC-6. Molecular Pharmacology, 60, 528-533. 

Levites, Y, Weinreb, O., Maor, G., Youdim, M.B.H., and Mandel, S. Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyM-phenyl-1,2,3,6- tet-rahydropyridine-induced dopaminergic neurodegeneration, J. Neurochem., 78, 1073-1082, 2001. 

FIGURE 8.19 Proposed scavenging mechanism of epigallocatechin gallate to nitrite ions. (From Panzella, L., Manini, P., Napolitano, A., and d Ischia, M. 2005. The acid-promoted reaction of the green tea polyphenol epigallocatechin gallate with nitrite ions. Chem. Res. Toxicol. 18 722-29. With permission.)... 

Ahmed, S., Rahman, A., Hasnain, A., Lalonde, M., Goldberg, V. M., and Haqqi, T. M. 2002. Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic. Biol. Med. 33 1097-105. 

Green tea polyphenol epigallocatechin-3-gallate protects cells against peroxynitrite-induced cytotoxicity modulatory effect of cellular G6PD status. 

Liberto M, Cobrinik D (2000) Growth factor-dependent induction of p21(CIPl) by the green tea polyphenol, epigallocatechin gallate. Cancer Lett 154 151-161... 

Pianetti, S, Guo, S, Kavanagh, KT, and Sonenshein, GE, Green tea polyphenol epigallocatechin-3 gallate inhibits her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells. Cancer Res, 2002. 62(3) 652-655. 

Siddiqui lA, Adhami VM, Bharali DJ, Hafeez BB, Asim M, Khwaja SI et al. Introducing nanoche-moprevention as a novel approach for cancer control Proof of principle with green tea polyphenol epigallocatechin-3-gallate. Cancer Res. 2009 69(5) 1712-1716. 

Ahmad, N., Gupta, S., and Mukhtar, H. Green tea polyphenol epigallocatechin-3-gaIIate differentially modulates nuclear factor kB in cancer cells versus normal cells. Archives of Biochemistry and Biophysics. 376 338-346 (2000). 

Forester SC, Gu Y, Lambert JD. Inhibition of starch digestion by the green tea polyphenol, (—)-epigallocatechin-3-gallate. Mol Nutr Food Res. 2012 56(11) 1647-1654. 

Levites Y, Amit T, Youdim MB, Mandel S (2002) Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (—)-epigallocatechin 3-gallate neuroprotective action. J Biol Chem 277(34) 30574—30580. doi 10.1074/jbc. M202832200M202832200 [pii]... 

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