Hepatic stellate cells, human

Sakata R, Ueno T, Nakamura T, Sakamoto M, Torimura T, Sata M. 2004. Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90. J Hepatol 40 52-59. 

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Y. N. Park, C. P. Yang, O. Cubukcu, S. N. Thung, and N. D. Theise, Hepatic stellate cell activation in dysplastic nodules Evidence for an alternate hypothesis concerning human hepatocarcinogenesis, Liver 17 271-274 (1997). 

V. Carloni, R. G. Romanelli, M. Pinzani, G. Laffi, and P. Gentilini, Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells, Gastroenterology 110 1127-1136 (1996). 

A. Casini, E. Ceni, R. Salzano, P. Biondi, M. Parola, A. Galli, M. Foschi, A. Caligi-uri, M. Pinzani, and C. Surrenti, Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells role of nitric oxide, Hepatology 25 361-367 (1997). 

L. Beljaars, G. Molema, B. Weert, H. Bonnema, P. Olinga, G. M. M. Groothuis, D. K. F. Meijer, and K. Poelstra, Albumin modified with mannose 6-phosphate a potential carrier for selective delivery of anti-fibrotic drugs to rat and human hepatic stellate cells, Hepatology 29 1486-1493 (1999). 

Figure 29-4. Stellate cell lipid droplets present in a biopsy obtained from the liver of a patient experiencing vitamin A toxicity. Image obtained from electron microscopy of a biopsied human liver showing the characteristic lipid droplets (LD) found in hepatic stellate cells (SC).These lipid droplets are highly enriched in vitamin A, and the size and number of lipid droplets is influenced by dietary vitamin A intake and nutritional status. In this image of a human stellate cell, the nucleus (N) is compressed by the surrounding lipid droplets, and very little cell cytoplasm within the stellate cell can be seen in this view.Adjoining the stellate cell are two hepatocytes (H).

Shibata N, Watanabe T, Okitsu T, et al. (2003). Establishment of an immortalized human hepatic stellate cell line to develop antifibrotic therapies. Cell Transplant. 12 499-507. 

A marked activation of AP-1 nuclear binding as induced by 1-10 pM 4-HNE, has now been demonstrated in different cytotypes including murine and human macrophageshuman hepatic stellate cells, and rat hepatocytes. With regard to another well-studied redox-sensitive transcription factor, NF-kB, 4-HNE does not appear to influence its activation and nuclear translocation in the mentioned cyto-types. Moreover, in nemoblastoma-derived PC 12 cell line, 4-HNE activates AP-1 and significantly downregulates NF-kB nuclear binding. ... 

Parola, M., G. Robino, F. Marra, M. Knzani, G. Bellomo, G. Leonarduzzi, R Chiarugi, S. Camandola, G. Poll, G. Waeg, P Gentilini, and M.U. Dianzani. 1998. HNE interacts directly with JNK isoforms in human hepatic stellate cells. J. Clin. Invest. 102 1942-1950. 

Marek CJ, Tucker SJ, Korath M, Wallaee K, Wright MC (2007) Expression of CYP2S1 in human hepatic stellate cells. FEES Lett 581 781 786... 

Tan-I inhibited cell growth dose dependently at concentrations ranging from 0.5 to 25 pM and induced apoptosis in activated T-HSC/C-6 hepatic stellate cells. Tan-1 increased caspase-3 activation via cytochrome c release and loss of mitochondrial membrane potential [48]. Nizamutdinova and coworkers investigated the effect of Tan-1 on the induction of apoptosis in human breast cancer cells (MCF-7 and MDA-MB-231) in vitro. Tan-I inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose- and time-dependent manner and significantly induced apoptosis in MCF-7 and MDA-MB-231 cells. The induction of apoptotic cell death was mediated by the activation of caspase-3 the downregulation in the level of the... 

M. L. Hautekeete and A. Geerts, The hepatic stellate (Ito) cell Its role in human liver disease, Virchows Arch. 430 195-207 (1997). 

Narushima M, Kobayashi N, Okitsu T, et al. (2005). A human beta-cell line for transplantation therapy to control type 1 diabetes. Nat. Biotechnol. 10 1274-1282. Watanabe T, Shibata N, Westerman K A, et al. (2003). Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers. Transplant. 75 1873-1880. 

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