Polyphenols green tea

Vayalil PK, Mittal A, Kara Y, Elmets CA, Katiyar SK (2004) Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metal-loproteinases expression in mouse skin. J Invest Dermatol 122 1480-1487... 

ELMETS C A, SINGH D, TUBESING K, MATSUI M, KATIYAR S and MUKHTAR H (2001) CutaneOUS photoprotection from ultraviolet injury by green tea polyphenols , JA mAcad Dermatol, 44, 425-32. 

KATIYAR s K, ELMETS c A, AGARWAL R and MUKHTAR H (1995) Protection against ultraviolet-B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols , Photochem Photobiol, 62, 855-61. 

KATIYAR s K, PEREZ A and MUKHTAR H (2000b) Green tea polyphenol treatment to hiunan skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA , Clin Cancer Res, 6 (10), 3864-9. 

SAKANAKA s, SATO T, KIM M and YAMAMOTO T (1990) Inhibitory effects of green tea polyphenols on glucan synthesis and cellular adherence of cariogenic streptococci , Agric Biol... 

SAKANAKA s (1995) Anti-caries and anti-periodontal disease effects of green tea polyphenols , in Proc of Intern Symp on Tea-Quality-Human Health, 7-10 December, 1995, Shanghai, China, 97-106. 

UNTEN L, KOKETSU M and KIM M (1997) Antidiscoloring activity of green tea polyphenols on beta-carotene , JAgric Food Chem, 45, 2009-12. 

J (2001) Green tea polyphenol extract attenuates inflammation in interleukin-2-deficient mice, a model of autoimmunity , J Nutr, 131 (7), 2034-9. 

KOBAYASHI Y, SUZUKI M, SATSU H, ARAI S, KARA Y, SUZUKI K, MIYAMOTO Y, SHIMIZU M (2000) Green tea polyphenols inhibit the sodiiun-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. JAgric Food Chem. 48 5618-23. 

On patients with cancer, the effects of green tea catechins, soy isoflavones and quercetin as chemoprotective/chemotherapeutic agents have also been studied. Although results have not been entirely satisfactory, a partial response has been achieved in some trials. For example, small decreases in plasma concentration of prostate-specific antigen were observed in prostate cancer patients who consumed soy isoflavones. Nevertheless, results in individuals with premalignant disease who consumed green tea polyphenols support their advancement into phase III clinical intervention trials aimed at the prevention of PIN, leukoplakia, or premalignant cervical disease (Thomasset and others 2006). 

Potenza MA, Marasciulo FL, Tarquinio M, Tiravanti E, Colantuono G, Federici A, Kim JA, Quon MJ and Montagnani M. 2007. EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR. Am J Physiol Endocrinol Metab 292(5) E1378-E1387. 

Yamane T, Nakatani H, Kikuoka N, and others. 1996. Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis. Cancer 77(8 Suppl) 1662-1667. 

Tobi SE, Gilbert M, Paul N and McMillan TJ. 2002. The green tea polyphenol, epigallocatechin-3-gallate, protects against the oxidative cellular and genotoxic damage of UVA radiation. Int J Cancer 102(5) 439-444. 

Unfortunately, to date, no formal clinical studies have been conducted to specifically evaluate the effects of green tea, green tea extracts, or EGCG on immune function. However, based on several Phase I studies that have evaluated EGCG and/or Polyphenon E (a defined, decaffeinated green tea polyphenol mixture) and found them to be safe and tolerable at relatively high doses, it is likely that future clinical studies may follow [66-69],... 

Chow, H.H. et al., Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals, Clin Cancer Res, 9, 3312, 2003. 

Yang, F. et al., Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model, JNutr, 128, 2334, 1998. 

Katiyar, S.K. and Mukhtar, H., Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress, J Leukoc Biol, 69, 719, 2001. 

Sakanaka S, Shimura N, Aizawa M, Kim M and Yamamoto T (1992) Preventive effect of green tea polyphenols against dental caries in conventional rats. Biosci Biotech Biochem 56, 592-594. 

Mandel S, Weinreb O, Amit T, Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (—)-epigallocatechin-3-gallate, implications for neurodegenerative diseases, JNeurochem 88 1555—1569, 2004. 

Lin, Y. L., I. M. Juan, Y. L. Chen, Y. C. Liang and J. K. Lin. Composition of polyphenols in fresh tea leaves and associations of their oxygen-radical-absorbing capacity with antiproliferative actions in fibroblast cells. J Agr Food Chem 1996 44(6) 1387-1394. Davis, A. L., Y. Cai, A. P. Davies and J. R. Lewie. H and NMR assignments of some green tea polyphenols. Magn Reson Chem 1996 34(11) 887-890. 

Tanaka, T., Mine, C., and Kuono, I., Structures of two new oxidation products of green tea polyphenols generated by model tea fermentation. Tetrahedron, 58, 8851, 2002. 

Locher, R., Emmanuele, L., Suter, P.M., Vetter, W., and Barton, M., Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein, Eur. J. Pharmaeol, 434, 1, 2002. 

Davies, A.L. et al., H and assignments of some green tea polyphenols, Magn. Reson. Chem.,... 

Jodoin J, Demeule M, Beliveau R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochem Biophys Acta 2002 1542 149-159. 

Haqqi et al. (1999) investigated the impact of polyphenols present in green tea on rheumatoid arthritis (RA). The study used mice as test subjects and showed that although 92% of ordinary mice developed RA when injected with a compound that induced RA, less than half of the mice that consumed the green tea polyphenols developed RA after a similar injection. 

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