Good lab practices

For employee training. Good lab practices and general lab safety. National Safety Council Purchase 475... 

Samples applied with the ATS 4 can be positioned for normal, double-sided, or circular chromatographic development. Analyses performed with this applicator, combined with densitometric chromatogram evaluation controlled by the same PC with Windows-based WinCats software, comply with good manufacturing practices/ good lab practices (GMP/GLP), installation qualification (IQ)/operational qualification (OQ), and 21 Code of Federal Regulations (CFR) Part 11 (drug analysis) requirements. 

Minimize the risk by preventing exposure using good lab practices and personal protective equipment. 

Minimize the risk by preventing exposure using good lab practices and personal protective equipment such as gloves and using ventilation hoods for inhalation hazards. Follow specific requirements stated in compound-specific OSHA standards. 

Make a list of good laboratory practices for the lab accompanying this course (or another lab if this course does not have an associated laboratory). Explain the rationale for each item on your list. 

Calibration. Cahbration of lab instmments is important to the accuracy of test results. CaUbration, the use of an accepted standard to adjust an instmment or measurement standard so as to improve the accuracy of the instmment or measurement, is an essential requirement of both the U.S. Food and Dmg Administration (FDA) Good Manufacturing Practice (GMP) (24) and the ISO 9000 standards (25). 

Maintain good housekeeping practices (e.g., on ending an experiment, be sure to return all radionuchdes to their safe storage locations, dispose of all contaminated items, and decontaminate surfaces). Remember that any unsuitably shielded waste can be hazardous to lab workers and custodial personnel. 

On February 10 and 11 (1987, we) met in Geneva, New York and informally audited the Good Laboratory Practices (GLP s) and performed a Quality Assurance (QA) audit of. .. projects chosen at random. It was intended for the laboratory personnel to understand that the audit process would be helpful to their organization and also helpful to the. .. program. The entire staff of the Geneva labs participated in the process in a very cooperative and hospitable manner. 

While handling all materials stored in chloroform under nitrogen at -80°C, allow them stabilize at room temperature before opening and using them. This is good lab safety practice. 

Good housekeeping is conducive to good safety practices. Keep your work area clean and uncluttered. No books, purses, coats, etc., on lab benches. 

Now, many of these concerns relevant to the FBI lab are not apphcable to many other laboratories. But they illustrate the importance of instituting good laboratory practices. Had the FBI lab been more diligent in the care of its practices, it may have avoided the turmoil of this investigation. 

The QAU is responsible for assuring good laboratoiy practices are implemented. Everyone in the lab is responsible for following them. 

This chapter introduces the most important aspect of TEQA for the reader After the basics of what constitutes good laboratory practice are discussed, the concept of instrumental calibration is introduced and the mathematics used to establish such calibrations are developed. The uncertainty present in the interpolation of the calibration is then introduced. A comparison is made between the more conventional approach to determining instrument detection limits and the more contemporary approaches that have recently been discussed in the literature (1-6). These more contemporary approaches use least squares regression and incorporate relevant elements from statistics (7). Quality assurance/quality control principles are then introduced. The chapter ends with a comparison of the performance from two hypothetical labs. Every employer wants to hire an analyst who knows of and practices good laboratory behavior. 

The next topic in this chapter introduces the two tenants of Good Laboratory Practice (GLP), quality assurance, and quality control. This is a topic of utmost importance, particularly to laboratory managers and corporate executives A good lab with a lousy GLP is a sad use of human and facility resources. Each batch of samples that are analyzed must include, in addition to the samples themselves, a matrix spike, a matrix spike dupli-... 

Differences in cultures in developing countries can also affect security practices in the laboratory. Cultural challenges include excessive hierarchy of power, too much trust in others, lack of a culture of sharing, lack of accountability, hiding or not reporting security lapses, frequent visits to the labs by friends and acquaintances, and not recognizing good security practices of others. 

Minimize the risk of lab accidents and exposure with good housekeeping practices. 

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