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Gonadotropins cells

In premenopausal women the ovary is the richest source of aromatase and hence estrogen. Aromatase is confined to the granulosa cells and is produced under the influence of gonadotropins (FSH and LH). Despite being a rich source of aromatase, three separate studies have shown that aromatase inhibitors are unable to sufficiently suppress ovarian estrogen production to postmenopausal levels. One explanation for this phenomenon may be a compensatory rise in gonadotrophins which maintains adequate estrogen production, despite the presence of the inhibitor. As such aromatase inhibitors cannot be used in premenopausal breast cancer patients. After menopause, ovarian... [Pg.219]

Dong KW, Chen ZG, Cheng KW, Yu KL (1996) Evidence for estrogen receptor-mediated regulation of human gonadotropin-releasing hormone promoter activity in human placental cells. Mol Cell Endocrinol 117 241-246... [Pg.141]

Fowler PA, Sorsa-Leslie T, Cash P, Dunbar B, Melvin W, Wilson Y, Mason HD, Harris W (2002) A 60-66 Kda protein with gonadotropin surge attenuating factor bioactivity is produced by human ovarian granulose cells. Mol Hum Reprod 8 823-832... [Pg.142]

Neaves, W. B., Johnson, L., Porter, J. C., Parker, C. R. and Petty, C. S. (1984). Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. Journal of Clinical Endocrinology and Metabolism 59, 756-763. [Pg.188]

R.G. Richards, S.M. Hartman, and S. Handwerger. Human cytotrophoblast cells cultured in maternal serum progress to a differentiated syncytial phenotype expressing both human chorionic gonadotropin and human placental lactogen. Endocrinology. 135 321-329 (1994). [Pg.389]

Germ cell tumors Chorionic gonadotropin, alpha-fetoprotein, placental lactogen, placental alkaline phosphatase... [Pg.428]

HCG human chorionic gonadotropin HCL hairy cell leukemia Hct hematocrit HCTZ hydrochlorothiazide HD hemodialysis HDAC histone deacetylase Hep hepatitis hepatotox hepatotoxicity HER2 type of cancer gene HF heart failure HFA designation for type of inhalation device Hgb hemoglobin HIT/HITTS heparin-mduced thrombocytopenia... [Pg.447]

An examination by the dentist should eliminate many of the potential systemic issues that can affect the periodontium of this patient. For example, the age of the patient, her appearance, and questions about her diet should be enough to rule in or out issues concerning puberty and malnutrition. However, if systemic conditions cannot be ruled out, an additional physical examination by a physician may be necessary. Additional tests to be requested could include oral glucose tolerance test for diabetes mellitus, human chorionic gonadotropin levels for pregnancy, and/or qualitative and quantitative evaluation of bone marrow cells and blood cells for leukemia. [Pg.506]

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See also in sourсe #XX -- [ Pg.170 ]



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