Glycols, TMS ethers

Tms (trimethylsilyl) = MejSi triglyme triethylene glycol dimethyl ether =... 

Development of sterically stabilized liposomes (SSL) composed of high Tm lipids, cholesterol, and a lipopolymer, such as poly-(ethylene glycol methyl ether)-l,2-distearoyl-i n-glycero-3-phospho-ethanolamine triethyl ammonium salt (1,3-5,8,9,14,15)... 

Langer and co-workers [24,25] converted alcohols and phenols prior to GC analysis into TMS ethers by the action of HMDS. The method using silylation with HMDS—TMCS (2 1) was used for the GC of ethylene and diethylene glycols on Apiezon L [26], glycerol on SE-30 [27], polyethers of glycols on XE-61 [28], hydroxystilbenes on SE-52 [29], some flavonoides and related substances on SE-30 [30], plant phenols and related substances on OV-1, OV-17 and OV-25 [31], anthocyanines on OV-225 [32] and amino-chromes on SE-30 [33], Different terpene alcohols were silylated by Seidenstucker [34] within 10 min by heating at 40-60°C with a 6—8-fold excess of TMS-acetamide. The separation was performed on a stainless-steel column (50 m X0.25 mm I.D.) coated with Apiezon L. 

Dioxitol [Shell], TM for diethylene glycol monoethyl ether, bp 202C, d 0.990 (20/20C). 

Methoxyethoxy)elhoxy)ethanol Methoxytrielhylene glyc-ol Methoxytriglycol Melhyltrioxitol NSC 97395 Poly-Solv TM Triethylene glycol methyl elhen Triethylene glycol monomethyl ether Triglycol monomethyl ether 3,6,9-Trioxa-1-decanol. 

Propanol, 1-(2-(2-methoxy-1-methylelhoxy)-1-methyl-ethoxy)-. 4-01-00-02475 (Beilstein Handbook Reference) BRN 1701854 Dowanol 62B Dowanol TPM glycol ether EINECS 243-734-9 1- 2-(2-Methoxy-1-methylethoxy)-1-methylethoxy)propan-2-ol 2-Propanol, 1-(2-(2-methoxy-1-methylethoxy)-1-methylethoxy)- Propasol solvent TM Tripropylene glycol methyl ether Tripropylene glycol monomethyl ether. 

Poly-Solv TM, triethylene glycol monomethyl ether... 

MSTFA was also the derivatizing agent of choice for the direct derivatization of flutroline in plasma extracts on the tip of a moving needle injector prior to GC-MS selected ion monitoring (SIM) assay [22]. TMS derivatives of formaldehyde condensates, formed in a gas phase reaction with BSTFA, were used for the separation and quantification of methylal (dimethoxymethane), methylene glycol and a series of poly(oxymethylene) glycol monomethyl ethers by capillary GC-MS using ammonia chemical ionization [23]. The possibility of accelerated... 

The g.l.c. separation of various methylated derivatives of mannose, galactose, and glucosamine as their trimethylsilylated derivatives has been described using 0.3-0.4% OV 225 on Chromosorb that had been surface modified by a high molecular weight polyethylene glycol. Conditions have been found for the separation of the TMS ethers of arabinose, xylose, mannose, ot- and /3-glucose, fructose, sorbose, xylitol, mannitol, and sorbitol on Chromosorb W-NAW with 15% Carbowax 20M, and a g.l.c. method for the quantitative determination of trehalose as its TMS ether has been reported." ... 

TM Triethylene glycol monomethyl ether Ethanol, 2-[2-(2-methoxyethoxy)ethoxy]- 112-35-6 ... 

Ethylene glycol/H, CUSO4 Trimethyltrifluoromethyl silane Silylating reagents (for synthesis of enols TMS ethers)... 

The tested enhancers were benzalkonium chloride (BZ), polyoxyethylene glycol lauryl ether (Brij 35), Polyoxyethylene glycol stearyl ether (Brij 78), Polyoxyethylene glycol oleyl ether (Brij 98), ethylenediaminetetraacetic acid, Na salt (EDTA), digitonin (DIG), sodium taurocholate (TC) and saponine (SAP). The results of the study are summarized in Table 3. In the absence of enhancers, the comeal permeability of the less lipophilic TM was lower than those of LB and CY, in agreement with literature data. In general, the enhancers increased the rate of permeation of TM more than those of the other two, more lipophilic... 

Mono ycerides Diethylene glycol succinate (DECS) Apiezon L TMS ethers... 

The best way to identify the MWs of unknown glycols and glycol ethers is to examine the mass spectra of the TMS derivatives. The TMS derivatives are identified in the chromatogram by plotting masses 73 and 147. The higher of the two high-mass peaks, which are 15 Daltons apart, is the molecular ion of the TMS derivative. If no peaks are separated by 15 Daltons, add 15 to the highest mass peak observed to deduce the MW. 

Cimbura and Kofoed (50),mentioned earlier, used GLC to separate amphetamine and methamphetamine after acetylation with acetic anhydride in methanol. Derivatives were extracted using diethyl ether and chromatographed op columns of either 3% OV-17, OV-1, or SE-30. Column temperature was 160°C. They also reported the chromatographic determination of acetylated morphine on 3% SE-30, OV-1, or OV-17 at temperatures of 220°C. Cruickshank et al.(21) separated 21 amino acids as their trifluoroacetylated methyl esters. The column was 5% neopentyl glycol succinate on Gas Chrom P. Column temperatures were both isothermal and programmed 65°C for 20 min at 1.5°C/min then 2°C/min until 42.5 min then 4°C/min until 60 min then isothermal until about 75 min (see Figure 12.2). Chang et al. (19), used BSA/pyridine to form the TMS derivatives of levodopa, methyldopa, tyrosine. 

Adiprene [Du Pont], TM for a polyurethane rubber, the reaction product of diisocyanate and polyalkylene ether glycol. In its raw polymer form, it is a liquid of honey-like color and consistency, which is compounded chemically (to polymerize it further) and converted into products by casting and other techniques. 

---