5-Ethoxy-4-methyl

Essigsaure -cycloheptylamid E5, 1035 (HjC —CN + R-I/HzO) Furan 4,4-Diethyl-5-imino-2-methyl-tetrahydro- VI/2, 611 Hexanal 2-(Dimethylamino-methylen)- Vl/ld, 35f. Hexansaure 5-Ethoxy-4-methyl- -nitril E19a, 810 (Alkohol + En/+ En)... 

To solution of 2-isocyanopropanenitrile (1.6g, 20nunol) in methanol (15 ml) is added potassium carbonate (0.2 g), and the mixture is stirred at room temperature (20 h). After filtering, and removing the solvent under reduced pressure, the cmde product is crystallized from cyclohexane (1.6 g, 70%), m.p. 88-89°C. Similarly prepared are 5-ethoxy-4-methyl- (62% from cyclohexane, m.p. 94°C), 5-methoxy-4-isopropyl- (75% from benzene, m.p. 96-97°C), 5-ethoxy-4-isopropyl- (51% from benzene, m.p. 122-123°C), 5-ethylthio-4-methyl- (58% from cyclohexane, m.p, 88°C), 5-benzylthio-4-methyl- (61% from benzene, m.p. 156 C), 5-ethylthio-4-isopropyl- (55% from cyclohexane, m.p. 124°C), and 5-benzyl thio-4-isopropylimidazoles (45% from benzene, m.p. 133°C). 

Alkoxyoxazoles have also proven to be valuable heterodienes in the synthesis of highly substituted furans and biologically active natural products via oxazole-aUtyne Diels-Alder reactions. Thus the synthesis of a synthon for the DEF ring system of fredericamycin began with the cycloaddition of 5-ethoxy-4-methyl-oxazole 8 with enyne ester 149 (Fig. 3.45). This reaction proceeded in 24 h in refluxing toluene to afford a 65% yield of the 2-ethoxyfuran 150. Furan 150 was then converted to the isoquinoline 151 in six steps. ... 

Piperonyl butoxide [51-03-6] is 5-[2-(2-butoxyethoxy)ethoxy]methyl-6-propyl-l,3-benzodioxole (11) d 1.04—1.07, vp 0.13 kPa at 25°C). The rat oral LD qS are 7500, 6150 mg/kg. Piperonyl butoxide is the synergist commonly used with natural pyrethrins in aerosol sprays. 

Pyrimidin-4-amine, N, N-dimethyl-2-methylthio-demethylation, 3, 95 Pyrimidin-4-amine, 5-ethoxy methyl-... 

The cleavage proceeds by initial reduction of the nitro groups followed by acid-catalyzed cleavage. The DNB group can be cleaved in the presence of allyl, benzyl, tetrahydropyranyl, methoxy ethoxy methyl, methoxymethyl, silyl, trityl, and ketal protective groups. 

Chemical Name 2-[ [2-[3-(Acetylamino) -2,4,6-triiodophenoxy] ethoxy] methyl] -butanoic acid... 

Tributyl(l-ethoxy-2-propenyl)stannane (2) was first prepared from tributyl[chloro(ethoxy)-methyl]stannane and vinylmagnesium bromide, and found to be unstable with respect to 1,3-migration of the tributyltin substituent101. Tributyl(l-ethoxy-3-methyl-2-butenyl)stannane (1) was found to be more stable, and has since been prepared directly from (tributyl)(diethoxy-methyl)stannane and 2-methylpropenylaluminum dichloride generated in situ102. 

CN ( )-l-[4-[[2-(l-methylethoxy)ethoxy]methyl]phenoxy]-3-[(l-methylethyl)amino]-2-propanol... 

CN 2-amino-l,9-dihydro-9-[[2-hydroxy-l-(hydroxymethyl)ethoxy]methyl]-6//-purin-6-one monosodium salt... 

Deres K, Schroder CH, Paessens A, Goldmann S, Hacker HJ, Weber O, Kramer T, Niewohner U, Pleiss U, Stoltefuss J et al. (2003) Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science 299 893-896 Ehon GB, Furman PA, Fyfe JA, de Miranda P, Beauchamp L, Schaeffer HJ (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxy ethoxy methyl) guanine, Proc Natl Acad Sci USA 74 5716-5720... 

The catalytic arylation of SEM-protected azoles (SEM = [2-(trimethylsilyl) ethoxy]methyl) with monocarbene-Pd(ll) complexes [72], and the reductive Heck or hydroarylation of norbomenes with NHC-phosphine chelating ligands... 

Shenlin Huang has implemented method C with 2,4-bis-OBoc-3-bromobenzyaldehyde 27 (Fig. 4.22) and 2-(trimethylsilyl)ethoxy]methyl-lithium 38 at —78 °C in THF.24 Surprisingly, lithium-halogen exchange does not happen and the intermediate benzyl alcohol undergoes reduction with sodium borohydride in the same pot to afford the desired bromophenol 39 in 68% yield. This material... 

Ethoxy(methyl)phosphoryl] sulfanyl -N,N,N-triethylethanaminium Iodide... 

Ethoxy(methyl)phosphoryl] sulfanyl -N,N-diethyl-N-methylethanaminium Iodide 2- [Ethoxy(methyl)phosphoryl]sulfanyl -N-ethyl-N,N-dimethylethanaminium Iodide 2-Ethylpropanoic Acid... 

N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropyl-N-methylpropan-2-aminium Iodide N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropylpropan-2-aminium Chloride N-(2-Chloroethyl)dimethylamine N-(2-Chloroethyl)-N,N-dimethylamine N-(2-Hydroxyethyl)diethylamine N-(4-Oxy-3-methoxybenzyl)-8-methyl-6-nonenamide N-(Diethylamino)ethanol N-(Isopropyl)-2-propamine... 

Dissolve 3.3 g 4,5, or 6 methoxy (or ethoxy, methyl, etc.)-tryptamine or its HC1 salt in 350 ml 0.1 N HC1 heat on steam bath two hours with 1.1 g glycoaldehyde (reaction over when aliquot no longer gives a precipitate with dinitrophenylhydrazine). Filter, concentrate by heating on water bath or evaporate in vacuum basify with 20% NaOH and extract with ether (best to do in an extractor for eighteen hours). Dry and evaporate in vacuum the extract to get about 5 g residue or oil which may precipitate on standing. Add 250 ml 90% phosphoric acid and heat on steam bath two hours. Evaporate in vacuum (or dilute with water, basify with 20% NaOH extract with ether in extractor and dry, evaporate in vacuum the... 

Dissolve 27 g 4,5, or 6 methoxy (or ethoxy, methyl, etc.) tryptophan in 50 ml freshly distilled acetaldehyde and 1 L water and heat at 50° in loosely stoppered flask three hours. Heat on steam bath five hours to remove acetaldehyde, then add 5 L water and heat to boiling. Add 1.2 L 10% K dichromate and 240 ml glacial acetic acid and continue heating three minutes. Cool and add excess Na sulfite take pH to 8 with Na carbonate Extract with 5 L ether and dry, evaporate in vacuum (or simply evaporate in vacuum after cooling) to get the harmaline isomer. 

The procedure was proved to be general for the preparation of protected hydroxy acids from lactones (121). This apparently trivial process is often difficult to carry out, as the attempted derivatization of y or J-hydroxyacids frequently results in relactonization rather than hydroxyl protection. The method was applied to several aldonolactones to produce the corresponding intermediate hydroxyamides. Protection using [(2-trimethylsilyl)-ethoxy]methyl chloride, methoxymethyl chloride, ter/-butylchlorodimeth-ylsilane, or zm-butylchlorodiphenylsilane followed by ozonolysis gave the protected N-(y- or <5-hydroxyacyl)indole derivatives. Mild saponification gave indole and the acetal- or silyl-protected hydroxy acids. 

The facility for 4-metalation shown by 3-substituted pyridines is continued with bipyridyl derivatives, and thus 3,3 -bis[2-(trimethyIsilyl)ethoxy]-methyl-2,2 -bipyridine gave the 4,4 -dilithio species on treatment with n-BuLi, and this then afforded 4,4 -disubstituted bipyridines, often in very good yield (Scheme 111)(88HCA957). 

Pyrrole, 1-acetic acid, 2-formyl-5-ethoxy-methyl) Lf 36 ... 

Aus l-[(2-Trimethylsilyl-ethoxy)-methyl]-imidazol konnen in Eintopfsynthesen durch sukzessive Metallierung und Umsetzung mit Elektrophilen 1,2,5-trisubstituierte Derivate wie z. B. 5-Formyl-2-phenylthio-1 -[2- (trimethylsilyl-ethoxy) -methyl]- (90%) oder 2-Phenylthio-1-[2-(trimethylsilyl-ethoxy)-methyl]-5-trimethylsiloxy-imidazol (79%) hergestellt werden1024. 

CII2-OC2II5 sc6n5 HjC-S-S-CHj SCHj 4-Brom-1-( ethoxy-methyl)-5-methylthio-2-phenyl-thio-... 63 57 1031... 

CH2 -OCjH5 SCH3 2-Ethoxy carbonyl-4-( ethoxy-methyl)-5-methyltkio-... 69 70... 

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