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Glycine incorporation 18

W9. Wyngaarden, J. B., Normal glycine incorporation into uric acid in primary gout. Metah., Clin. Exptl. 7, 374-375 (1958). [Pg.211]

The laboratory of Sidransky et al.52-53 62 in 1967-1968 demonstrated that L-tryptophan alone elicited a response of hepatic polyribosomes toward heavier aggregation as well as an enhancement of protein synthesis as measured in vivo or in vitro. The single administration of tryptophan alone, but not of one of three other essential amino acids (threonine, methionine, or isoleucine), elicited a stimulatory hepatic response that was similar to that obtained with a complete amino acid mixture.53 Earlier, Feigelson et al.63 in 1959 had reported that the parenteral administration of tryptophan in the rat produced a transient elevation in hepatic protein synthesis as determined by measuring 2[14C]glycine incorporation into hepatic protein. Subsequent studies from other laboratories60 64-69 confirmed the stimulatory effect of tryptophan on hepatic protein synthesis. [Pg.33]

The excessive endogenous oxalate formation appears to be due to a metabolic change in glycine metabolism. Thus, Scowen et al. (S8) found that the administration of labeled glycine to such patients is followed by a prompt and considerable incorporation of the isotope into the urinary oxalate. The excessive glycine incorporation into urinary oxalate was confirmed recently in a patient with primary hyperoxaluria by Elder and Wyngaarden (El), who found, on the contrary, a normal incorporation in another patient having only inconstant hyperoxaluria. [Pg.90]

Cycloadditions. Glycine incorporated into Oppolzer s sultam is transformed into the sulfamido ketene that reacts with imines to form p-lactams. ... [Pg.83]

Labeled glycine incorporated into collagen. Ti and NOE values of collagen in solution and reconstituted fibrils shows that rapid reorientation of helical backbone persists in fibrils. [Pg.393]

In humans, Necheles and Rai [142] observed that 5)S-androstane-3a-ol-17-one but not 5a-androstane-17 8-ol-3-one increased H-glycine incorporation into heme in adult bone marrow aspirates in vitro. [Pg.128]

These studies raise two problems (1) what is the primary lesion responsible for the chain of biochemical alterations and, (2) are the biochemical injuries responsible for the histological alterations observed after steroid administration Since the effect of steroid on respiration does not correlate with its effect on the glycine incorporation in proteins and nucleic acids, the primary effect of the steroid appears to be interference with the bioenergetic pathway, possibly by inhibiting the utilization of glucose by lymphocytes. [Pg.470]

Uric acid was isolated by anione exchange chromatography (Johnson and Emmerson, 1972) from freshly collected 12-h-urine samples for 6 days, and from 5 additional 2 -h-samples in the case of glycine incorporation. [Pg.318]

The glycine incorporation studies performed in two subjects support the hypothesis that purine biosynthesis is not inhibited by oral purine administration. Cumulative renal excretion of 15 N as uric acid over 11 days is shown in Figure 1 and 2. After correction of renal uric acid excretion for extrarenal excretion, in Subject 4 15 N excretion was 0.29 percent of the dose given orally during purine-free diet and 0.28 percent during purine supplementation. Corresponding values in Subject 5 were 0.22 and 0.26 percentjrespec-tively. [Pg.320]

Fig. 1. Sucrose density gradient profiles of the 5-30% PEG fraction in the presence of (o) and absence of ( ) 5.0 mM GMP in the gradient medium. Glycine incorporation into purines... Fig. 1. Sucrose density gradient profiles of the 5-30% PEG fraction in the presence of (o) and absence of ( ) 5.0 mM GMP in the gradient medium. Glycine incorporation into purines...
The techniques used to study glycine incorporation into human leucocytes were those described by Diamond et al (1), with minor modifications. [Pg.54]

It has long been established that glycine incorporation into uric acid, in vivo, is enhanced in certain patients with primary or idiopathic gout (7,8). Since increased glycine incorporation into uric acid precursors can also be demonstrated in vitro in the leucocytes of patients with primary gout, a readily accessible model may be available for the study of purine metabolism in these patients, and other groups as well. [Pg.60]

In this connection, it is interesting to note that in the early in vivo studies on glycine incorporation into uric acid (8), the two patients with azotemia due to chronic renal disease who were included in the investigation showed an enhanced incorporation of labelled glycine into their urinary uric acid. [Pg.60]

In patients with chronic renal failure, the bone marrow is generally hypercellular with a shift to the left - as in toxic conditions. The neutrophilic leucocytosis in the peripheral blood is accompanied by a shift to the right in the granulocytic series to include many segmented neutrophils (12). Whether this would account for the increased glycine incorporation into purines in leucocytes of patients with chronic renal failure is entirely speculative. [Pg.61]

The new reaction of formate mentioned above did not take place in all experiments. In several instances, the ratio of formate glycine incorporation approached 2 1, and the formate label was approximately equally distributed between C2 and 0. It was observed in these latter experiments that purine synthesis de novo (as measured by the incorporation of NH2CH2C"00H into C4) took place much more rapidly than in the experiments demonstrating unequal formate incorporation. It was believed that rapid synthesis de novo of the purine ring was masking the enzymatic exchange reaction of formate with inosinic acid. [Pg.242]

Applications. Amphoterics of this class are mainly used ih personal care products (e.g., coco amphocarboxy glycinate) incorporated in baby shampoos, they reduce the eye irritation. Other applications are as fabric softeners, industrial cleaners (due to their high electrolyte tolerance), and car cleaners. [Pg.29]

I4c] glycine incorporation into urinary uric acid... [Pg.309]


See other pages where Glycine incorporation 18 is mentioned: [Pg.99]    [Pg.265]    [Pg.78]    [Pg.393]    [Pg.582]    [Pg.6]    [Pg.64]    [Pg.35]    [Pg.221]    [Pg.276]    [Pg.384]    [Pg.122]    [Pg.423]    [Pg.424]    [Pg.20]    [Pg.28]    [Pg.53]    [Pg.73]    [Pg.73]    [Pg.74]    [Pg.75]    [Pg.217]    [Pg.213]    [Pg.64]    [Pg.64]    [Pg.384]    [Pg.20]    [Pg.170]    [Pg.367]    [Pg.246]    [Pg.289]    [Pg.289]   
See also in sourсe #XX -- [ Pg.342 ]




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