Glyceric phospho

The stmcture was determined to 2.8 A resolution in the laboratory of Tom Steitz, Yale University, (d) The glycolytic enzyme phospho-glycerate mutase, which catalyzes transfer of a phos-phoryl group from carbon 3 to carbon 2 In phosphoglycerate. The structure was determined to 2.S A resolution in the laboratory of Herman Watson, Bristol University, UK. (Adapted from J. Richardson.)... 

O -. - which is isomerized by transfer of the phosphoryl group to give 3-phospho-glycerate. 

O-Phosphonato-D-glyceroyl phosphate or 3-phospho-D-glyceroyl phosphate or 1,3-bisphospho-D-glycerate (for biochemical usage)... 

Glycolysis A net formation of two results from the formation of lactate from one molecule of glucose, generated in two reactions catalyzed by phospho-glycerate kinase and pyruvate kinase, respectively (Figure 17-2). 

All vertebrates can form certain amino acids from amphibolic intermediates or from other dietary amino acids. The intermediates and the amino acids to which they give rise are a-ketoglutarate (Gin, Gin, Pro, Hyp), oxaloacetate (Asp, Asn) and 3-phospho-glycerate (Ser, Gly). 

CATALYTIC ACTIVITY D-RIBULOSE 1,5-BISPHOSPHATE + CO(2) = 2 3-PHOSPHO-D-GLYCERATE. 

The Truhlar group has reported an interesting theoretical study of H/D kinetic isotope effects for conversion of 2 phospho-D-glycerate to phosophoenolpyruvate catalyzed by the yeast enolase enzyme. The proton transfer step (first reaction step in Fig. 11.10) is the rate limiting step and was chosen for theoretical study. The KIE for proton/deuteron transfer is kn/kD = 3.3 at 300 K. 

The isotope independent potential energy surface was evaluated using a mixed quantum mechanics/molecular mechanics (QM/MM) method. The system (N atoms) was partitioned into Nqm quantum mechanical atoms and Nmm classical mechanical atoms. Nqm consisted of the 15 atom substrate (phospho-D-glycerate)... 

Samson, L, Kerremans, L., Rozenski, J., Samyn, B., Van beeumen, J., and Herdewijn, P. Identification of a peptide inhibitor against glycosomal phospho-glycerate kinase of Trypanosoma bmcei by a synthetic peptide library... 

After donating its phosphate group to ADP, 1,3-diphosphoglycerate is converted into 3-phospho-glycerate. This reaction is followed by enzymic modification to 2-phosphoglycerate. 

Elimination of water from 2-phospho-glycerate produces the phosphate ester of the enol form of pyruvate—phosphoeno/pyruvate (PEP). This reaction also raises the second phosphate residue to a high potential. 

Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (nonphosphorylating) [EC 1.2.1.9], also referred to as triose-phosphate dehydrogenase, catalyzes the reaction of D-glyceraldehyde 3-phosphate with NADP+ and water to produce 3-phospho-D-glycerate and NADPH. 

This enzyme [EC 2.7.1.31] catalyzes the reaction of ATP with (R)-glycerate to produce ADP and 3-phospho-(R)-glycerate. 

This enzyme [EC 5.4.2.1] (also known as phosphoglycer-ate phosphomutase and phosphoglyceromutase) catalyzes the reaction of 2-phospho-D-glycerate with 2,3-di-phosphoglycerate to produce 3-phospho-D-glycerate and... 

Probably the most abundant naturally occurring catalyst, this enzyme [EC 4.1.1.39], also known as rubisco , catalyzes the reaction of D-ribulose 1,5-bisphosphate with carbon dioxide to produce two 3-phospho-D-glycerate. The enzyme can also use dioxygen as a substrate instead of carbon dioxide, producing 3-phospho-D-glycerate and 2-phosphoglycolate. 

Another enzyme with a function very similar to that of aconitase is enolase, which contains magnesium ion (48) and catalyzes the interconversion of phospho-glyceric acid and phosphoenolpyruvic acid. The magnesium can be replaced by... 

Harlos K, Vas M, Blake CF. Crystal structure of the binary complex of pig muscle phosphogycerate kinase and its substrate 3-phospho-D-glycerate. Proteins Struct Funct Genet 1992 12 133-144. 

Noble MEM, Verlinde CLMJ, Groendijk H, Kalk KH, Wierenga RK, Hoi WGJ. Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase a critical assessment of the predicted and observed structures of the complex with 2-phospho-glycerate. J Med Chem 1991 34 2709-2718. 

S 2 ,3 -dideoxy-2 ,3 -didehydro-/3-L-5-fluorodeoxycytidine -h 3-phospho-D-glycerate <7> (<7> 3.6fold higher activity compared to 2 -deoxycytidine... 

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