Critical Assessment

CASP stands for Critical Assessment of techniques for protein Structure Prediction. 

Mosimann S, S Meleshko and M N G Jones 1995. A Critical Assessment of Comparative Molecular Modeling of Tertiary Structures of Proteins. Proteins Structure, Function and Genetics 23 301-317. 

Moult J, T Hubbard, K Fldelis and J T Pedersen 1999. Critical Assessment of Methods of Protein Structure Prediction (CASP) Round III. Proteins Structure, Function and Genetics Suppl. 3 2-6. 

D. Sharp, bioprotein Manufacture A. Critical Assessment, Ellis Horwood, Chichester, U.K., 1989, p. 140. 

U.S. Environmental Protection Agency (EPA), The Acidic Deposition Phenomenon and Its Effect, vol. 2 Effects Sciences, Critical Assessment Review Papers, Report EPA 600/9-83-016AF, EPA, Washington, D.C., 1984, pp. 4—11. 

Performance. Consumer acceptance is a criterion on which cosmetic marketers caimot compromise. Whereas the likes and dislikes of consumers are in a state of constant flux, some product features are critical. A deodorant that does not deodorize or a hair coloring that fades in sunlight is unacceptable. Performance is tested by in vitro techniques during formulation, but the ultimate test of a product s performance requires in-use experience with consumers and critical assessment by trained observers. Performance tests can sometimes be combined with in-use safety tests, and protocols for such programs have been developed. 

S Mosimann, R Meleshko, MNG lames. A critical assessment of comparative molecular modeling of tertiary structures of proteins. Proteins 23 301-317, 1995. 

J Moult, T Flubbard, SFI Bryant, K Fidelis, JT Pedersen. Critical assessment of methods of protein structure prediction (CASP) Round II. Proteins Suppl 1 2-6, 1997. 

RL Dunbrack Jr, DL Gerloff, M Bower, X Chen, O Lichtarge, FE Cohen. Meeting review The second meeting on the critical assessment of techniques for protein structure prediction (CASP2), Asilomar, CA, Dec 13-16, 1996. Folding Des 2 R27-R42, 1997. 

Asthmagens. Critical assessments of the evidence for agents implicated m occupational asthma 1997. The technical basis for COSHH essentials. Easy steps to control chemicals... 

The strongest verification for a 3D-protein model comes from the experimental 3D-structure. This is the objective of the Critical Assessment of Techniques for Protein Structure Prediction, CASP ( http //predic tioncenter.org), where the structural models are made in advance of the experimental structure of a particular protein. 

Methods for measurement of kp have been reviewed by Stickler,340 41 van Herk Vl and more recently by Beuermann and Buback.343 A largely non critical summary of values of kp and k, obtained by various methods appears in the Polymer Handbook.344 Literature values of kp for a given monomer may span two or more orders of magnitude. The data and methods of measurement have heen critically assessed by IUPAC working parties"45"01 and reliable values for most common monomers are now available. 43 The wide variation in values of kp (and k,) obtained from various studies docs not reflect experimental error but differences in data interpretation and the dependence of kinetic parameters on chain length and polymerization conditions. 

Following on from the above, various methods have been described to test and/or rank the livingness of polymerization processes." Ul7 20 All of these tests have limitations.. The following list paraphrases a set of criteria for living polymerization set out by Quirk and Lee11 who also critically assessed their applicability primarily in the context of living anionic polymerization. 

Because thermal gradients vary considerably within boilers, a typical BW sample, which is essentially representative of average internal bulk water conditions, is unlikely to provide sufficient valid information necessary for the critical assessment of conditions at boiler surfaces. This makes fine-tune control of coordinated phosphate programs within the areas they are most needed very difficult, if not impossible, especially because caustic and saline concentrations may be much higher under deposits than in the bulk water as a result of localized effects. 

A critical assessment of the chemical thermodynamic properties of the actinides and their compounds is presently being prepared by an international team of scientists under the auspices of the International Atomic Energy Agency (Vienna). As a result of this effort, four publications (1, 2, 3, 5) have already become available and a further ten 6-T4), including the halides (8) and aqueous complexes with Tnorganic ligands (12),... 

Critical assessment of phase-diagram data employing the thermodynamics of the phase equilibria in the form of phase-diagram modeling provides consistent thermochemical data (including also the liquid solution) for binary metal-boron systems such as V—B Cr—B, Mn—B, Fe —B, Co—B, Ni—Mo—B and Nb—B, W—B, A1 — B Despite these efforts, reinvestigation of binary systems is... 

The vast quantity of metallurgical data on phase equilibria have been reviewed " - , including a handbook of phase diagrams . Structural data for inter-metallic phases and compounds have been critically assessed ". ... 

The Sr-Cu system has been critically assessed. The most recent phase diagram, determined by combining differential thermal analysis and x-ray diffraction techniques, contains two intermediate compounds, both of which form in peritectic reactions, SrCu (588°C) and SrCu, (845°C) SrCu has also been prepared for independent structural analysis-. ... 

Bennett WA (2005) Critical assessment of the Delta smelt population in the San Francisco Estuary, California. San Francisco Estuary Watershed Sci 3(2) Article 1. http //repositories. cdlib.org/jmie/sfews... 

ROsch N (1999) A Critical Assessment of Density Functional Theory with Regard to Applications in Organometallic Chemistry. 4 109-163... 

In most solvent-containing consumer products the solvent is lost to the environment on use. List three consumer products that contain non-aqueous solvents and assess the likely longer-term environmental impacts of continued use of these products. Critically assess more benign alternatives. 

Butters, M., Catterick, D., Craig, A. et al. (2006) Critical Assessment of Pharmaceutical Processes - A Rationale for Changing the Synthetic Route. Chemical Reviews, 106(7), 3002-3027. 

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