Alpha glucosidase

Hydrolysis of terminal non-reducing 1,4-Unked alpha-D-glucose residues of alpha glucose (e.g. maltose to glucose) Alpha-glucosidase Alpha-D-glucoside glucohydrolase 3.2.1.20... 

FUJITA H, YAMAGAMi T (2001) Fermented soybean-derived Touchi-extract with anti-diabetic effect via alpha-glucosidase inhibitory action in a long-term administration study with KKAy mice. Life Sci. 70 219-27. 

FUJITA H, YAMAGAMI T, OHSHIMA K (2001a) Long-teim ingestion of a fermented soybean-derived Touchi-extract with alpha-glucosidase inhibitory activity is safe and effective in humans with borderline and mild type-2 diabetes. JNutr. 131 2105-8. 

FUJITA H, YAMAGAMI T, OHSHIMA K (2001b) Fermented soybean-derived water-soluble Touch extract inhibits alpha-glucosidase and is antiglycemic in rats and humans after single oral treatments. /lyMr ". 131 1211-3. 

Acarbose, an antidiabetic that inhibits intestinal alpha glucosidases, may cause flatulence and diarrhoea. The tablets, v/hich can be taken three times daily, must be taken before food. 

Holman RR. (1998) Assessing the potential for alpha-glucosidase inhibitors in prediabetic states. Diabetes Res Clin Pract 40 21-25. 

Kawabata J, Mizuhata K, Sato E, Nishioka T, Aoyama Y, Kasai T. (2003) 6-hydroxyflavonoids as alpha-glucosidase inhibitors from marjoram (Origanum majorana) leaves. Biosci Biotechnol Biochem 67 445-447. 

Insulin Exenatide is not a substitute for insulin in insulin-requiring patients. Do not use exenatide in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. The concurrent use of exenatide with insulin, thiazolidinediones, D-phenylalanine derivatives, meglitinides, or alpha-glucosidase inhibitors has not been studied. 

By competitively inhibiting the alpha-glucosidase enzymes in the mucosa cells of the small intestine these agents suppress the breakdown of di-, oligo-and polysaccharides into monosaccharides and thus decrease carbohydrate absorption. In this way postprandial elevations of blood glucose levels can be prevented or diminished. 

Voglibose is considered to be an improvement over the other two alpha-glucosidase inhibitors both in terms of potenty and side effect profile. 

Kishnani PS, Corzo D, Nicolino M, Byrne B, Mandel H, Hwu WL et al. Recombinant human acid [alpha]-glucosidase major clinical benefits in infantile-onset Pompe disease. Neurology 2007 68(2) 99-109. 

II.f.2.1. Oral hypoglycaemic agents. There are now five groups of orally active drugs available to lower blood glucose in clinical practice (Table 2). These are sulphonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones, and the incretin derivatives. 

Alpha glucosidase inhibitors mainly reduced postprandial blood glucose and has a mean lowering of initial HbAlc of 0.5-1.0%. The major side effects are abdominal discomfort. Hence it is advised to begin with a low dose (25-50 mg) at the start of meals and increase slowly up to a dose of 100 mg three times daily, as judged by the patient s response. 

Gowri, P. M, Tiwaii, A. K, Ali, A. Z, Rao, J. M. Inhibition of alpha-glucosidase and amylase by bartogenic add isolated from Barringtonia racemosa Roxb. seeds. Phytothe-raphy Research. (2007). 

It acts by competitively inhibiting pancreatic alphaamylase and intestinal alpha glucosidase hydrolase enzymes. 

Dignum M, Kerler J, Verpoorte R (2001b) Alpha-glucosidase and peroxidase stability in crude enzyme extracts from green beans of Vanilla planifilolia Andrews. Phytochem Anal 12 174-179... 

Alpha-Glucosidase Inhibitor Chemical Structure Oral Dose... 

Alpha-glucosidase inhibitors are infrequently prescribed in the United States because of their prominent gastrointestinal adverse effects and relatively minor glucose-lowering benefit. 

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