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A-Glucosidase inhibitory activity

A novel 13-membered ring thiocyclitol (214), isolated from Salacia reticulata Wight (family Hippocrateaceae), showed promising a-glucosidase inhibitory activity (IC50 maltase, 0.227 /tM sucrase, 0.186 //M isomaltase, 0.099 however, it did not inhibit a-amylase from porcine pan-... [Pg.579]

Atta-ur-Rahman, S. Zareen, M. I. Choudary, M. N. Akhtar, and S. N. Khan, a-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus, J. Nat. Prod., 71 (2008) 910-913. [Pg.282]

H. Ouadid-Ahidouch, and J. M. Garcia Fernandez, Synthesis of N-, S-, and C-glycoside castanosper-mine analogues with selective neutral a-glucosidase inhibitory activity as antitumour agents, Chem. Commun., 46 (2010) 5328-5330. [Pg.296]

Muraoka, O, Ying, S, Yoshikai, K, Matsuura, Y, Yamada, E, Minematsu, T, Tanabe, G, Matsuda, H, Yoshikawa, M, Synthesis of a nitrogen analogue of salacinol and its a-glucosidase inhibitory activity, Chem. Pharm. Bull, 49, 1503-1505, 2001. [Pg.430]

Valiolamine (89), an aminocyclitol produced by Streptomyces hygroscopicus var. limoneus, is a potent inhibitor of pig intestinal maltase and sucrase, with IC50 values of 2.2 and 0.049 pM, respectively [107]. Numerous iV-substituted valiolamine derivatives were synthesized to enhance its a-glucosidase inhibitory activity in vitro and the very simple derivative voglibose (90), which is obtained by reductive amination of valiolamine with dihydroxyacetone, was selected as the potential oral antidiabetic agent [108]. Its IC50 values toward maltase and sucrase were 0.015 and 0.0046 pM, respectively. Voglibose (the brand name Basen) has been commercially available for the treatment of type 2 diabetes in Japan since 1994. [Pg.1902]

These a-glucosidase inhibitory activities of 2, 2,5-trimethoxy-6,7-methylenedioxyisoflavanone (12) and tlatlancuayin (2 ,5-dimethoxy-6,7-methylenedioxyisoflavone, 11) were lower when compared to that (a-glucosidase inhibitory activities) of hyperoside (quercetin-3-O-galactoside, hyperin, 13) [34, 35],... [Pg.222]

A strong correlation was found between total water soluble phenolic content of the yogurt extracts with the a-glucosidase inhibitory activity (Apostolidis et al. 2006), indicating that addition of fruit with significant phytochemical content can increase the a-glucosidase inhibitory... [Pg.110]

Reviews have appeared on carba-amino sugars and their a-glucosidase inhibitory activity, and on the chemistry and enzymic preparation of complex chiral and bio-active azamono- and oligo-saccharides and their derivatives. ... [Pg.228]

M. I. Choudhary, 1. Batool, S. N. Khan, N. Sultana, S. A. A. Shah, A. Ur-Rahman, Microbial transformation of oleanolic acid by Fusarium Uni and a-glucosidase inhibitory activity of its transformed products, Nat. Prod. Res. 2008. 22,489-494. [Pg.712]

See other pages where A-Glucosidase inhibitory activity is mentioned: [Pg.551]    [Pg.552]    [Pg.558]    [Pg.564]    [Pg.569]    [Pg.579]    [Pg.282]    [Pg.127]    [Pg.1920]    [Pg.1979]    [Pg.1981]    [Pg.83]    [Pg.164]    [Pg.591]    [Pg.592]    [Pg.917]    [Pg.1937]    [Pg.107]    [Pg.109]    [Pg.109]    [Pg.109]    [Pg.110]    [Pg.111]    [Pg.113]    [Pg.253]   
See also in sourсe #XX -- [ Pg.592 ]

See also in sourсe #XX -- [ Pg.314 ]



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A-glucosidases

Glucosidase

Glucosidases

Inhibitory activity

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