Acid alpha-glucosidase deficiency

Pauly, D. F., Johns, D. C., Matelis, L. A., Lawrence, J. H., Byrne, B. J. and Kessler, P. D. (1998). Complete correction of acid alpha-glucosidase deficiency in Pompe disease fibroblasts in vitro, and lysosomally targeted expression in neonatal rat cardiac and skeletal muscle. Gene Ther. 5, 473-480. 

Raben, N., Plotz, P. and Byrne, B. J. (2002). Acid alpha-glucosidase deficiency (glycogenosis type II, Pompe disease). Curr. Mol. Med. 2, 145-166. 

Bijvoet, A. G., Kroos, M. A., Pieper, F. R., Van, d., V, De Boer, H. A., Van der Ploeg, A. T., Verbeet, M. P. and Reuser, A. J. (1998). Recombinant human acid alpha-glucosidase High level production in mouse milk, biochemical characteristics, correction of enzyme deficiency in GSDII KO mice. Hum. Mol. Genet. 7, 1815-1824. 

Pauly, D. F., Fraites, T. J., Toma, C., Bayes, H. S., Huie, M. L., Hirschhorn, R., Plotz, P. H., Raben, N., Kessler, P. D. and Byrne, B. J. (2001). Intercellular transfer of the virally derived precursor form of acid alpha-glucosidase corrects the enzyme deficiency in inherited cardioskeletal myopathy Pompe disease. Hum. Gene Ther. 12(5), 527-538. 

Zaretsky, J. Z., Candotti, F., Boerkoel, C., Adams, E. M., Yewdell, J. W., Blaese, R. M. and Plotz, P. H. (1997). Retroviral transfer of acid alpha-glucosidase cDNA to enzyme-deficient myoblasts results in phenotypic spread of the genotypic correction by both secretion and fusion. Hum. Gene Ther. 8, 1555-1563. 

Note Pompe disease is an autosomal recessive muscular disorder caused by the deficiency or lack of the enzyme acid alpha-glucosidase, which is essential for normal muscle development and function. The... 

Bijvoet AG, Kroos MA, Pieper FR, et al. Recombinant human acid alpha-glucosidase high level production in mouse milk, biochemical characteristics, correction of enzyme deficiency in GSDII KO mice. Hum. Mol. Genet., 1998 7(11) 1815-1824. 

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