Transporters intestinal

ERLWANGER K H, UNMACK M A, GRONDAHL M L, PIERZYNOWSKI S G, AALBAEK B, DANTZER V, SKADHAUGE E (1999) Effects of dietary substitution with raw and heat-treated cowpea (Vigna unguiculata) on intestinal transport and pancreatic enzymes in the pig. Zentralbl Veterinarmed A. 46 581-92. 

NORDRUM S, BAKKE-MCKELLEP A M, KROGDAHL A, BUDDINGTON R K (2000) Effects of Soybean meal and salinity on intestinal transport of nutrients in Atlantic salmon (Salmo salar L.) and rainbow trout Oncorhynchus mykiss). Comp Biochem Physiol B Biochem Mol Biol. 125 317-35. 

M Asgharnejad. Investigation into intestinal transport and absorption of an amino acid, amino acid analougue and its peptideomimetic prodrug. PhD dissertation, Chapter IV. pp 109-127, The University of Michigan, 1992. 

D Burston, DM Matthews. (1972). Intestinal transport of dipeptides containing acidic and basic L-amino acids and a neutral D-amino acid. Clin Sci Mol Med 42 4P. 

M (blockage of calcium intestinal transport response to vitamin D)... 

Luo, F., P. Paranjpe, A. Guo, E. Rubin, and P. Sinko. Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1., Drug Metab. Dispos. 2002, 30, 763-770... 

Yu, H., Cook, T. J., Sinko, P. J., Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages, Pharm. Res. 1997, 34, 757-762. 

Tsuji, A., Tamai, I., Carrier-mediated intestinal transport of drugs, Pharm. Res. 1996, 33, 963-977. 

Fig. 7.1. The intestinal permeability of drugs in vivo is the total transport parameter that may be affected by several parallel transport mechanisms in both absorptive and secretory directions. Some of the most important transport proteins that may be involved in the intestinal transport of drugs and their metabolites across intestinal epithelial membrane barriers in humans are displayed.

Investigations of regional differences in permeability and metabolism have been carried out using a variety of animal models [22, 29, 75, 102, 109, 112, 137]. Animal tissues (mainly from rats) are widely used in the Ussing chamber to investigate intestinal transport of drugs, and regional aspects [29, 75, 138], whereas few studies have been conducted with human tissues due to their limited availability. 

The transporter-mediated uptake of drugs into epithelial cells is emerging as a new trend in biopharmaceutics [6]. Utilization of the intestinal epithelial transporters to facilitate the absorption of drugs or prodrugs appears to be an attractive delivery approach. The purpose of this chapter is to describe the pharmaceutical and medicinal relevances of intestinal transporters. This will provide new knowledge for strategies to enhance intestinal absorption of drugs. 

Bretschneider, B., M. Brandsch, and R. Neubert. Intestinal transport of beta-lactam antibiotics analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm. Res. 1999, 16, 55-61. 

Tamai, I., et al. Partidpation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochem. Biophys. Res. Commun. 1995, 214, 482-489. 

This chapter describes some of the modified mammalian cell-based systems that have been developed to express intestinal cytochrome P450 enzymes and intestinal transporters. The reader should be aware that other experimental systems, such as transporter expression and drug uptake studies in Xenopus laevis oocytes, have also shown considerable promise [1],... 

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