Glipizide

Chemical Name 1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl] phenyl] sulfonyl] urea [Pg.730]

T rade Name Manufacturer Country Year Introduced [Pg.730]

5-Methyl pyrazine-2-carboxylic acid is refluxed with thionyl chloride in anhydrous benzene for approximately 12 hours. Benzene and thionyl chloride excess is removed by distillation. Then some anhydrous dioxane is added and this acid chloride solution is allowed to drop into p-((3-aminoethyl)-benzenesulfonamide suspension in dioxane and anhydrous pyridine. The resulting mixture is then refluxed for 3 hours. Dioxane is removed by distillation and then the residue is washed with water and acetic acid. The raw acylated sulfonamide is then filtered and crystallized from 95% ethanol, thus obtaining a product of MP 200 to 203 C. [Pg.730]

This product Is then reacted with cyclohexyl Isocyanate to give glipizide. [Pg.730]

AmbrogI, V. and Logemann, W. U.S. Patent 3669,966 June 13,1972 assigned to Carlo Erba SpA, Italy [Pg.730]

5-Methylpyrazine-2-carboxylic acid p-(/3-Aminoethy )benzenesulf onamide [Pg.730]

Cyclohexyl isocyanate A cetoh examide Glipizide Gliquidone... [Pg.1625]

Mindiab - Glipizide Minias - Lormetazepam Minibetic - Glipizide Minigest - Megestrol acetate Minihep - Heparin... [Pg.1718]

Sulphonylureas Chlorpropamide, glibenclamideb, gliclazide, glimepiride, glipizide, gliquidone, tolazamide, tolbutamide Stimulate insulin secretion (typically 6-24 h) Oral... [Pg.117]

SLTR1/Kir6.2 Glibenclamide and glipizide that block pancreatic KAXP channels have been used for the treatment of type II diabetes. New class of insulin secretagogues includes repaglinide and nateglinide, which improve insulin secretion, action and reduce carbohydrate absorption. [Pg.996]

C7H11NO 3/73-53-3) see Acetohexamide Glibenclamide Glipizide Gliquidone Lomustine Talinolol cyclohexylmagnesiiun bromide... [Pg.2340]

CjjHjjOj 35363-65-6) see Dimethisterone methyl pyrazine-2-carboxylate (QH N202 6164-79-0) see Pyrazinamide 5-methyl-2-pyrazinecarboxylic acid (QHfiN202 5521-55-1) see Adpimox Glipizide 5-methylpyrazine-2-carboxylic acid see under 5-methyl-2-pyrazinecarboxylic acid... [Pg.2422]

Albuterol/ipratropium inhaler 2 puffs every 6 hours Glipizide 10 mg once daily Hydrochlorothiazide 25 mg once daily Lisinopril 20 mg once daily... [Pg.1190]

This system is the only osmotic system developed commercially at this time that is suitable for the oral administration of insoluble drugs to humans. It has been utilized in the development of several other drugs including isradipine, doxazosin, diltiazem, contraceptive steroids, glipizide, and verapamil [48-53], The system has also been utilized to codeliver the free bases of compounds normally administered as water-soluble salts such as pseudoephedrine and bromo-pheniramine [54], The latter system includes both a loading dose and a controlled release dose and is intended for applications in the over-the-counter market. [Pg.448]

RW Korsmeyer, KD Wilner, WE Ballinger, FC Falkner. Asymmetric membrane tablets for delivery of glipizide. Proceedings of the International Symposium on the Controlled Release of Bioactive Materials, Stockholm, 1997, pp 239-240. [Pg.455]

AL Kuczynski, AD Ayer, PSL Wong. Oral hypoglycemic glipizide granulation. US Patent 5,024,843, 1991. [Pg.456]

NA 20 mg of glipizide, 2,000 mg of metformin Combination medication Used as initial therapy 2.5/250 mg twice a day... [Pg.230]

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