Sulphonylureas glipizide

ANION EXCHANGE RESINS SULPHONYLUREAS- GLIPIZIDE Glipizide absorption may be 1 by colestyramine Colestyramine interrupts the enterohepatic circulation of glipizide Avoid co-administration... 

Sulphonylureas Chlorpropamide, glibenclamideb, gliclazide, glimepiride, glipizide, gliquidone, tolazamide, tolbutamide Stimulate insulin secretion (typically 6-24 h) Oral... 

CICLOSPORIN SULPHONYLUREAS- GUPIZIDE May T plasma concentrations of ciclosporin Glipizide inhibits CYP3A4-mediated metabolism of ciclosporin Monitor plasma ciclosporin levels to prevent toxicity... 

At least for some sulphonylureas (gliclazide and glipizide), intra- and inter-individual variations in absorption are pronounced, perhaps explaining the large variations observed in their responses (Hartling et al., 1987). 

The sulphonylureas, particularly chlorpropamide, may infrequently induce a syndrome of inappropriate secretion of antidiuretic hormone (augmenting hypothalamic-pituitary release of this hormone) characterized by water retention, hyponatraemia, low serum osmolality and high urine osmolality, and central nervous system signs. Water retention and dilutional hyponatraemia have occurred after administration of chlorpropamide and tolbutamide to NIDDM patients, especially those with congestive heart failure or hepatic cirrhosis. Glipizide, acetohexamide (Moses et al., 1973), tolazamide, glibenclamide are mildly diuretic. 

A report suggests that the hypocholesterolaemic effect of colestipol is unaffected in insulin-treated diabetics but it may be ineffective in those taking phenformin and sulphonylureas. Diabetic control was not affected. Colestyramine may enhance the effect of acarbose, and insulin levels may rebound if both drugs are stopped at the same time. There is evidence that the absorption of glipizide may be reduced by about 30% if it is taken at the same time as colestyramine, but tolbutamide does not appear to be affected. 

Sulphonylureas A study in six type 2 diabetics found that a single 20-mg dose of nifedipine had no effect on the pharmacokinetics of glipizide 5 to 30 mg daily. Similarly, nimodipine caused no change in the pharmacokinetics of ibenciamide in 11 patients. ... 

On the whole cimetidine and ranitidine do not appear to significantly alter diabetic control with sulphonylureas, although cases of adverse effects have been seen when glibenclamide was given with ranitidine, and when gliclazide or glipizide were given with cimetidine. 

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